| Reactions and Genes | L-Tryptophan (N) |
|---|
| remove |
| L-quinate + a quinone→3-dehydroquinate + a quinol (EC 1.1.5.8) |
| No genes |
Mandelate racemase (in reverse):
(R)-4-hydroxymandelate→(S)-4-hydroxymandelate (EC 5.1.2.2) |
| RR42_RS23065 | -0.0 |
Mandelate racemase (in reverse):
(R)-mandelate→(S)-mandelate (EC 5.1.2.2) |
| RR42_RS23065 | -0.0 |
Tryptophan 2,3-dioxygenase:
L-tryptophan + dioxygen→N-formyl-L-kynurenine (EC 1.13.11.11; 1.13.11.52) |
| RR42_RS15390 | -3.5 |
| shikimate + a quinone→3-dehydroshikimate + a quinol (EC 1.1.5.8) |
| No genes |
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10) |
| RR42_RS06175 | N.D. |
| RR42_RS17690 | -0.2 |
| RR42_RS32450 | +0.0 |
| RR42_RS33730 | +0.1 |
| (S)-4-hydroxymandelate + an electron-transfer quinone→4-hydroxyphenylglyoxylate + an electron-transfer quinol |
| No genes |
Arylformamidase:
N-formyl-L-kynurenine + H2O→L-kynurenine + formate + H+ (EC 3.5.1.9) |
| RR42_RS15380 | -2.6 |
| RR42_RS33590 | +0.1 |
(S)-mandelate dehydrogenase:
(S)-mandelate + an oxidized electron carrier→phenylglyoxylate + a reduced two electron carrier (EC 1.1.99.31) |
| No genes |
Benzoylformate decarboxylase:
phenylglyoxylate + H+→benzaldehyde + CO2 (EC 4.1.1.7) |
| RR42_RS32970 | +0.0 |
| 3-dehydroshikimate→protocatechuate + H2O (EC 4.2.1.118) |
| No genes |
Benzoylformate decarboxylase:
4-hydroxyphenylglyoxylate + H+→4-hydroxybenzaldehyde + CO2 (EC 4.1.1.7) |
| RR42_RS32970 | +0.0 |
Kynureninase:
L-kynurenine + H2O→anthranilate + L-alanine + H+ (EC 3.7.1.3) |
| RR42_RS15385 | -4.9 |
Anthranilate 1,2-dioxygenase (deaminating, decarboxylating):
anthranilate + NAD(P)H + dioxygen + 3 H+→catechol + ammonium + CO2 + NAD(P)+ (EC 1.14.12.1) |
| No genes |
Benzaldehyde dehydrogenase (NAD(+)):
benzaldehyde + NAD+ + H2O→benzoate + NADH + 2 H+ (EC 1.2.1.28) |
| No genes |
Benzaldehyde dehydrogenase (NADP(+)):
benzaldehyde + NADP+ + H2O→benzoate + NADPH + 2 H+ (EC 1.2.1.7) |
| No genes |
4-hydroxybenzaldehyde dehydrogenase:
4-hydroxybenzaldehyde + NAD+ + H2O→4-hydroxybenzoate + NADH + 2 H+ (EC 1.2.1.64) |
| No genes |
| 4-hydroxybenzaldehyde + NADP+ + H2O→4-hydroxybenzoate + NADPH + 2 H+ (EC 1.2.1.96) |
| No genes |
4-hydroxybenzoate 3-monooxygenase:
4-hydroxybenzoate + NADPH + dioxygen + H+→protocatechuate + NADP+ + H2O (EC 1.14.13.2) |
| RR42_RS21940 | -0.0 |
Benzoate 1,2-dioxygenase:
benzoate + NADH + dioxygen + H+→3,5-cyclohexadiene-1,2-diol-1-carboxylate + NAD+ (EC 1.14.12.10) |
| RR42_RS23490 | -0.1 |
| RR42_RS23495 | +0.1 |
| RR42_RS23500 | +0.1 |
1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase:
3,5-cyclohexadiene-1,2-diol-1-carboxylate + NAD+→catechol + CO2 + NADH (EC 1.3.1.25) |
| RR42_RS23485 | -0.1 |
Protocatechuate 3,4-dioxygenase:
protocatechuate + dioxygen→3-carboxy-cis,cis-muconate + 2 H+ (EC 1.13.11.3) |
| RR42_RS32060 | -0.2 |
| RR42_RS32065 | +0.2 |
3-carboxy-cis,cis-muconate cycloisomerase (in reverse):
3-carboxy-cis,cis-muconate + H+→(2-carboxy-2,5-dihydro-5-oxofuran-2-yl)-acetate (EC 5.5.1.2) |
| RR42_RS25850 | +0.3 |
| RR42_RS32055 | -0.4 |
Catechol 1,2-dioxygenase:
catechol + dioxygen→cis,cis-muconate + 2 H+ (EC 1.13.11.1) |
| RR42_RS23505 | -0.0 |
| RR42_RS32875 | -0.1 |
| RR42_RS32880 | -0.1 |
Catechol 2,3-dioxygenase:
catechol + dioxygen→(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H+ (EC 1.13.11.2) |
| RR42_RS32655 | +0.5 |
| RR42_RS34600 | +0.1 |
2-hydroxymuconate-semialdehyde hydrolase:
(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O→(2Z)-2-hydroxypenta-2,4-dienoate + formate + H+ (EC 3.7.1.9) |
| RR42_RS25595 | +0.0 |
| RR42_RS34060 | -0.1 |
4-carboxymuconolactone decarboxylase:
(2-carboxy-2,5-dihydro-5-oxofuran-2-yl)-acetate + H+→(4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2 (EC 4.1.1.44) |
| RR42_RS02890 | -0.0 |
| RR42_RS23415 | +0.3 |
| RR42_RS32050 | -0.0 |
| RR42_RS35470 | +0.1 |
Muconate cycloisomerase (in reverse):
cis,cis-muconate + H+→(+)-muconolactone (EC 5.5.1.1) |
| RR42_RS21835 | -0.1 |
2-oxopent-4-enoate hydratase (in reverse):
(2Z)-2-hydroxypenta-2,4-dienoate + H2O→(S)-4-hydroxy-2-oxopentanoate (EC 4.2.1.80) |
| RR42_RS05105 | N.D. |
| RR42_RS27885 | -0.3 |
| RR42_RS32645 | +0.6 |
| RR42_RS34355 | -0.1 |
Muconolactone Delta-isomerase:
(+)-muconolactone→(4,5-dihydro-5-oxofuran-2-yl)-acetate (EC 5.3.3.4) |
| RR42_RS10025 | -0.0 |
| RR42_RS10695 | -0.1 |
| RR42_RS21840 | -0.5 |
| RR42_RS33065 | -0.0 |
3-oxoadipate enol-lactonase:
(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O→3-oxoadipate + H+ (EC 3.1.1.24) |
| RR42_RS00755 | +0.0 |
| RR42_RS10565 | +0.7 |
| RR42_RS10690 | +0.1 |
| RR42_RS21850 | +0.5 |
| RR42_RS24710 | N.D. |
| RR42_RS30700 | +0.0 |
| RR42_RS32050 | -0.0 |
4-hydroxy-2-oxovalerate aldolase:
(S)-4-hydroxy-2-oxopentanoate→acetaldehyde + pyruvate (EC 4.1.3.39) |
| RR42_RS05095 | -0.1 |
| RR42_RS27900 | -0.0 |
| RR42_RS31860 | -0.0 |
| RR42_RS32625 | +0.2 |
3-oxoadipate CoA-transferase:
3-oxoadipate + succinyl-CoA→3-oxoadipoyl-CoA + succinate (EC 2.8.3.6) |
| RR42_RS10005 | -0.2 |
| RR42_RS10010 | -0.1 |
| RR42_RS22965 | +0.0 |
| RR42_RS22970 | +0.1 |
| RR42_RS31950 | +0.3 |
| RR42_RS31955 | +0.0 |
| RR42_RS35920 | -0.1 |
| RR42_RS35925 | +0.0 |
Acetaldehyde dehydrogenase (acetylating):
acetaldehyde + coenzyme A + NAD+→acetyl-CoA + NADH + H+ (EC 1.2.1.10) |
| RR42_RS05100 | -0.1 |
| RR42_RS27895 | -0.0 |
| RR42_RS31855 | +0.1 |
| RR42_RS32630 | -0.1 |
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→acetyl-CoA + succinyl-CoA (EC 2.3.1.174) |
| RR42_RS35915 | -0.5 |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information