MetaCyc Pathway: valproate β-oxidation in Cupriavidus basilensis FW507-4G11

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Reactions and Genes L-Valine (N)
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Butyrate--CoA ligase:
valproate + ATP + coenzyme A→valproyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
valproyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-2-propylpent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
Enoyl-CoA hydratase (in reverse):
(2E)-2-propylpent-2-enoyl-CoA + H2O→(3S)-3-hydroxy-2-propylpentanoyl-CoA (EC 4.2.1.17)
RR42_RS00730 -0.0
RR42_RS02510 +0.1
RR42_RS02525 +0.1
RR42_RS03015 +0.2
RR42_RS04550 +0.1
RR42_RS05755 +0.3
RR42_RS05760 +0.1
RR42_RS07510 +0.2
RR42_RS10250 -0.4
RR42_RS10265 +0.2
RR42_RS10270 -0.7
RR42_RS11095 -0.1
RR42_RS12500 +0.0
RR42_RS12795 +0.1
RR42_RS13545 N.D.
RR42_RS16175 +0.4
RR42_RS16790 +0.2
RR42_RS18250 -0.1
RR42_RS18255 -0.4
RR42_RS19805 -0.6
RR42_RS19815 N.D.
RR42_RS22630 -0.1
RR42_RS22680 +0.2
RR42_RS23295 +0.1
RR42_RS23450 +0.1
RR42_RS23710 -0.4
RR42_RS24355 -0.1
RR42_RS24895 -0.4
RR42_RS25480 -0.2
RR42_RS25525 -0.1
RR42_RS25900 +0.0
RR42_RS28050 N.D.
RR42_RS28325 +0.1
RR42_RS28330 -0.5
RR42_RS28425 +0.5
RR42_RS28545 -2.0
RR42_RS28550 -0.8
RR42_RS29425 +0.6
RR42_RS29465 +0.0
RR42_RS29940 -0.1
RR42_RS29945 -0.3
RR42_RS31580 +0.1
RR42_RS31675 -0.5
RR42_RS31935 +0.3
RR42_RS31945 -0.1
RR42_RS34175 +0.4
RR42_RS34180 -0.1
RR42_RS34905 -0.8
RR42_RS35130 -0.3
RR42_RS35270 -0.1
RR42_RS36335 +0.1
RR42_RS36495 +0.2
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxy-2-propylpentanoyl-CoA + NAD+→3-oxo-2-propylpentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
RR42_RS02510 +0.1
RR42_RS03005 +0.2
RR42_RS03440 -0.4
RR42_RS05760 +0.1
RR42_RS10265 +0.2
RR42_RS11095 -0.1
RR42_RS22630 -0.1
RR42_RS25375 +0.1
RR42_RS28325 +0.1
RR42_RS29465 +0.0
RR42_RS31050 +0.2
RR42_RS35270 -0.1
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-2-propylpentanoyl-CoA + coenzyme A→pentanoyl-CoA + propanoyl-CoA (EC 2.3.1.16)
RR42_RS00885 -0.2
RR42_RS02515 N.D.
RR42_RS03010 -0.2
RR42_RS07610 -0.1
RR42_RS07645 N.D.
RR42_RS10260 -0.1
RR42_RS10540 +0.2
RR42_RS11085 -0.3
RR42_RS16595 +0.1
RR42_RS22625 -0.3
RR42_RS24300 +0.0
RR42_RS24970 +0.2
RR42_RS25210 +0.2
RR42_RS25380 -0.2
RR42_RS25455 -0.5
RR42_RS26090 +0.0
RR42_RS27160 -0.4
RR42_RS28055 +0.1
RR42_RS31890 -0.1
RR42_RS31920 -0.2
RR42_RS35915 +0.1
RR42_RS36320 -0.5
RR42_RS37020 -0.2
pentanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-pent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.1)
RR42_RS00895 -0.1
RR42_RS04580 -0.0
RR42_RS11075 +0.1
RR42_RS25105 -0.4
RR42_RS28565 -0.9
RR42_RS36390 +0.0
(2E)-pent-2-enoyl-CoA + H2O→(3S)-3-hydroxypentanoyl-CoA
No genes
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxypentanoyl-CoA + NAD+→3-oxopentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
RR42_RS02510 +0.1
RR42_RS03005 +0.2
RR42_RS03440 -0.4
RR42_RS05760 +0.1
RR42_RS10265 +0.2
RR42_RS11095 -0.1
RR42_RS22630 -0.1
RR42_RS25375 +0.1
RR42_RS28325 +0.1
RR42_RS29465 +0.0
RR42_RS31050 +0.2
RR42_RS35270 -0.1
Acetyl-CoA C-acyltransferase (in reverse):
3-oxopentanoyl-CoA + coenzyme A→propanoyl-CoA + acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
RR42_RS00885 -0.2
RR42_RS02515 N.D.
RR42_RS03010 -0.2
RR42_RS07610 -0.1
RR42_RS07645 N.D.
RR42_RS10260 -0.1
RR42_RS10540 +0.2
RR42_RS11085 -0.3
RR42_RS16595 +0.1
RR42_RS22625 -0.3
RR42_RS24300 +0.0
RR42_RS24970 +0.2
RR42_RS25210 +0.2
RR42_RS25380 -0.2
RR42_RS25455 -0.5
RR42_RS26090 +0.0
RR42_RS27160 -0.4
RR42_RS27235 -0.3
RR42_RS28055 +0.1
RR42_RS28390 -0.3
RR42_RS31890 -0.1
RR42_RS31920 -0.2
RR42_RS35915 +0.1
RR42_RS36320 -0.5
RR42_RS37020 -0.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information