MetaCyc Pathway: benzoate biosynthesis III (CoA-dependent, non-β-oxidative) in Cupriavidus basilensis FW507-4G11

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Reactions and Genes L-Valine (N)
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Phenylalanine ammonia-lyase:
L-phenylalanine→trans-cinnamate + ammonium (EC 4.3.1.24; 4.3.1.25; 5.4.3.10)
No genes
trans-cinnamate + ATP + coenzyme A→(E)-cinnamoyl-CoA + AMP + diphosphate
No genes
Enoyl-CoA hydratase (in reverse):
(E)-cinnamoyl-CoA + H2O→(S)-3-hydroxy-3-phenylpropanoyl-CoA (EC 4.2.1.17)
RR42_RS00730 -0.0
RR42_RS02510 +0.1
RR42_RS02525 +0.1
RR42_RS03015 +0.2
RR42_RS04550 +0.1
RR42_RS05755 +0.3
RR42_RS05760 +0.1
RR42_RS07510 +0.2
RR42_RS10250 -0.4
RR42_RS10265 +0.2
RR42_RS10270 -0.7
RR42_RS11095 -0.1
RR42_RS12500 +0.0
RR42_RS12795 +0.1
RR42_RS13545 N.D.
RR42_RS16175 +0.4
RR42_RS16790 +0.2
RR42_RS18250 -0.1
RR42_RS18255 -0.4
RR42_RS19805 -0.6
RR42_RS19815 N.D.
RR42_RS22630 -0.1
RR42_RS22680 +0.2
RR42_RS23295 +0.1
RR42_RS23450 +0.1
RR42_RS23710 -0.4
RR42_RS24355 -0.1
RR42_RS24895 -0.4
RR42_RS25480 -0.2
RR42_RS25525 -0.1
RR42_RS25900 +0.0
RR42_RS28050 N.D.
RR42_RS28325 +0.1
RR42_RS28330 -0.5
RR42_RS28425 +0.5
RR42_RS28545 -2.0
RR42_RS28550 -0.8
RR42_RS29425 +0.6
RR42_RS29465 +0.0
RR42_RS29940 -0.1
RR42_RS29945 -0.3
RR42_RS31580 +0.1
RR42_RS31675 -0.5
RR42_RS31935 +0.3
RR42_RS31945 -0.1
RR42_RS34175 +0.4
RR42_RS34180 -0.1
RR42_RS34905 -0.8
RR42_RS35130 -0.3
RR42_RS35270 -0.1
RR42_RS36335 +0.1
RR42_RS36495 +0.2
(S)-3-hydroxy-3-phenylpropanoyl-CoA→benzaldehyde + acetyl-CoA
No genes
Benzaldehyde dehydrogenase (NAD(+)):
benzaldehyde + NAD+ + H2O→benzoate + NADH + 2 H+ (EC 1.2.1.28)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information