MetaCyc Pathway: superpathway of phenylethylamine degradation in Cupriavidus basilensis FW507-4G11

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Reactions and Genes L-Valine (N)
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Primary-amine oxidase:
2-phenylethylamine + dioxygen + H2O→phenylacetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.21; 1.4.3.4)
RR42_RS24620 +0.3
RR42_RS24630 -0.1
RR42_RS24640 -0.1
Phenylacetaldehyde dehydrogenase:
phenylacetaldehyde + NAD+ + H2O→phenylacetate + NADH + 2 H+ (EC 1.2.1.39)
RR42_RS32140 -0.0
Phenylacetate--CoA ligase:
phenylacetate + ATP + coenzyme A→phenylacetyl-CoA + AMP + diphosphate (EC 6.2.1.30)
RR42_RS01655 +0.0
RR42_RS18265 +0.0
RR42_RS23755 +0.1
phenylacetyl-CoA + NADPH + dioxygen + H+→2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP+ + H2O (EC 1.14.13.149)
RR42_RS23725 -0.1
RR42_RS23730 -0.8
RR42_RS23735 -0.2
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA→2-oxepin-2(3H)-ylideneacetyl-CoA (EC 5.3.3.18)
RR42_RS18255 -0.4
2-oxepin-2(3H)-ylideneacetyl-CoA + H2O→3-oxo-5,6-didehydrosuberyl-CoA semialdehyde (EC 3.3.2.12)
RR42_RS05755 +0.3
3-oxo-5,6-didehydrosuberyl-CoA semialdehyde + NADP+ + H2O→3-oxo-5,6-didehydrosuberyl-CoA + NADPH + 2 H+ (EC 1.2.1.91)
No genes
3-oxo-5,6-didehydrosuberyl-CoA + coenzyme A→(2E)-5-carboxy-2-pentenoyl-CoA + acetyl-CoA (EC 2.3.1.223)
No genes
Enoyl-CoA hydratase (in reverse):
(2E)-5-carboxy-2-pentenoyl-CoA + H2O→(3S)-hydroxyadipyl-CoA (EC 4.2.1.17)
RR42_RS00730 -0.0
RR42_RS02510 +0.1
RR42_RS02525 +0.1
RR42_RS03015 +0.2
RR42_RS04550 +0.1
RR42_RS05755 +0.3
RR42_RS05760 +0.1
RR42_RS07510 +0.2
RR42_RS10250 -0.4
RR42_RS10265 +0.2
RR42_RS10270 -0.7
RR42_RS11095 -0.1
RR42_RS12500 +0.0
RR42_RS12795 +0.1
RR42_RS13545 N.D.
RR42_RS16175 +0.4
RR42_RS16790 +0.2
RR42_RS18250 -0.1
RR42_RS18255 -0.4
RR42_RS19805 -0.6
RR42_RS19815 N.D.
RR42_RS22630 -0.1
RR42_RS22680 +0.2
RR42_RS23295 +0.1
RR42_RS23450 +0.1
RR42_RS23710 -0.4
RR42_RS24355 -0.1
RR42_RS24895 -0.4
RR42_RS25480 -0.2
RR42_RS25525 -0.1
RR42_RS25900 +0.0
RR42_RS28050 N.D.
RR42_RS28325 +0.1
RR42_RS28330 -0.5
RR42_RS28425 +0.5
RR42_RS28545 -2.0
RR42_RS28550 -0.8
RR42_RS29425 +0.6
RR42_RS29465 +0.0
RR42_RS29940 -0.1
RR42_RS29945 -0.3
RR42_RS31580 +0.1
RR42_RS31675 -0.5
RR42_RS31935 +0.3
RR42_RS31945 -0.1
RR42_RS34175 +0.4
RR42_RS34180 -0.1
RR42_RS34905 -0.8
RR42_RS35130 -0.3
RR42_RS35270 -0.1
RR42_RS36335 +0.1
RR42_RS36495 +0.2
3-hydroxyacyl-CoA dehydrogenase:
(3S)-hydroxyadipyl-CoA + NAD+→3-oxoadipoyl-CoA + NADH + H+ (EC 1.1.1.35)
RR42_RS02510 +0.1
RR42_RS03005 +0.2
RR42_RS03440 -0.4
RR42_RS05760 +0.1
RR42_RS10265 +0.2
RR42_RS11095 -0.1
RR42_RS22630 -0.1
RR42_RS25375 +0.1
RR42_RS28325 +0.1
RR42_RS29465 +0.0
RR42_RS31050 +0.2
RR42_RS35270 -0.1
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→succinyl-CoA + acetyl-CoA (EC 2.3.1.174)
RR42_RS35915 +0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information