MetaCyc Pathway: TCA cycle VI (Helicobacter) in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Reactions and Genes L-Leucine (C)
remove
2-oxoglutarate synthase:
2-oxoglutarate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→succinyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.3)
No genes
3-oxoacid CoA-transferase:
succinyl-CoA + acetoacetate→succinate + acetoacetyl-CoA (EC 2.8.3.5)
RR42_RS06555 -2.3
RR42_RS06560 N.D.
Succinate dehydrogenase (ubiquinone) (in reverse):
succinate[in] + a menaquinone→fumarate[in] + a menaquinol (EC 1.3.5.1)
No genes
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate (EC 4.2.1.2)
RR42_RS02195 +0.1
RR42_RS13905 -0.2
RR42_RS27740 -0.1
RR42_RS33090 -0.1
RR42_RS37365 -0.0
(S)-malate + a menaquinone→oxaloacetate + a menaquinol (EC 1.1.5.4)
No genes
Citrate (Si)-synthase:
oxaloacetate + acetyl-CoA + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
RR42_RS09325 -0.0
RR42_RS10505 -0.3
RR42_RS14430 N.D.
RR42_RS32385 -0.1
RR42_RS36245 +0.2
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3)
RR42_RS11270 +0.5
RR42_RS14490 +0.3
RR42_RS23515 +0.1
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
RR42_RS11270 +0.5
RR42_RS14490 +0.3
RR42_RS23515 +0.1
Isocitrate dehydrogenase (NADP(+)):
D-threo-isocitrate + NADP+→2-oxoglutarate + CO2 + NADPH (EC 1.1.1.42)
RR42_RS17135 +0.2
RR42_RS22955 +0.2
RR42_RS28800 +1.3
RR42_RS29535 -0.1

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information