MetaCyc Pathway: noradrenaline and adrenaline degradation in Cupriavidus basilensis FW507-4G11

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Reactions and Genes Ethanol (C)
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Catechol O-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→L-normetanephrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Monoamine oxidase:
(R)-noradrenaline + dioxygen + H2O→3,4-dihydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
RR42_RS24620 +0.1
RR42_RS24630 -0.1
RR42_RS24640 +0.3
Phenylethanolamine N-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→(R)-adrenaline + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.28)
No genes
Monoamine oxidase:
(R)-adrenaline + dioxygen + H2O→3,4-dihydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)
RR42_RS24620 +0.1
RR42_RS24630 -0.1
RR42_RS24640 +0.3
Catechol O-methyltransferase:
(R)-adrenaline + S-adenosyl-L-methionine→metanephrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Monoamine oxidase:
L-normetanephrine + dioxygen + H2O→3-methoxy-4-hydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
RR42_RS24620 +0.1
RR42_RS24630 -0.1
RR42_RS24640 +0.3
Alcohol dehydrogenase (in reverse):
3,4-dihydroxyphenylglycolaldehyde + NADH + H+→(R)-3,4-dihydroxyphenylglycol + NAD+ (EC 1.1.1.1)
RR42_RS09745 -0.4
RR42_RS10210 -0.1
RR42_RS10545 +0.1
RR42_RS11005 +0.1
RR42_RS18350 -0.2
RR42_RS24070 +0.1
RR42_RS24560 -0.3
RR42_RS25355 -0.0
RR42_RS25775 N.D.
RR42_RS28650 N.D.
RR42_RS32920 +0.0
RR42_RS34260 -1.7
RR42_RS34620 +0.0
RR42_RS36940 -0.4
Aldehyde dehydrogenase (NAD(+)):
3,4-dihydroxyphenylglycolaldehyde + NAD+ + H2O→3,4-dihydroxymandelate + NADH + 2 H+ (EC 1.2.1.3)
RR42_RS01275 -0.1
RR42_RS04280 -0.3
RR42_RS11360 +0.0
RR42_RS13660 +0.3
RR42_RS18500 +0.0
RR42_RS21485 -0.2
RR42_RS23750 -0.1
RR42_RS24065 -0.2
RR42_RS24390 +0.1
RR42_RS24705 +0.2
RR42_RS24840 +0.2
RR42_RS25005 -0.1
RR42_RS25010 -0.1
RR42_RS26255 -0.1
RR42_RS27350 -0.1
RR42_RS27780 -0.3
RR42_RS29955 -0.1
RR42_RS32140 -0.1
RR42_RS34255 -5.3
Monoamine oxidase:
metanephrine + dioxygen + H2O→3-methoxy-4-hydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)
RR42_RS24620 +0.1
RR42_RS24630 -0.1
RR42_RS24640 +0.3
Catechol O-methyltransferase:
(R)-3,4-dihydroxyphenylglycol + S-adenosyl-L-methionine→3-methoxy-4-hydroxyphenylglycol + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Catechol O-methyltransferase:
3,4-dihydroxymandelate + S-adenosyl-L-methionine→vanillylmandelate + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Alcohol dehydrogenase:
3-methoxy-4-hydroxyphenylglycol + NAD+→3-methoxy-4-hydroxyphenylglycolaldehyde + NADH + H+ (EC 1.1.1.1)
RR42_RS09745 -0.4
RR42_RS10210 -0.1
RR42_RS10545 +0.1
RR42_RS11005 +0.1
RR42_RS18350 -0.2
RR42_RS24070 +0.1
RR42_RS24560 -0.3
RR42_RS25355 -0.0
RR42_RS25775 N.D.
RR42_RS28650 N.D.
RR42_RS32920 +0.0
RR42_RS34260 -1.7
RR42_RS34620 +0.0
RR42_RS36940 -0.4
Aldehyde dehydrogenase (NAD(+)):
3-methoxy-4-hydroxyphenylglycolaldehyde + NAD+ + H2O→vanillylmandelate + NADH + 2 H+ (EC 1.2.1.3)
RR42_RS01275 -0.1
RR42_RS04280 -0.3
RR42_RS11360 +0.0
RR42_RS13660 +0.3
RR42_RS18500 +0.0
RR42_RS21485 -0.2
RR42_RS23750 -0.1
RR42_RS24065 -0.2
RR42_RS24390 +0.1
RR42_RS24705 +0.2
RR42_RS24840 +0.2
RR42_RS25005 -0.1
RR42_RS25010 -0.1
RR42_RS26255 -0.1
RR42_RS27350 -0.1
RR42_RS27780 -0.3
RR42_RS29955 -0.1
RR42_RS32140 -0.1
RR42_RS34255 -5.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information