MetaCyc Pathway: 8-amino-7-oxononanoate biosynthesis I in Cupriavidus basilensis FW507-4G11

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Reactions and Genes propionate (C)
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a malonyl-[acp] + S-adenosyl-L-methionine→a malonyl-[acp] methyl ester + S-adenosyl-L-homocysteine (EC 2.1.1.197)
No genes
Beta-ketoacyl-acyl-carrier-protein synthase II:
a malonyl-[acp] + a malonyl-[acp] methyl ester + H+→a 3-oxoglutaryl-[acp] methyl ester + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
RR42_RS14090 N.D.
RR42_RS31185 +0.0
RR42_RS31200 -0.1
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxoglutaryl-[acp] methyl ester + NADPH + H+→a (3R)-3-hydroxyglutaryl-[acp] methyl ester + NADP+ (EC 1.1.1.100)
RR42_RS04765 -0.6
RR42_RS08710 -0.1
RR42_RS09330 -0.0
RR42_RS10255 +0.1
RR42_RS10315 +0.3
RR42_RS10320 +0.2
RR42_RS11070 +0.1
RR42_RS11550 -0.2
RR42_RS13675 +0.0
RR42_RS13690 +0.2
RR42_RS14100 N.D.
RR42_RS16365 +0.2
RR42_RS16375 -0.2
RR42_RS16800 +0.1
RR42_RS17660 +0.1
RR42_RS21765 -0.0
RR42_RS21790 +0.5
RR42_RS21865 +0.0
RR42_RS22390 -0.1
RR42_RS22710 -0.2
RR42_RS22740 +0.0
RR42_RS22810 -0.5
RR42_RS23420 -0.8
RR42_RS23690 +0.8
RR42_RS24195 +0.1
RR42_RS25125 -0.1
RR42_RS25495 +0.0
RR42_RS28045 -0.1
RR42_RS28985 -0.0
RR42_RS29305 -0.1
RR42_RS31190 -0.1
RR42_RS31670 +0.1
RR42_RS31820 -0.1
RR42_RS31835 +0.0
RR42_RS31900 +0.3
RR42_RS33070 -0.2
RR42_RS33710 -0.2
RR42_RS34680 -1.3
RR42_RS35910 +0.0
RR42_RS36415 -0.2
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyglutaryl-[acp] methyl ester→a (2E)-enoylglutaryl-[acp] methyl ester + H2O (EC 4.2.1.59)
RR42_RS11820 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-enoylglutaryl-[acp] methyl ester + NADH + H+→a glutaryl-[acp] methyl ester + NAD+ (EC 1.3.1.9)
RR42_RS03815 -0.1
RR42_RS10070 -0.0
RR42_RS10225 -0.1
RR42_RS13390 +0.2
RR42_RS25240 +0.0
RR42_RS31520 -0.2
RR42_RS31940 -0.2
RR42_RS36330 -0.4
Beta-ketoacyl-acyl-carrier-protein synthase II:
a glutaryl-[acp] methyl ester + a malonyl-[acp] + H+→a 3-oxopimeloyl-[acp] methyl ester + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
RR42_RS14090 N.D.
RR42_RS31185 +0.0
RR42_RS31200 -0.1
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxopimeloyl-[acp] methyl ester + NADPH + H+→a (3R)-3-hydroxypimeloyl-[acp] methyl ester + NADP+ (EC 1.1.1.100)
RR42_RS04765 -0.6
RR42_RS08710 -0.1
RR42_RS09330 -0.0
RR42_RS10255 +0.1
RR42_RS10315 +0.3
RR42_RS10320 +0.2
RR42_RS11070 +0.1
RR42_RS11550 -0.2
RR42_RS13675 +0.0
RR42_RS13690 +0.2
RR42_RS14100 N.D.
RR42_RS16365 +0.2
RR42_RS16375 -0.2
RR42_RS16800 +0.1
RR42_RS17660 +0.1
RR42_RS21765 -0.0
RR42_RS21790 +0.5
RR42_RS21865 +0.0
RR42_RS22390 -0.1
RR42_RS22710 -0.2
RR42_RS22740 +0.0
RR42_RS22810 -0.5
RR42_RS23420 -0.8
RR42_RS23690 +0.8
RR42_RS24195 +0.1
RR42_RS25125 -0.1
RR42_RS25495 +0.0
RR42_RS28045 -0.1
RR42_RS28985 -0.0
RR42_RS29305 -0.1
RR42_RS31190 -0.1
RR42_RS31670 +0.1
RR42_RS31820 -0.1
RR42_RS31835 +0.0
RR42_RS31900 +0.3
RR42_RS33070 -0.2
RR42_RS33710 -0.2
RR42_RS34680 -1.3
RR42_RS35910 +0.0
RR42_RS36415 -0.2
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxypimeloyl-[acp] methyl ester→a (2E)-enoylpimeloyl-[acp] methyl ester + H2O (EC 4.2.1.59)
RR42_RS11820 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-enoylpimeloyl-[acp] methyl ester + NADH + H+→a pimeloyl-[acp] methyl ester + NAD+ (EC 1.3.1.9)
RR42_RS03815 -0.1
RR42_RS10070 -0.0
RR42_RS10225 -0.1
RR42_RS13390 +0.2
RR42_RS25240 +0.0
RR42_RS31520 -0.2
RR42_RS31940 -0.2
RR42_RS36330 -0.4
a pimeloyl-[acp] methyl ester + H2O→a pimeloyl-[acp] + methanol + H+ (EC 3.1.1.85)
No genes
8-amino-7-oxononanoate synthase:
a pimeloyl-[acp] + L-alanine + H+→(8S)-8-amino-7-oxononanoate + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.47)
RR42_RS00930 -1.4
RR42_RS10140 -1.2
RR42_RS29265 +0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information