MetaCyc Pathway: L-lysine biosynthesis II in Cupriavidus basilensis FW507-4G11

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Reactions and Genes D-Fructose (C)
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Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP
(EC 2.7.2.4)
RR42_RS06370 N.D.
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate
(EC 1.2.1.11)
RR42_RS14380 N.D.
L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (EC 4.3.3.7)
RR42_RS04230 -0.2
RR42_RS05135 -0.3
RR42_RS06250 -0.7
RR42_RS17475 +0.2
RR42_RS33075 +0.2
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+→(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ + H2O (EC 1.17.1.8)
RR42_RS17550 N.D.
RR42_RS18515 +0.2
Tetrahydrodipicolinate N-acetyltransferase:
(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O→L-2-acetamido-6-oxoheptanedioate + coenzyme A
(EC 2.3.1.89)
No genes
L-2-acetamido-6-oxoheptanedioate + L-glutamateN-acetyl-L,L-2,6-diaminopimelate + 2-oxoglutarate
No genes
N-acetyldiaminopimelate deacetylase:
N-acetyl-L,L-2,6-diaminopimelate + H2O→L,L-diaminopimelate + acetate
(EC 3.5.1.47)
RR42_RS07830 -0.1
RR42_RS30375 +0.2
Diaminopimelate epimerase:
L,L-diaminopimelate→meso-diaminopimelate
(EC 5.1.1.7)
RR42_RS01250 N.D.
RR42_RS03375 -3.1
RR42_RS37405 -0.0
Diaminopimelate decarboxylase:
meso-diaminopimelate + H+→L-lysine + CO2
(EC 4.1.1.20)
RR42_RS19050 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information