MetaCyc Pathway: L-phenylalanine degradation IV (mammalian, via side chain) in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Reactions and Genes L-Phenylalanine (C)
remove
Aromatic-L-amino-acid decarboxylase:
L-phenylalanine + H+→2-phenylethylamine + CO2 (EC 4.1.1.28; 4.1.1.53)
RR42_RS26695 -0.0
Aspartate transaminase:
L-phenylalanine + 2-oxoglutarate→3-phenyl-2-oxopropanoate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57)
RR42_RS01570 +0.3
RR42_RS01590 -0.1
RR42_RS02275 -0.1
RR42_RS04465 -0.1
RR42_RS04985 +0.1
RR42_RS05770 -0.1
RR42_RS05990 +0.0
RR42_RS09190 +0.0
RR42_RS09965 +0.0
RR42_RS10785 +0.1
RR42_RS12545 -0.8
RR42_RS14560 -0.1
RR42_RS15580 -0.0
RR42_RS16470 -0.0
RR42_RS18910 N.D.
RR42_RS21340 -0.1
RR42_RS25980 -0.0
RR42_RS26005 +0.0
RR42_RS26015 +0.0
RR42_RS26185 -0.1
RR42_RS26625 +0.1
RR42_RS28185 +0.1
RR42_RS32165 +0.1
RR42_RS33140 -0.0
RR42_RS33490 -2.0
RR42_RS33805 +0.1
RR42_RS35305 -0.0
RR42_RS36780 -0.1
4-hydroxyphenylpyruvate dioxygenase:
3-phenyl-2-oxopropanoate + dioxygen→(2-hydroxyphenyl)acetate + CO2 (EC 1.13.11.27)
RR42_RS32440 -0.2
RR42_RS32485 -0.1
RR42_RS33500 -2.9
Indolelactate dehydrogenase (in reverse):
3-phenyl-2-oxopropanoate + NADH + H+→(R)-3-(phenyl)lactate + NAD+ (EC 1.1.1.110)
No genes
Primary-amine oxidase:
2-phenylethylamine + dioxygen + H2O→phenylacetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.21; 1.4.3.4)
RR42_RS24620 -0.1
RR42_RS24630 +0.1
RR42_RS24640 -0.2
Phenylacetaldehyde dehydrogenase:
phenylacetaldehyde + NAD+ + H2O→phenylacetate + NADH + 2 H+ (EC 1.2.1.39)
RR42_RS32140 +0.3
Phenylacetate--CoA ligase:
phenylacetate + ATP + coenzyme A→phenylacetyl-CoA + AMP + diphosphate (EC 6.2.1.30)
RR42_RS01655 +0.1
RR42_RS18265 +0.2
RR42_RS23755 -0.1
Glutamine N-phenylacetyltransferase:
phenylacetyl-CoA + L-glutamine→α-N-phenylacetyl-L-glutamine + coenzyme A + H+ (EC 2.3.1.14)
No genes
phenylacetyl-CoA + glycine→phenylacetylglycine + coenzyme A + H+ (EC 2.3.1.192)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information