MetaCyc Pathway: superpathway of L-methionine biosynthesis (transsulfuration) in Cupriavidus basilensis FW507-4G11

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Reactions and Genes L-Histidine (C)
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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
RR42_RS01570 +0.2
RR42_RS01590 -0.1
RR42_RS02275 -0.0
RR42_RS04985 -0.2
RR42_RS05770 -0.1
RR42_RS09190 +0.3
RR42_RS09965 +0.2
RR42_RS10785 -0.2
RR42_RS12545 -0.5
RR42_RS14560 -0.0
RR42_RS15580 +0.2
RR42_RS16470 +0.0
RR42_RS21340 -0.1
RR42_RS25980 -0.1
RR42_RS26005 +0.1
RR42_RS26015 -0.4
RR42_RS26185 +0.1
RR42_RS26625 +0.1
RR42_RS28185 -0.0
RR42_RS32165 +0.1
RR42_RS33140 +0.2
RR42_RS33805 +0.0
RR42_RS35305 -0.2
RR42_RS36780 -0.1
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
RR42_RS06370 N.D.
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
RR42_RS14380 N.D.
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
RR42_RS12540 N.D.
Homoserine O-succinyltransferase:
L-homoserine + succinyl-CoA→O-succinyl-L-homoserine + coenzyme A (EC 2.3.1.46)
No genes
Cystathionine gamma-synthase:
O-succinyl-L-homoserine + L-cysteine→L-cystathionine + H+ + succinate (EC 2.5.1.48)
RR42_RS06465 -0.1
RR42_RS14320 -4.2
RR42_RS32610 -0.1
Cysteine-S-conjugate beta-lyase:
L-cystathionine + H2O→L-homocysteine + ammonium + pyruvate (EC 4.4.1.13)
No genes
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase:
L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate→L-methionine + tetrahydropteroyl tri-L-glutamate (EC 2.1.1.14)
RR42_RS30660 -3.8
Methionine synthase:
L-homocysteine + a 5-methyltetrahydrofolate→L-methionine + a tetrahydrofolate (EC 2.1.1.13)
RR42_RS00770 -0.9
RR42_RS00775 -1.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information