MetaCyc Pathway: ureide biosynthesis in Cupriavidus basilensis FW507-4G11

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Reactions and Genes R2A with Doxycycline hyclate 0.0001 mg/ml
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IMP dehydrogenase:
IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205)
RR42_RS00320 +0.1
RR42_RS06470 +1.4
RR42_RS11750 N.D.
5'-nucleotidase:
XMP + H2O→xanthosine + phosphate (EC 3.1.3.5)
RR42_RS01130 -0.6
RR42_RS13200 -0.0
RR42_RS32020 +0.3
RR42_RS32200 N.D.
RR42_RS34235 -0.3
Purine-nucleoside phosphorylase:
xanthosine + phosphate→xanthine + α-D-ribose-1-phosphate (EC 2.4.2.1)
No genes
Xanthine dehydrogenase:
xanthine + NAD+ + H2O→urate + NADH + H+ (EC 1.17.1.4)
RR42_RS05335 -0.2
RR42_RS05340 +0.2
RR42_RS13620 -1.0
RR42_RS13625 -0.1
RR42_RS13630 +0.2
Urate oxidase:
urate + dioxygen + H2O→(S)-5-hydroxyisourate + hydrogen peroxide (EC 1.7.3.3)
RR42_RS05255 +0.7
RR42_RS16400 +0.1
RR42_RS32355 +0.2
Hydroxyisourate hydrolase:
(S)-5-hydroxyisourate + H2O→(S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + H+ (EC 3.5.2.17)
RR42_RS05270 +0.0
(S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + H+→(S)-(+)-allantoin + CO2 (EC 4.1.1.97)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information