MetaCyc Pathway: L-methionine salvage cycle I (bacteria and plants) in Cupriavidus basilensis FW507-4G11

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Reactions and Genes R2A with Doxycycline hyclate 0.0001 mg/ml
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S-methyl-5-thioribose kinase:
5-(methylsulfanyl)-D-ribose + ATP→S-methyl-5-thio-α-D-ribose 1-phosphate + ADP + H+ (EC 2.7.1.100)
No genes
S-methyl-5-thioribose-1-phosphate isomerase:
S-methyl-5-thio-α-D-ribose 1-phosphate→S-methyl-5-thio-D-ribulose 1-phosphate (EC 5.3.1.23)
No genes
Methylthioribulose 1-phosphate dehydratase:
S-methyl-5-thio-D-ribulose 1-phosphate→5-(methylsulfanyl)-2,3-dioxopentyl 1-phosphate + H2O (EC 4.2.1.109)
No genes
Acireductone synthase:
5-(methylsulfanyl)-2,3-dioxopentyl 1-phosphate→2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl 1-phosphate + H+ (EC 3.1.3.77; 5.3.2.5)
No genes
Acireductone synthase:
2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl 1-phosphate + H2O→1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate (EC 3.1.3.77; 3.1.3.87)
No genes
Acireductone dioxygenase (Fe(2+)-requiring):
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + dioxygen→4-(methylsulfanyl)-2-oxobutanoate + formate + H+ (EC 1.13.11.54)
No genes
4-(methylsulfanyl)-2-oxobutanoate + L-glutamine→2-oxoglutaramate + L-methionine (EC 2.6.1.117)
No genes
2-oxoglutaramate + H2O→2-oxoglutarate + ammonium (EC 3.5.1.111; 3.5.1.3)
No genes
Methionine adenosyltransferase:
L-methionine + ATP + H2O→S-adenosyl-L-methionine + diphosphate + phosphate (EC 2.5.1.6)
RR42_RS01265 N.D.
RR42_RS01270 -2.3
RR42_RS35330 +0.0
Adenosylmethionine decarboxylase:
S-adenosyl-L-methionine + H+→S-adenosyl 3-(methylsulfanyl)propylamine + CO2 (EC 4.1.1.50)
RR42_RS19905 -0.0
Spermidine synthase:
S-adenosyl 3-(methylsulfanyl)propylamine + putrescine→spermidine + S-methyl-5'-thioadenosine + H+ (EC 2.5.1.16)
RR42_RS14510 +0.0
RR42_RS17580 -0.2
RR42_RS19925 +0.2
RR42_RS33480 -0.5
Methylthioadenosine nucleosidase:
S-methyl-5'-thioadenosine + H2O→5-(methylsulfanyl)-D-ribose + adenine (EC 3.2.2.16; 3.2.2.9)
RR42_RS18455 +0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information