MetaCyc Pathway: guanosine ribonucleotides de novo biosynthesis in Cupriavidus basilensis FW507-4G11

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Reactions and Genes R2A with Doxycycline hyclate 0.0001 mg/ml
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IMP dehydrogenase:
IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205)
RR42_RS00320 +0.1
RR42_RS06470 +1.4
RR42_RS11750 N.D.
GMP synthase (glutamine-hydrolyzing):
XMP + ATP + L-glutamine + H2O→GMP + AMP + L-glutamate + diphosphate + 2 H+ (EC 6.3.5.2)
RR42_RS11740 N.D.
Guanylate kinase:
GMP + ATP→GDP + ADP (EC 2.7.4.8)
RR42_RS04905 N.D.
RR42_RS04910 N.D.
RR42_RS28065 -0.5
Nucleoside-diphosphate kinase:
GDP + ATP→GTP + ADP (EC 2.7.4.6)
RR42_RS03445 N.D.
RR42_RS13160 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information