MetaCyc Pathway: L-isoleucine biosynthesis V in Methanococcus maripaludis S2

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Reactions and Genes Formate no stress control
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Acetate--CoA ligase:
2-methylbutanoate + ATP + coenzyme A→(2S)-2-methylbutanoyl-CoA + AMP + diphosphate (EC 6.2.1.1)
MMP_RS00845 -0.1
MMP_RS06550 +0.2
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) (in reverse):
(2S)-2-methylbutanoyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→(3S)-3-methyl-2-oxopentanoate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.2.7.7)
MMP_RS06535 -1.6
MMP_RS06540 -1.4
MMP_RS06545 -1.6
Branched-chain-amino-acid transaminase (in reverse):
(3S)-3-methyl-2-oxopentanoate + L-glutamate→L-isoleucine + 2-oxoglutarate (EC 2.6.1.42)
MMP_RS00760 +0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information