MetaCyc Pathway: superpathway of methanogenesis in Methanococcus maripaludis S2

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Reactions and Genes McCas_H2_complete Bacitracin 0.003125 mM
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Acetate kinase:
acetate + ATP→acetyl phosphate + ADP (EC 2.7.2.1; 2.7.2.15)
No genes
CO2 + a methanofuran + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→a formylmethanofuran + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O (EC 1.2.7.12)
MMP_RS02695 -1.1
MMP_RS02700 -1.6
MMP_RS02710 -0.1
MMP_RS06415 N.D.
MMP_RS06420 N.D.
MMP_RS06425 N.D.
MMP_RS08715 -2.0
Methanol--5-hydroxybenzimidazolylcobamide Co-methyltransferase:
methanol + a [Co(I) methanol-specific corrinoid protein] + H+→a [methyl-Co(III) methanol-specific corrinoid protein] + H2O (EC 2.1.1.90)
No genes
methylamine + a [Co(I) methylamine-specific corrinoid protein] + H+→a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonium (EC 2.1.1.248)
No genes
dimethylamine + a [Co(I) dimethylamine-specific corrinoid protein] + H+→a [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine (EC 2.1.1.249)
No genes
trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein] + H+→a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine (EC 2.1.1.250)
No genes
Formylmethanofuran--tetrahydromethanopterin N-formyltransferase:
a formylmethanofuran + H+ + tetrahydromethanopterin→5-formyl-tetrahydromethanopterin + a methanofuran (EC 2.3.1.101)
MMP_RS08270 N.D.
Phosphate acetyltransferase (in reverse):
acetyl phosphate + coenzyme A→acetyl-CoA + phosphate (EC 2.3.1.8)
No genes
a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M→methyl-CoM + a [Co(I) methanol-specific corrinoid protein] + H+ (EC 2.1.1.246)
No genes
coenzyme M + a [methyl-Co(III) methylamine-specific corrinoid protein]→methyl-CoM + a [Co(I) methylamine-specific corrinoid protein] + H+ (EC 2.1.1.247)
No genes
coenzyme M + a [methyl-Co(III) dimethylamine-specific corrinoid protein]→methyl-CoM + a [Co(I) dimethylamine-specific corrinoid protein] + H+ (EC 2.1.1.247)
No genes
coenzyme M + a [methyl-Co(III) trimethylamine-specific corrinoid protein]→methyl-CoM + a [Co(I) trimethylamine-specific corrinoid protein] + H+ (EC 2.1.1.247)
No genes
Methenyltetrahydromethanopterin cyclohydrolase (in reverse):
5-formyl-tetrahydromethanopterin + H+→5,10-methenyltetrahydromethanopterin + H2O (EC 3.5.4.27)
MMP_RS06135 N.D.
CO-methylating acetyl-CoA synthase:
acetyl-CoA + a [Co(I) corrinoid Fe-S protein] + H+→carbon monoxide + a [methyl-Co(III) corrinoid Fe-S protein] + coenzyme A (EC 2.3.1.169; 2.3.3.M4; 2.3.3.M5)
MMP_RS05090 -0.1
Carbon-monoxide dehydrogenase (ferredoxin):
carbon monoxide + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O→CO2 + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.4; 2.3.3.M4; 2.3.3.M5)
MMP_RS05100 +0.1
5,10-methenyltetrahydromethanopterin hydrogenase:
5,10-methenyltetrahydromethanopterin + H2→5,10-methylene-tetrahydromethanopterin + H+ (EC 1.12.98.2)
MMP_RS00735 -0.3
a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrosarcinapterin→5-methyl-tetrahydrosarcinapterin + a [Co(I) corrinoid Fe-S protein] + H+ (EC 2.1.1.245; 2.3.3.M4)
MMP_RS05075 +0.0
5,10-methylene-tetrahydromethanopterin + a reduced factor 420→5-methyltetrahydromethanopterin + an oxidized factor 420 (EC 1.5.98.2)
MMP_RS00340 N.D.
Tetrahydromethanopterin S-methyltransferase:
5-methyl-tetrahydrosarcinapterin[in] + coenzyme M[in] + 2 Na+[in]→methyl-CoM[in] + tetrahydrosarcinapterin[in] + 2 Na+[out] (EC 2.1.1.86)
MMP_RS08030 N.D.
MMP_RS08035 N.D.
MMP_RS08040 N.D.
MMP_RS08045 N.D.
MMP_RS08050 N.D.
MMP_RS08055 N.D.
MMP_RS08060 N.D.
MMP_RS08065 N.D.
Tetrahydromethanopterin S-methyltransferase:
coenzyme M[in] + 5-methyltetrahydromethanopterin[in] + 2 Na+[in]→methyl-CoM[in] + 2 Na+[out] + tetrahydromethanopterin[in] (EC 2.1.1.86)
MMP_RS08030 N.D.
MMP_RS08035 N.D.
MMP_RS08040 N.D.
MMP_RS08045 N.D.
MMP_RS08050 N.D.
MMP_RS08055 N.D.
MMP_RS08060 N.D.
MMP_RS08065 N.D.
Coenzyme-B sulfoethylthiotransferase:
methyl-CoM + coenzyme B→methane + CoB-CoM heterodisulfide (EC 2.8.4.1)
MMP_RS08005 N.D.
MMP_RS08020 N.D.
MMP_RS08025 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information