MetaCyc Pathway: dopamine degradation in Cupriavidus basilensis FW507-4G11

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Reactions and Genes Carbon source Phenylacetic 2.5 mM
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Monoamine oxidase:
dopamine + dioxygen + H2O→3,4-dihydroxyphenylacetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
RR42_RS24620 -0.3
RR42_RS24630 -0.0
RR42_RS24640 +0.1
Catechol O-methyltransferase:
dopamine + S-adenosyl-L-methionine→3-methoxytyramine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Aryl sulfotransferase:
dopamine + 3'-phosphoadenylyl-sulfate→dopamine 3-O-sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Aldehyde dehydrogenase (NAD(+)):
3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O→(3,4-dihydroxyphenyl)acetate + NADH + 2 H+ (EC 1.2.1.3)
RR42_RS01275 +0.0
RR42_RS04280 -0.0
RR42_RS11360 -0.1
RR42_RS13660 +0.1
RR42_RS18500 -0.4
RR42_RS21485 +0.1
RR42_RS23750 -2.5
RR42_RS24065 -0.2
RR42_RS24390 +0.1
RR42_RS24705 +0.1
RR42_RS24840 -0.2
RR42_RS25005 +0.0
RR42_RS25010 +0.2
RR42_RS26255 -0.0
RR42_RS27350 -0.4
RR42_RS27780 +0.0
RR42_RS29955 -0.1
RR42_RS32140 -0.0
RR42_RS34255 -0.0
Catechol O-methyltransferase:
(3,4-dihydroxyphenyl)acetate + S-adenosyl-L-methionine→homovanillate + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information