MetaCyc Pathway: sphingosine and sphingosine-1-phosphate metabolism in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Reactions and Genes Carbon source Phenylacetic 2.5 mM
remove
Ceramidase:
an N-acylsphingosine + H2O→sphingosine + a fatty acid (EC 3.5.1.23)
No genes
Sphinganine kinase:
sphingosine + ATP→sphingosine 1-phosphate + ADP + H+ (EC 2.7.1.91)
No genes
sphingosine 1-phosphate + H2O→sphingosine + phosphate
No genes
sphingosine 1-phosphate→(2E)-hexadecenal + O-phosphoethanolamine
No genes
2-hexadecenal reductase (in reverse):
(2E)-hexadecenal + NADPH + H+→hexadecanal + NADP+ (EC 1.3.1.27)
No genes
Aldehyde dehydrogenase (NAD(+)):
(2E)-hexadecenal + NAD+ + H2O→(2E)-hexadecenoate + NADH + 2 H+ (EC 1.2.1.3)
RR42_RS01275 +0.0
RR42_RS04280 -0.0
RR42_RS11360 -0.1
RR42_RS13660 +0.1
RR42_RS18500 -0.4
RR42_RS21485 +0.1
RR42_RS23750 -2.5
RR42_RS24065 -0.2
RR42_RS24390 +0.1
RR42_RS24705 +0.1
RR42_RS24840 -0.2
RR42_RS25005 +0.0
RR42_RS25010 +0.2
RR42_RS26255 -0.0
RR42_RS27350 -0.4
RR42_RS27780 +0.0
RR42_RS29955 -0.1
RR42_RS32140 -0.0
RR42_RS34255 -0.0
Aldehyde dehydrogenase (NAD(+)):
hexadecanal + NAD+ + H2O→palmitate + NADH + 2 H+ (EC 1.2.1.3)
RR42_RS01275 +0.0
RR42_RS04280 -0.0
RR42_RS11360 -0.1
RR42_RS13660 +0.1
RR42_RS18500 -0.4
RR42_RS21485 +0.1
RR42_RS23750 -2.5
RR42_RS24065 -0.2
RR42_RS24390 +0.1
RR42_RS24705 +0.1
RR42_RS24840 -0.2
RR42_RS25005 +0.0
RR42_RS25010 +0.2
RR42_RS26255 -0.0
RR42_RS27350 -0.4
RR42_RS27780 +0.0
RR42_RS29955 -0.1
RR42_RS32140 -0.0
RR42_RS34255 -0.0
Long-chain-fatty-acid--CoA ligase:
(2E)-hexadecenoate + ATP + coenzyme A→(2E)-hexadec-2-enoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
RR42_RS01625 +0.1
RR42_RS18150 -0.1
RR42_RS18540 -0.1
RR42_RS25195 -0.1
RR42_RS26915 +0.1
RR42_RS28980 +0.0
RR42_RS29035 +0.0
RR42_RS29460 +0.0
RR42_RS29475 -0.0
RR42_RS36095 +0.1
RR42_RS36385 +0.0
RR42_RS36505 +0.2
Acyl-CoA dehydrogenase (NADP(+)) (in reverse):
(2E)-hexadec-2-enoyl-CoA + NADPH + H+→palmitoyl-CoA + NADP+ (EC 1.3.1.8)
No genes
Long-chain-fatty-acid--CoA ligase:
palmitate + ATP + coenzyme A→palmitoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
RR42_RS01625 +0.1
RR42_RS16170 -0.1
RR42_RS16600 +0.0
RR42_RS18150 -0.1
RR42_RS18540 -0.1
RR42_RS25195 -0.1
RR42_RS26915 +0.1
RR42_RS28980 +0.0
RR42_RS29035 +0.0
RR42_RS29460 +0.0
RR42_RS29475 -0.0
RR42_RS36095 +0.1
RR42_RS36385 +0.0
RR42_RS36505 +0.2

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information