MetaCyc Pathway: adipate degradation in Cupriavidus basilensis FW507-4G11

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Reactions and Genes Carbon source Phenylacetic 2.5 mM
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Succinate--CoA ligase (ADP-forming):
adipate + ATP + coenzyme A→adipoyl-CoA + ADP + phosphate (EC 6.2.1.5)
RR42_RS03095 -2.1
RR42_RS03100 N.D.
RR42_RS06560 N.D.
RR42_RS10005 -0.0
RR42_RS10010 -0.4
RR42_RS22965 -0.4
RR42_RS31375 +0.0
RR42_RS31380 +0.1
RR42_RS35920 -0.6
RR42_RS35925 -0.6
adipoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-5-carboxy-2-pentenoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)
RR42_RS01285 -0.0
RR42_RS02505 +0.2
RR42_RS10230 -0.3
RR42_RS11190 -0.0
RR42_RS21260 -0.1
RR42_RS21420 -1.5
RR42_RS24965 +0.1
RR42_RS25190 +0.0
Enoyl-CoA hydratase (in reverse):
(2E)-5-carboxy-2-pentenoyl-CoA + H2O→(3S)-hydroxyadipyl-CoA (EC 4.2.1.17)
RR42_RS00730 +0.2
RR42_RS02510 +0.0
RR42_RS02525 -0.1
RR42_RS03015 -0.1
RR42_RS04550 -0.2
RR42_RS05755 -0.1
RR42_RS05760 -2.6
RR42_RS07510 +0.2
RR42_RS10250 -0.5
RR42_RS10265 -0.2
RR42_RS10270 +0.2
RR42_RS11095 -0.4
RR42_RS12500 -0.1
RR42_RS12795 +0.4
RR42_RS13545 N.D.
RR42_RS16175 +0.5
RR42_RS16790 -0.2
RR42_RS18250 -1.5
RR42_RS18255 -0.5
RR42_RS19805 -0.2
RR42_RS19815 N.D.
RR42_RS22630 +0.0
RR42_RS22680 -0.8
RR42_RS23295 +0.4
RR42_RS23450 +0.1
RR42_RS23710 -0.3
RR42_RS24355 -0.1
RR42_RS24895 +0.0
RR42_RS25480 +0.4
RR42_RS25525 +0.0
RR42_RS25900 -0.1
RR42_RS28050 N.D.
RR42_RS28325 +0.1
RR42_RS28330 +0.5
RR42_RS28425 +0.0
RR42_RS28545 +0.5
RR42_RS28550 +0.2
RR42_RS29425 -0.3
RR42_RS29465 +0.1
RR42_RS29940 -0.0
RR42_RS29945 -0.0
RR42_RS31580 +0.3
RR42_RS31675 -0.2
RR42_RS31935 -0.0
RR42_RS31945 -0.1
RR42_RS34175 -0.3
RR42_RS34180 +0.1
RR42_RS34905 -0.1
RR42_RS35130 +0.2
RR42_RS35270 +0.0
RR42_RS36335 +0.3
RR42_RS36495 +0.4
3-hydroxyacyl-CoA dehydrogenase:
(3S)-hydroxyadipyl-CoA + NAD+→3-oxoadipoyl-CoA + NADH + H+ (EC 1.1.1.35)
RR42_RS02510 +0.0
RR42_RS03005 -0.4
RR42_RS03440 -0.2
RR42_RS05760 -2.6
RR42_RS10265 -0.2
RR42_RS11095 -0.4
RR42_RS22630 +0.0
RR42_RS25375 +0.2
RR42_RS28325 +0.1
RR42_RS29465 +0.1
RR42_RS31050 -0.5
RR42_RS35270 +0.0
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→succinyl-CoA + acetyl-CoA (EC 2.3.1.174)
RR42_RS35915 -2.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information