MetaCyc Pathway: 4-hydroxybenzoate biosynthesis III (plants) in Cupriavidus basilensis FW507-4G11

Reactions and Genes	Carbon source Phenylacetic 2.5 mM
4-coumarate--CoA ligase: 4-coumarate + ATP + coenzyme A→(E)-4-coumaroyl-CoA + AMP + diphosphate (EC 6.2.1.12)
RR42_RS36410	-0.0
(E)-4-coumaroyl-CoA + H2O→3S-(4-hydroxyphenyl)-3-hydroxy-propanoyl-CoA (EC 4.1.2.61)
No genes
3-hydroxyacyl-CoA dehydrogenase: 3S-(4-hydroxyphenyl)-3-hydroxy-propanoyl-CoA + NAD+→3-(4-hydroxyphenyl)-3-oxo-propanoyl-CoA + NADH + H+ (EC 1.1.1.35)
RR42_RS02510	+0.0
RR42_RS03005	-0.4
RR42_RS03440	-0.2
RR42_RS05760	-2.6
RR42_RS10265	-0.2
RR42_RS11095	-0.4
RR42_RS22630	+0.0
RR42_RS25375	+0.2
RR42_RS28325	+0.1
RR42_RS29465	+0.1
RR42_RS31050	-0.5
RR42_RS35270	+0.0
Acetyl-CoA C-acyltransferase (in reverse): 3-(4-hydroxyphenyl)-3-oxo-propanoyl-CoA + coenzyme A→4-hydroxybenzoyl-CoA + acetyl-CoA (EC 2.3.1.16)
RR42_RS00885	-0.4
RR42_RS02515	N.D.
RR42_RS03010	-0.1
RR42_RS07610	-0.5
RR42_RS07645	N.D.
RR42_RS10260	-0.0
RR42_RS10540	-0.5
RR42_RS11085	+0.3
RR42_RS16595	+0.1
RR42_RS22625	-0.2
RR42_RS24300	+0.1
RR42_RS24970	+0.1
RR42_RS25210	+0.0
RR42_RS25380	+0.2
RR42_RS25455	+0.1
RR42_RS26090	+0.1
RR42_RS27160	+0.3
RR42_RS28055	+0.2
RR42_RS31890	-0.3
RR42_RS31920	-0.9
RR42_RS35915	-2.0
RR42_RS36320	-0.5
RR42_RS37020	-0.1
4-hydroxybenzoyl-CoA thioesterase: 4-hydroxybenzoyl-CoA + H2O→4-hydroxybenzoate + coenzyme A + H+ (EC 3.1.2.23)
RR42_RS06545	+0.6
RR42_RS13530	+0.0

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information