MetaCyc Pathway: adipate biosynthesis in Cupriavidus basilensis FW507-4G11

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Reactions and Genes Carbon source Phenylacetic 2.5 mM
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3-oxoadipyl-CoA thiolase:
acetyl-CoA + succinyl-CoA→3-oxoadipoyl-CoA + coenzyme A (EC 2.3.1.174)
RR42_RS35915 -1.8
3-hydroxyacyl-CoA dehydrogenase (in reverse):
3-oxoadipoyl-CoA + NADH + H+→(3S)-hydroxyadipyl-CoA + NAD+ (EC 1.1.1.35)
RR42_RS02510 -0.0
RR42_RS03005 -0.6
RR42_RS03440 -0.1
RR42_RS05760 -2.7
RR42_RS10265 -0.0
RR42_RS11095 -0.5
RR42_RS22630 -0.2
RR42_RS25375 -0.4
RR42_RS28325 -0.0
RR42_RS29465 +0.1
RR42_RS31050 -0.4
RR42_RS35270 -0.1
Enoyl-CoA hydratase:
(3S)-hydroxyadipyl-CoA→(2E)-5-carboxy-2-pentenoyl-CoA + H2O (EC 4.2.1.17)
RR42_RS00730 +0.2
RR42_RS02510 -0.0
RR42_RS02525 -0.3
RR42_RS03015 -0.2
RR42_RS04550 +0.1
RR42_RS05755 -0.7
RR42_RS05760 -2.7
RR42_RS07510 +0.0
RR42_RS10250 +0.2
RR42_RS10265 -0.0
RR42_RS10270 -0.1
RR42_RS11095 -0.5
RR42_RS12500 +0.4
RR42_RS12795 -0.0
RR42_RS13545 N.D.
RR42_RS16175 +0.4
RR42_RS16790 -0.1
RR42_RS18250 -1.7
RR42_RS18255 -0.4
RR42_RS19805 -0.0
RR42_RS19815 N.D.
RR42_RS22630 -0.2
RR42_RS22680 -0.4
RR42_RS23295 +0.3
RR42_RS23450 +0.3
RR42_RS23710 -0.2
RR42_RS24355 -0.3
RR42_RS24895 -0.5
RR42_RS25480 -0.2
RR42_RS25525 -0.0
RR42_RS25900 +0.1
RR42_RS28050 N.D.
RR42_RS28325 -0.0
RR42_RS28330 +0.1
RR42_RS28425 -0.3
RR42_RS28545 +0.4
RR42_RS28550 +0.8
RR42_RS29425 -0.2
RR42_RS29465 +0.1
RR42_RS29940 +0.1
RR42_RS29945 -0.2
RR42_RS31580 +0.0
RR42_RS31675 -0.2
RR42_RS31935 +0.3
RR42_RS31945 +0.2
RR42_RS34175 +0.1
RR42_RS34180 -0.0
RR42_RS34905 -0.1
RR42_RS35130 -0.0
RR42_RS35270 -0.1
RR42_RS36335 +0.0
RR42_RS36495 +0.2
(2E)-5-carboxy-2-pentenoyl-CoA + FADH2→adipoyl-CoA + FAD + H+
RR42_RS16575 -0.3
Succinate--CoA ligase (ADP-forming) (in reverse):
adipoyl-CoA + ADP + phosphate→adipate + ATP + coenzyme A (EC 6.2.1.5)
RR42_RS03095 -1.4
RR42_RS03100 N.D.
RR42_RS06560 N.D.
RR42_RS10005 +0.2
RR42_RS10010 -0.5
RR42_RS22965 -0.3
RR42_RS31375 +0.1
RR42_RS31380 +0.1
RR42_RS35920 -0.6
RR42_RS35925 -0.9

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information