| Reactions and Genes | Protocatechuic Acid (C) |
|---|
| remove |
Mandelate racemase (in reverse):
(R)-mandelate→(S)-mandelate (EC 5.1.2.2) |
| RR42_RS23065 | -0.0 |
(S)-mandelate dehydrogenase:
(S)-mandelate + an oxidized electron carrier→phenylglyoxylate + a reduced two electron carrier (EC 1.1.99.31) |
| No genes |
Benzoylformate decarboxylase:
phenylglyoxylate + H+→benzaldehyde + CO2 (EC 4.1.1.7) |
| RR42_RS32970 | +5.0 |
Benzaldehyde dehydrogenase (NAD(+)):
benzaldehyde + NAD+ + H2O→benzoate + NADH + 2 H+ (EC 1.2.1.28) |
| No genes |
Benzaldehyde dehydrogenase (NADP(+)):
benzaldehyde + NADP+ + H2O→benzoate + NADPH + 2 H+ (EC 1.2.1.7) |
| No genes |
Benzoate 1,2-dioxygenase:
benzoate + NADH + dioxygen + H+→3,5-cyclohexadiene-1,2-diol-1-carboxylate + NAD+ (EC 1.14.12.10) |
| RR42_RS23490 | +0.0 |
| RR42_RS23495 | -0.5 |
| RR42_RS23500 | -0.2 |
1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase:
3,5-cyclohexadiene-1,2-diol-1-carboxylate + NAD+→catechol + CO2 + NADH (EC 1.3.1.25) |
| RR42_RS23485 | +0.1 |
Catechol 1,2-dioxygenase:
catechol + dioxygen→cis,cis-muconate + 2 H+ (EC 1.13.11.1) |
| RR42_RS23505 | -0.1 |
| RR42_RS32875 | -0.4 |
| RR42_RS32880 | +0.8 |
Catechol 2,3-dioxygenase:
catechol + dioxygen→(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H+ (EC 1.13.11.2) |
| RR42_RS32655 | +0.9 |
| RR42_RS34600 | -0.3 |
2-hydroxymuconate-semialdehyde hydrolase:
(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O→(2Z)-2-hydroxypenta-2,4-dienoate + formate + H+ (EC 3.7.1.9) |
| RR42_RS25595 | -0.5 |
| RR42_RS34060 | +0.8 |
Muconate cycloisomerase (in reverse):
cis,cis-muconate + H+→(+)-muconolactone (EC 5.5.1.1) |
| RR42_RS21835 | +0.8 |
2-oxopent-4-enoate hydratase (in reverse):
(2Z)-2-hydroxypenta-2,4-dienoate + H2O→(S)-4-hydroxy-2-oxopentanoate (EC 4.2.1.80) |
| RR42_RS05105 | N.D. |
| RR42_RS27885 | -0.5 |
| RR42_RS32645 | +0.7 |
| RR42_RS34355 | -0.6 |
Muconolactone Delta-isomerase:
(+)-muconolactone→(4,5-dihydro-5-oxofuran-2-yl)-acetate (EC 5.3.3.4) |
| RR42_RS10025 | -0.1 |
| RR42_RS10695 | -0.3 |
| RR42_RS21840 | +0.1 |
| RR42_RS33065 | +0.2 |
3-oxoadipate enol-lactonase:
(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O→3-oxoadipate + H+ (EC 3.1.1.24) |
| RR42_RS00755 | -0.6 |
| RR42_RS10565 | -0.0 |
| RR42_RS10690 | -0.1 |
| RR42_RS21850 | +0.9 |
| RR42_RS24710 | N.D. |
| RR42_RS30700 | -0.0 |
| RR42_RS32050 | -3.2 |
4-hydroxy-2-oxovalerate aldolase:
(S)-4-hydroxy-2-oxopentanoate→acetaldehyde + pyruvate (EC 4.1.3.39) |
| RR42_RS05095 | -0.1 |
| RR42_RS27900 | -0.0 |
| RR42_RS31860 | -0.2 |
| RR42_RS32625 | +0.2 |
3-oxoadipate CoA-transferase:
3-oxoadipate + succinyl-CoA→3-oxoadipoyl-CoA + succinate (EC 2.8.3.6) |
| RR42_RS10005 | +0.4 |
| RR42_RS10010 | -0.3 |
| RR42_RS22965 | +0.1 |
| RR42_RS22970 | +0.6 |
| RR42_RS31950 | +0.2 |
| RR42_RS31955 | +0.8 |
| RR42_RS35920 | -0.9 |
| RR42_RS35925 | -0.9 |
Acetaldehyde dehydrogenase (acetylating):
acetaldehyde + coenzyme A + NAD+→acetyl-CoA + NADH + H+ (EC 1.2.1.10) |
| RR42_RS05100 | +1.1 |
| RR42_RS27895 | +0.7 |
| RR42_RS31855 | +0.1 |
| RR42_RS32630 | +0.3 |
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→acetyl-CoA + succinyl-CoA (EC 2.3.1.174) |
| RR42_RS35915 | -1.9 |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information