Experiment set15S703 for Methanococcus maripaludis S2

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Formate 100 mM hypophosphite

Group: stress
Media: McCas_formate_complete + Sodium hypophosphite (100 mM), pH=7
Culturing: Methanococcus_S2_ML1, 5 mL Balch Tube, Anaerobic, at 37 (C), shaken=180 rpm
By: Leslie Day on 24-Jul
Media components: 2.5 g/L Sodium bicarbonate, 10.5 g/L Sodium Chloride, 1 g/L Ammonium chloride, 0.14 g/L Potassium phosphate dibasic, 0.0095 g/L Iron (II) chloride tetrahydrate, 0.001 g/L resazurin sodium salt, 0.84 g/L Sodium acetate, 13.6 g/L Sodium Formate, 2 g/L casamino acids, 0.5 g/L Dithiothreitol, 0.001 g/L Sodium sulfide nonahydrate, MOPS_2M_pH7 (0.002 M 3-(N-morpholino)propanesulfonic acid, 0.0005 M Sodium Hydroxide), Mc_general_salts_SO4free (0.335 g/L Potassium Chloride, 5.6 g/L Magnesium chloride hexahydrate, 0.105 g/L Calcium chloride), Mc_trace_minerals_SO4free (0.021 g/L Trisodium citrate dihydrate, 0.005 g/L Manganese (II) chloride tetrahydrate, 0.001 g/L Cobalt chloride hexahydrate, 0.001 g/L Zinc chloride, 0.0001 g/L copper (II) chloride dihydrate, 0.0001 g/L Aluminum chloride hydrate, 0.0001 g/L Boric Acid, 0.001 g/L Sodium Molybdate Dihydrate, 0.00025 g/L Nickel (II) chloride hexahydrate, 0.002 g/L Sodium selenate, 0.0001 g/L vanadium chloride, 3.3e-05 g/L Sodium tungstate dihydrate), Mc_vitamins (2e-05 g/L biotin, 2e-05 g/L Folic Acid, 0.0001 g/L Pyridoxine HCl, 5e-05 g/L Thiamine HCl, 5e-05 g/L Riboflavin, 5e-05 g/L Nicotinic Acid, 5e-05 g/L calcium pantothenate, 1e-06 g/L Cyanocobalamin, 5e-05 g/L 4-Aminobenzoic acid, 5e-05 g/L Lipoic acid)

Specific Phenotypes

For 25 genes in this experiment

For stress Sodium hypophosphite in Methanococcus maripaludis S2

For stress Sodium hypophosphite across organisms

SEED Subsystems

Subsystem #Specific
Selenocysteine metabolism 2
Wyeosine-MimG Biosynthesis 2
ZZ gjo need homes 2
Entner-Doudoroff Pathway 1
Glycolysis and Gluconeogenesis, including Archaeal enzymes 1
tRNA processing 1

Metabolic Maps

Color code by fitness: see overview map or list of maps.

Maps containing gene(s) with specific phenotypes:

MetaCyc Pathways

Pathways that contain genes with specific phenotypes:

Pathway #Steps #Present #Specific
guanine and guanosine salvage III 1 1 1
pseudouridine degradation 2 1 1
ribose phosphorylation 2 1 1
superpathway of guanine and guanosine salvage 3 3 1
adenine and adenosine salvage V 3 2 1
Entner-Doudoroff pathway III (semi-phosphorylative) 9 4 1
glycolysis V (Pyrococcus) 10 10 1
glycolysis IV 10 8 1
Rubisco shunt 10 8 1
photorespiration II 10 3 1
glycolysis II (from fructose 6-phosphate) 11 9 1
glycolysis III (from glucose) 11 8 1
glycolysis VI (from fructose) 11 7 1
homolactic fermentation 12 8 1
glycolysis I (from glucose 6-phosphate) 13 10 1
gluconeogenesis I 13 10 1
Bifidobacterium shunt 15 10 1
glycerol degradation to butanol 16 8 1
superpathway of glucose and xylose degradation 17 10 1
superpathway of glycolysis and the Entner-Doudoroff pathway 17 10 1
gluconeogenesis II (Methanobacterium thermoautotrophicum) 18 16 1
superpathway of hexitol degradation (bacteria) 18 10 1
superpathway of anaerobic sucrose degradation 19 13 1
hexitol fermentation to lactate, formate, ethanol and acetate 19 10 1
superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle 22 12 1
superpathway of N-acetylneuraminate degradation 22 10 1
ethene biosynthesis V (engineered) 25 12 1
photosynthetic 3-hydroxybutanoate biosynthesis (engineered) 26 14 1
superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass 26 13 1
1-butanol autotrophic biosynthesis (engineered) 27 14 1
Methanobacterium thermoautotrophicum biosynthetic metabolism 56 35 1