Experiment: KB with Paclitaxel 10 mM
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Psyr_1423 and Psyr_1424 are separated by 113 nucleotides Psyr_1424 and Psyr_1425 overlap by 14 nucleotides Psyr_1425 and Psyr_1426 are separated by 655 nucleotides
Psyr_1423: Psyr_1423 - Protein of unknown function DUF159, at 1,611,700 to 1,612,392
_1423
Psyr_1424: Psyr_1424 - Peptidase S24, S26A and S26B, at 1,612,506 to 1,612,940
_1424
Psyr_1425: Psyr_1425 - DNA-directed DNA polymerase, at 1,612,927 to 1,614,207
_1425
Psyr_1426: Psyr_1426 - conserved hypothetical protein, at 1,614,863 to 1,616,401
_1426
Position (kb) 1612
1613
1614
1615 Strain fitness (log2 ratio) -3
-2
-1
0
1
2
3
4 at 1612.002 kb on + strand, within Psyr_1423 at 1612.002 kb on + strand, within Psyr_1423 at 1612.002 kb on + strand, within Psyr_1423 at 1612.003 kb on - strand, within Psyr_1423 at 1612.003 kb on - strand, within Psyr_1423 at 1612.003 kb on - strand, within Psyr_1423 at 1612.012 kb on - strand, within Psyr_1423 at 1612.012 kb on - strand, within Psyr_1423 at 1612.032 kb on - strand, within Psyr_1423 at 1612.032 kb on - strand, within Psyr_1423 at 1612.273 kb on - strand, within Psyr_1423 at 1612.273 kb on - strand, within Psyr_1423 at 1612.286 kb on + strand, within Psyr_1423 at 1612.286 kb on + strand, within Psyr_1423 at 1612.286 kb on + strand, within Psyr_1423 at 1612.287 kb on - strand, within Psyr_1423 at 1612.287 kb on - strand, within Psyr_1423 at 1612.294 kb on + strand, within Psyr_1423 at 1612.491 kb on - strand at 1612.514 kb on - strand at 1612.605 kb on + strand, within Psyr_1424 at 1612.605 kb on + strand, within Psyr_1424 at 1612.628 kb on - strand, within Psyr_1424 at 1612.781 kb on + strand, within Psyr_1424 at 1612.848 kb on - strand, within Psyr_1424 at 1612.911 kb on + strand at 1612.911 kb on + strand at 1612.911 kb on + strand at 1612.911 kb on + strand at 1612.911 kb on + strand at 1612.911 kb on + strand at 1612.911 kb on + strand at 1612.911 kb on + strand at 1612.911 kb on + strand at 1612.911 kb on + strand at 1612.976 kb on - strand at 1612.976 kb on - strand at 1612.976 kb on - strand at 1612.976 kb on - strand at 1613.104 kb on + strand, within Psyr_1425 at 1613.161 kb on + strand, within Psyr_1425 at 1613.161 kb on + strand, within Psyr_1425 at 1613.161 kb on + strand, within Psyr_1425 at 1613.161 kb on + strand, within Psyr_1425 at 1613.161 kb on + strand, within Psyr_1425 at 1613.161 kb on + strand, within Psyr_1425 at 1613.161 kb on + strand, within Psyr_1425 at 1613.162 kb on - strand, within Psyr_1425 at 1613.162 kb on - strand, within Psyr_1425 at 1613.162 kb on - strand, within Psyr_1425 at 1613.162 kb on - strand, within Psyr_1425 at 1613.162 kb on - strand, within Psyr_1425 at 1613.162 kb on - strand, within Psyr_1425 at 1613.164 kb on - strand, within Psyr_1425 at 1613.171 kb on - strand, within Psyr_1425 at 1613.233 kb on + strand, within Psyr_1425 at 1613.233 kb on + strand, within Psyr_1425 at 1613.233 kb on + strand, within Psyr_1425 at 1613.233 kb on + strand, within Psyr_1425 at 1613.234 kb on - strand, within Psyr_1425 at 1613.234 kb on - strand, within Psyr_1425 at 1613.234 kb on - strand, within Psyr_1425 at 1613.319 kb on + strand, within Psyr_1425 at 1613.319 kb on + strand, within Psyr_1425 at 1613.320 kb on - strand, within Psyr_1425 at 1613.320 kb on - strand, within Psyr_1425 at 1613.320 kb on - strand, within Psyr_1425 at 1613.320 kb on - strand, within Psyr_1425 at 1613.320 kb on - strand, within Psyr_1425 at 1613.394 kb on + strand, within Psyr_1425 at 1613.394 kb on + strand, within Psyr_1425 at 1613.394 kb on + strand, within Psyr_1425 at 1613.412 kb on + strand, within Psyr_1425 at 1613.427 kb on - strand, within Psyr_1425 at 1613.427 kb on - strand, within Psyr_1425 at 1613.467 kb on - strand, within Psyr_1425 at 1613.470 kb on - strand, within Psyr_1425 at 1613.526 kb on + strand, within Psyr_1425 at 1613.526 kb on + strand, within Psyr_1425 at 1613.526 kb on + strand, within Psyr_1425 at 1613.527 kb on - strand, within Psyr_1425 at 1613.722 kb on - strand, within Psyr_1425 at 1613.743 kb on + strand, within Psyr_1425 at 1613.743 kb on + strand, within Psyr_1425 at 1613.743 kb on + strand, within Psyr_1425 at 1613.743 kb on + strand, within Psyr_1425 at 1613.743 kb on + strand, within Psyr_1425 at 1613.743 kb on + strand, within Psyr_1425 at 1613.743 kb on + strand, within Psyr_1425 at 1613.744 kb on - strand, within Psyr_1425 at 1613.744 kb on - strand, within Psyr_1425 at 1613.744 kb on - strand, within Psyr_1425 at 1613.744 kb on - strand, within Psyr_1425 at 1613.744 kb on - strand, within Psyr_1425 at 1613.744 kb on - strand, within Psyr_1425 at 1613.744 kb on - strand, within Psyr_1425 at 1613.744 kb on - strand, within Psyr_1425 at 1613.744 kb on - strand, within Psyr_1425 at 1613.744 kb on - strand, within Psyr_1425 at 1613.845 kb on + strand, within Psyr_1425 at 1613.845 kb on + strand, within Psyr_1425 at 1613.845 kb on + strand, within Psyr_1425 at 1613.846 kb on - strand, within Psyr_1425 at 1613.846 kb on - strand, within Psyr_1425 at 1613.846 kb on - strand, within Psyr_1425 at 1613.953 kb on + strand, within Psyr_1425 at 1614.004 kb on - strand, within Psyr_1425 at 1614.075 kb on + strand, within Psyr_1425 at 1614.099 kb on - strand at 1614.099 kb on - strand at 1614.135 kb on + strand at 1614.163 kb on + strand at 1614.165 kb on + strand at 1614.165 kb on + strand at 1614.165 kb on + strand at 1614.166 kb on - strand at 1614.166 kb on - strand at 1614.216 kb on + strand at 1614.217 kb on - strand at 1614.240 kb on + strand at 1614.240 kb on + strand at 1614.241 kb on - strand at 1614.241 kb on - strand at 1614.241 kb on - strand at 1614.241 kb on - strand at 1614.245 kb on + strand at 1614.246 kb on - strand at 1614.246 kb on - strand at 1614.246 kb on - strand at 1614.303 kb on + strand at 1614.345 kb on - strand at 1614.370 kb on + strand at 1614.371 kb on - strand at 1614.371 kb on - strand at 1614.374 kb on + strand at 1614.374 kb on + strand at 1614.374 kb on + strand at 1614.374 kb on + strand at 1614.374 kb on + strand at 1614.374 kb on + strand at 1614.375 kb on - strand at 1614.375 kb on - strand at 1614.375 kb on - strand at 1614.375 kb on - strand at 1614.375 kb on - strand at 1614.375 kb on - strand at 1614.375 kb on - strand at 1614.381 kb on - strand at 1614.382 kb on + strand at 1614.400 kb on + strand at 1614.400 kb on + strand at 1614.401 kb on - strand at 1614.408 kb on - strand at 1614.526 kb on + strand at 1614.526 kb on + strand at 1614.526 kb on + strand at 1614.526 kb on + strand at 1614.526 kb on + strand at 1614.526 kb on + strand at 1614.526 kb on + strand at 1614.526 kb on + strand at 1614.526 kb on + strand at 1614.526 kb on + strand at 1614.526 kb on + strand at 1614.526 kb on + strand at 1614.526 kb on + strand at 1614.527 kb on - strand at 1614.527 kb on - strand at 1614.527 kb on - strand at 1614.527 kb on - strand at 1614.527 kb on - strand at 1614.527 kb on - strand at 1614.527 kb on - strand at 1614.527 kb on - strand at 1614.527 kb on - strand at 1614.527 kb on - strand at 1614.527 kb on - strand at 1614.527 kb on - strand at 1614.527 kb on - strand at 1614.527 kb on - strand at 1614.527 kb on - strand at 1614.527 kb on - strand at 1614.527 kb on - strand at 1614.527 kb on - strand at 1614.528 kb on + strand at 1614.528 kb on + strand at 1614.528 kb on + strand at 1614.528 kb on + strand at 1614.529 kb on - strand at 1614.559 kb on + strand at 1614.560 kb on - strand at 1614.560 kb on - strand at 1614.618 kb on + strand at 1614.618 kb on + strand at 1614.644 kb on + strand at 1614.709 kb on + strand at 1614.709 kb on + strand at 1614.709 kb on + strand at 1614.709 kb on + strand at 1614.710 kb on - strand at 1614.710 kb on - strand at 1614.710 kb on - strand at 1614.710 kb on - strand at 1614.745 kb on + strand at 1614.745 kb on + strand at 1614.745 kb on + strand at 1614.745 kb on + strand at 1614.746 kb on - strand at 1614.767 kb on + strand at 1614.767 kb on + strand at 1614.767 kb on + strand at 1614.783 kb on + strand at 1614.783 kb on + strand at 1614.783 kb on + strand at 1614.784 kb on - strand at 1614.784 kb on - strand at 1614.784 kb on - strand at 1614.784 kb on - strand at 1614.785 kb on + strand at 1614.785 kb on + strand at 1614.785 kb on + strand at 1614.785 kb on + strand at 1614.785 kb on + strand at 1614.786 kb on - strand at 1614.786 kb on - strand at 1614.786 kb on - strand at 1614.786 kb on - strand at 1614.786 kb on - strand at 1614.786 kb on - strand at 1614.786 kb on - strand at 1614.789 kb on + strand at 1614.789 kb on + strand at 1614.790 kb on - strand at 1614.790 kb on - strand at 1614.790 kb on - strand at 1614.790 kb on - strand at 1614.790 kb on - strand at 1614.790 kb on - strand at 1614.864 kb on + strand at 1614.864 kb on + strand at 1614.864 kb on + strand at 1614.864 kb on + strand at 1614.893 kb on + strand at 1614.893 kb on + strand at 1614.893 kb on + strand at 1614.893 kb on + strand at 1614.893 kb on + strand at 1614.893 kb on + strand at 1614.894 kb on - strand at 1614.894 kb on - strand at 1614.894 kb on - strand at 1614.894 kb on - strand at 1614.894 kb on - strand at 1614.894 kb on - strand at 1614.894 kb on - strand at 1615.018 kb on + strand, within Psyr_1426 at 1615.018 kb on + strand, within Psyr_1426 at 1615.018 kb on + strand, within Psyr_1426 at 1615.018 kb on + strand, within Psyr_1426 at 1615.019 kb on - strand, within Psyr_1426 at 1615.019 kb on - strand, within Psyr_1426 at 1615.019 kb on - strand, within Psyr_1426 at 1615.019 kb on - strand, within Psyr_1426 at 1615.049 kb on + strand, within Psyr_1426 at 1615.049 kb on + strand, within Psyr_1426 at 1615.049 kb on + strand, within Psyr_1426 at 1615.049 kb on + strand, within Psyr_1426 at 1615.049 kb on + strand, within Psyr_1426 at 1615.050 kb on - strand, within Psyr_1426 at 1615.050 kb on - strand, within Psyr_1426 at 1615.050 kb on - strand, within Psyr_1426 at 1615.128 kb on + strand, within Psyr_1426 at 1615.128 kb on + strand, within Psyr_1426 at 1615.129 kb on - strand, within Psyr_1426 at 1615.150 kb on + strand, within Psyr_1426 at 1615.150 kb on + strand, within Psyr_1426 at 1615.150 kb on + strand, within Psyr_1426 at 1615.150 kb on + strand, within Psyr_1426 at 1615.151 kb on - strand, within Psyr_1426 at 1615.151 kb on - strand, within Psyr_1426 at 1615.151 kb on - strand, within Psyr_1426 at 1615.154 kb on + strand, within Psyr_1426
Per-strain Table
Position Strand Gene LocusTag Fraction KB with Paclitaxel 10 mM remove 1,612,002 + Psyr_1423 0.44 -0.3 1,612,002 + Psyr_1423 0.44 +0.0 1,612,002 + Psyr_1423 0.44 +0.1 1,612,003 - Psyr_1423 0.44 +0.6 1,612,003 - Psyr_1423 0.44 +1.1 1,612,003 - Psyr_1423 0.44 +0.7 1,612,012 - Psyr_1423 0.45 +1.4 1,612,012 - Psyr_1423 0.45 -0.3 1,612,032 - Psyr_1423 0.48 -2.2 1,612,032 - Psyr_1423 0.48 +0.2 1,612,273 - Psyr_1423 0.83 -1.1 1,612,273 - Psyr_1423 0.83 -1.7 1,612,286 + Psyr_1423 0.85 +0.8 1,612,286 + Psyr_1423 0.85 +0.3 1,612,286 + Psyr_1423 0.85 -0.4 1,612,287 - Psyr_1423 0.85 -2.2 1,612,287 - Psyr_1423 0.85 -0.3 1,612,294 + Psyr_1423 0.86 -1.2 1,612,491 - -0.1 1,612,514 - +0.9 1,612,605 + Psyr_1424 0.23 -1.1 1,612,605 + Psyr_1424 0.23 -0.3 1,612,628 - Psyr_1424 0.28 -1.3 1,612,781 + Psyr_1424 0.63 -0.5 1,612,848 - Psyr_1424 0.79 +1.6 1,612,911 + -0.9 1,612,911 + +2.0 1,612,911 + +0.0 1,612,911 + +0.9 1,612,911 + +0.8 1,612,911 + -0.3 1,612,911 + -0.1 1,612,911 + -1.4 1,612,911 + -0.1 1,612,911 + +0.6 1,612,976 - +0.4 1,612,976 - +1.1 1,612,976 - +0.8 1,612,976 - -0.3 1,613,104 + Psyr_1425 0.14 -0.3 1,613,161 + Psyr_1425 0.18 +0.2 1,613,161 + Psyr_1425 0.18 -1.0 1,613,161 + Psyr_1425 0.18 -0.3 1,613,161 + Psyr_1425 0.18 +0.1 1,613,161 + Psyr_1425 0.18 +0.7 1,613,161 + Psyr_1425 0.18 +0.3 1,613,161 + Psyr_1425 0.18 -0.0 1,613,162 - Psyr_1425 0.18 +0.2 1,613,162 - Psyr_1425 0.18 -1.0 1,613,162 - Psyr_1425 0.18 +0.1 1,613,162 - Psyr_1425 0.18 -0.9 1,613,162 - Psyr_1425 0.18 -0.8 1,613,162 - Psyr_1425 0.18 -0.6 1,613,164 - Psyr_1425 0.19 -1.4 1,613,171 - Psyr_1425 0.19 -0.3 1,613,233 + Psyr_1425 0.24 -0.1 1,613,233 + Psyr_1425 0.24 +0.1 1,613,233 + Psyr_1425 0.24 +0.0 1,613,233 + Psyr_1425 0.24 -0.3 1,613,234 - Psyr_1425 0.24 -1.0 1,613,234 - Psyr_1425 0.24 -0.2 1,613,234 - Psyr_1425 0.24 -0.0 1,613,319 + Psyr_1425 0.31 -0.2 1,613,319 + Psyr_1425 0.31 -1.3 1,613,320 - Psyr_1425 0.31 -1.6 1,613,320 - Psyr_1425 0.31 -0.9 1,613,320 - Psyr_1425 0.31 -1.9 1,613,320 - Psyr_1425 0.31 -1.6 1,613,320 - Psyr_1425 0.31 -1.1 1,613,394 + Psyr_1425 0.36 -1.5 1,613,394 + Psyr_1425 0.36 +0.3 1,613,394 + Psyr_1425 0.36 -2.2 1,613,412 + Psyr_1425 0.38 +0.5 1,613,427 - Psyr_1425 0.39 +0.3 1,613,427 - Psyr_1425 0.39 -0.8 1,613,467 - Psyr_1425 0.42 +0.3 1,613,470 - Psyr_1425 0.42 -0.3 1,613,526 + Psyr_1425 0.47 -0.1 1,613,526 + Psyr_1425 0.47 -1.3 1,613,526 + Psyr_1425 0.47 +0.3 1,613,527 - Psyr_1425 0.47 +0.7 1,613,722 - Psyr_1425 0.62 +4.7 1,613,743 + Psyr_1425 0.64 -0.7 1,613,743 + Psyr_1425 0.64 -0.9 1,613,743 + Psyr_1425 0.64 -0.3 1,613,743 + Psyr_1425 0.64 -0.6 1,613,743 + Psyr_1425 0.64 -1.9 1,613,743 + Psyr_1425 0.64 +0.8 1,613,743 + Psyr_1425 0.64 +0.8 1,613,744 - Psyr_1425 0.64 -1.1 1,613,744 - Psyr_1425 0.64 +0.5 1,613,744 - Psyr_1425 0.64 +1.6 1,613,744 - Psyr_1425 0.64 -1.9 1,613,744 - Psyr_1425 0.64 -2.0 1,613,744 - Psyr_1425 0.64 -0.4 1,613,744 - Psyr_1425 0.64 -1.6 1,613,744 - Psyr_1425 0.64 +0.1 1,613,744 - Psyr_1425 0.64 +1.5 1,613,744 - Psyr_1425 0.64 -0.1 1,613,845 + Psyr_1425 0.72 +0.1 1,613,845 + Psyr_1425 0.72 -2.3 1,613,845 + Psyr_1425 0.72 +1.1 1,613,846 - Psyr_1425 0.72 -1.4 1,613,846 - Psyr_1425 0.72 +1.1 1,613,846 - Psyr_1425 0.72 +0.1 1,613,953 + Psyr_1425 0.80 +0.1 1,614,004 - Psyr_1425 0.84 -0.1 1,614,075 + Psyr_1425 0.90 -1.6 1,614,099 - +1.8 1,614,099 - -1.4 1,614,135 + -0.1 1,614,163 + +1.9 1,614,165 + -1.2 1,614,165 + +0.0 1,614,165 + -1.2 1,614,166 - +1.7 1,614,166 - -0.5 1,614,216 + -1.0 1,614,217 - -1.0 1,614,240 + +1.2 1,614,240 + +0.5 1,614,241 - -0.5 1,614,241 - -0.8 1,614,241 - +0.1 1,614,241 - -0.3 1,614,245 + -0.1 1,614,246 - -1.1 1,614,246 - +0.3 1,614,246 - +0.1 1,614,303 + -0.5 1,614,345 - +0.0 1,614,370 + -1.1 1,614,371 - -1.0 1,614,371 - +0.7 1,614,374 + -0.5 1,614,374 + -1.4 1,614,374 + +0.4 1,614,374 + -0.1 1,614,374 + -0.1 1,614,374 + -0.8 1,614,375 - -1.5 1,614,375 - +0.1 1,614,375 - -1.1 1,614,375 - +0.1 1,614,375 - -0.6 1,614,375 - +1.8 1,614,375 - +1.3 1,614,381 - -0.4 1,614,382 + -1.7 1,614,400 + +1.5 1,614,400 + +0.2 1,614,401 - -0.1 1,614,408 - +2.3 1,614,526 + +1.0 1,614,526 + +0.8 1,614,526 + +0.3 1,614,526 + -1.0 1,614,526 + -0.3 1,614,526 + +2.1 1,614,526 + -0.4 1,614,526 + +0.3 1,614,526 + -1.9 1,614,526 + +0.9 1,614,526 + -0.9 1,614,526 + -0.3 1,614,526 + -0.8 1,614,527 - -0.6 1,614,527 - -2.8 1,614,527 - -0.4 1,614,527 - -1.2 1,614,527 - -1.7 1,614,527 - +2.7 1,614,527 - +2.0 1,614,527 - -0.4 1,614,527 - -1.4 1,614,527 - -0.7 1,614,527 - -0.3 1,614,527 - -1.2 1,614,527 - -0.2 1,614,527 - -0.0 1,614,527 - -2.8 1,614,527 - +0.1 1,614,527 - -0.5 1,614,527 - -1.6 1,614,528 + +1.1 1,614,528 + -3.7 1,614,528 + -0.1 1,614,528 + -0.6 1,614,529 - -0.6 1,614,559 + +0.8 1,614,560 - -2.2 1,614,560 - -1.1 1,614,618 + +0.3 1,614,618 + -1.5 1,614,644 + -0.2 1,614,709 + +1.5 1,614,709 + +0.7 1,614,709 + +1.5 1,614,709 + +0.8 1,614,710 - +0.1 1,614,710 - -0.9 1,614,710 - +2.3 1,614,710 - +0.4 1,614,745 + +1.5 1,614,745 + +1.6 1,614,745 + -1.3 1,614,745 + +1.3 1,614,746 - -1.4 1,614,767 + -0.3 1,614,767 + -0.6 1,614,767 + -1.0 1,614,783 + +0.3 1,614,783 + -2.9 1,614,783 + -0.7 1,614,784 - -0.8 1,614,784 - -0.4 1,614,784 - +1.5 1,614,784 - -0.1 1,614,785 + +0.4 1,614,785 + -1.2 1,614,785 + -0.9 1,614,785 + +1.7 1,614,785 + -0.2 1,614,786 - -3.3 1,614,786 - -0.7 1,614,786 - -1.6 1,614,786 - +0.3 1,614,786 - +1.4 1,614,786 - +1.3 1,614,786 - +1.7 1,614,789 + -0.5 1,614,789 + -0.2 1,614,790 - -0.8 1,614,790 - -1.3 1,614,790 - -0.1 1,614,790 - +0.3 1,614,790 - -1.2 1,614,790 - +1.8 1,614,864 + -0.2 1,614,864 + +0.1 1,614,864 + +0.2 1,614,864 + -0.5 1,614,893 + +1.6 1,614,893 + +1.6 1,614,893 + -1.2 1,614,893 + -1.3 1,614,893 + -1.7 1,614,893 + -1.3 1,614,894 - +0.8 1,614,894 - -0.9 1,614,894 - -0.3 1,614,894 - -0.0 1,614,894 - -1.1 1,614,894 - +0.8 1,614,894 - -0.4 1,615,018 + Psyr_1426 0.10 -0.3 1,615,018 + Psyr_1426 0.10 +0.6 1,615,018 + Psyr_1426 0.10 +0.9 1,615,018 + Psyr_1426 0.10 -0.2 1,615,019 - Psyr_1426 0.10 +1.3 1,615,019 - Psyr_1426 0.10 -3.2 1,615,019 - Psyr_1426 0.10 +0.3 1,615,019 - Psyr_1426 0.10 -0.0 1,615,049 + Psyr_1426 0.12 +1.3 1,615,049 + Psyr_1426 0.12 -0.7 1,615,049 + Psyr_1426 0.12 +0.5 1,615,049 + Psyr_1426 0.12 -1.3 1,615,049 + Psyr_1426 0.12 +0.3 1,615,050 - Psyr_1426 0.12 +0.7 1,615,050 - Psyr_1426 0.12 -0.6 1,615,050 - Psyr_1426 0.12 -0.3 1,615,128 + Psyr_1426 0.17 +3.3 1,615,128 + Psyr_1426 0.17 -2.1 1,615,129 - Psyr_1426 0.17 +1.3 1,615,150 + Psyr_1426 0.19 +0.3 1,615,150 + Psyr_1426 0.19 +0.8 1,615,150 + Psyr_1426 0.19 -1.9 1,615,150 + Psyr_1426 0.19 -1.9 1,615,151 - Psyr_1426 0.19 -1.3 1,615,151 - Psyr_1426 0.19 -0.5 1,615,151 - Psyr_1426 0.19 -0.1 1,615,154 + Psyr_1426 0.19 +0.2
Or see this region's nucleotide sequence