Experiment: sodium fluoride 15 mM
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Pf6N2E2_3841 and Pf6N2E2_3842 overlap by 1 nucleotides Pf6N2E2_3842 and Pf6N2E2_3843 are separated by 281 nucleotides Pf6N2E2_3843 and Pf6N2E2_3844 are separated by 261 nucleotides Pf6N2E2_3844 and Pf6N2E2_3845 are separated by 270 nucleotides
Pf6N2E2_3841 - Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-), at 4,473,204 to 4,473,842
_3841
Pf6N2E2_3842 - Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19), at 4,473,842 to 4,474,435
_3842
Pf6N2E2_3843 - MFS permease, at 4,474,717 to 4,476,378
_3843
Pf6N2E2_3844 - hypothetical protein, at 4,476,640 to 4,477,038
_3844
Pf6N2E2_3845 - A/G-specific adenine glycosylase (EC 3.2.2.-), at 4,477,309 to 4,479,540
_3845
Position (kb)
4474
4475
4476
4477 Strain fitness (log2 ratio)
-2
-1
0
1
2
3
4 at 4473.844 kb on - strand at 4473.859 kb on + strand at 4473.859 kb on + strand at 4473.860 kb on - strand at 4473.860 kb on - strand at 4473.860 kb on - strand at 4474.068 kb on + strand, within Pf6N2E2_3842 at 4474.068 kb on + strand, within Pf6N2E2_3842 at 4474.146 kb on + strand, within Pf6N2E2_3842 at 4474.146 kb on + strand, within Pf6N2E2_3842 at 4474.147 kb on - strand, within Pf6N2E2_3842 at 4474.147 kb on - strand, within Pf6N2E2_3842 at 4474.147 kb on - strand, within Pf6N2E2_3842 at 4474.216 kb on + strand, within Pf6N2E2_3842 at 4474.423 kb on + strand at 4474.423 kb on + strand at 4474.424 kb on - strand at 4474.424 kb on - strand at 4474.424 kb on - strand at 4474.477 kb on - strand at 4474.478 kb on + strand at 4474.479 kb on - strand at 4474.479 kb on - strand at 4474.479 kb on - strand at 4474.479 kb on - strand at 4474.479 kb on - strand at 4474.479 kb on - strand at 4474.550 kb on + strand at 4474.562 kb on + strand at 4474.562 kb on + strand at 4474.562 kb on + strand at 4474.562 kb on + strand at 4474.562 kb on + strand at 4474.562 kb on + strand at 4474.562 kb on + strand at 4474.563 kb on - strand at 4474.563 kb on - strand at 4474.563 kb on - strand at 4474.563 kb on - strand at 4474.563 kb on - strand at 4474.563 kb on - strand at 4474.563 kb on - strand at 4474.718 kb on + strand at 4474.913 kb on + strand, within Pf6N2E2_3843 at 4474.913 kb on + strand, within Pf6N2E2_3843 at 4474.913 kb on + strand, within Pf6N2E2_3843 at 4474.913 kb on + strand, within Pf6N2E2_3843 at 4474.913 kb on + strand, within Pf6N2E2_3843 at 4474.914 kb on - strand, within Pf6N2E2_3843 at 4474.914 kb on - strand, within Pf6N2E2_3843 at 4474.914 kb on - strand, within Pf6N2E2_3843 at 4474.914 kb on - strand, within Pf6N2E2_3843 at 4474.914 kb on - strand, within Pf6N2E2_3843 at 4474.980 kb on + strand, within Pf6N2E2_3843 at 4474.982 kb on + strand, within Pf6N2E2_3843 at 4474.982 kb on + strand, within Pf6N2E2_3843 at 4474.982 kb on + strand, within Pf6N2E2_3843 at 4474.982 kb on + strand, within Pf6N2E2_3843 at 4474.982 kb on + strand, within Pf6N2E2_3843 at 4474.982 kb on + strand, within Pf6N2E2_3843 at 4474.982 kb on + strand, within Pf6N2E2_3843 at 4474.982 kb on + strand, within Pf6N2E2_3843 at 4474.982 kb on + strand, within Pf6N2E2_3843 at 4474.982 kb on + strand, within Pf6N2E2_3843 at 4474.982 kb on + strand, within Pf6N2E2_3843 at 4474.982 kb on + strand, within Pf6N2E2_3843 at 4474.982 kb on + strand, within Pf6N2E2_3843 at 4474.982 kb on + strand, within Pf6N2E2_3843 at 4474.982 kb on + strand, within Pf6N2E2_3843 at 4474.982 kb on + strand, within Pf6N2E2_3843 at 4474.982 kb on + strand, within Pf6N2E2_3843 at 4474.982 kb on + strand, within Pf6N2E2_3843 at 4474.983 kb on - strand, within Pf6N2E2_3843 at 4474.983 kb on - strand, within Pf6N2E2_3843 at 4474.983 kb on - strand, within Pf6N2E2_3843 at 4474.983 kb on - strand, within Pf6N2E2_3843 at 4474.983 kb on - strand, within Pf6N2E2_3843 at 4474.983 kb on - strand, within Pf6N2E2_3843 at 4474.983 kb on - strand, within Pf6N2E2_3843 at 4474.983 kb on - strand, within Pf6N2E2_3843 at 4474.983 kb on - strand, within Pf6N2E2_3843 at 4474.983 kb on - strand, within Pf6N2E2_3843 at 4474.983 kb on - strand, within Pf6N2E2_3843 at 4474.983 kb on - strand, within Pf6N2E2_3843 at 4474.983 kb on - strand, within Pf6N2E2_3843 at 4474.983 kb on - strand, within Pf6N2E2_3843 at 4474.983 kb on - strand, within Pf6N2E2_3843 at 4474.983 kb on - strand, within Pf6N2E2_3843 at 4474.983 kb on - strand, within Pf6N2E2_3843 at 4474.983 kb on - strand, within Pf6N2E2_3843 at 4474.997 kb on + strand, within Pf6N2E2_3843 at 4474.997 kb on + strand, within Pf6N2E2_3843 at 4475.034 kb on - strand, within Pf6N2E2_3843 at 4475.034 kb on - strand, within Pf6N2E2_3843 at 4475.045 kb on + strand, within Pf6N2E2_3843 at 4475.046 kb on - strand, within Pf6N2E2_3843 at 4475.177 kb on + strand, within Pf6N2E2_3843 at 4475.178 kb on - strand, within Pf6N2E2_3843 at 4475.256 kb on - strand, within Pf6N2E2_3843 at 4475.256 kb on - strand, within Pf6N2E2_3843 at 4475.288 kb on + strand, within Pf6N2E2_3843 at 4475.288 kb on + strand, within Pf6N2E2_3843 at 4475.288 kb on + strand, within Pf6N2E2_3843 at 4475.309 kb on + strand, within Pf6N2E2_3843 at 4475.310 kb on - strand, within Pf6N2E2_3843 at 4475.310 kb on - strand, within Pf6N2E2_3843 at 4475.310 kb on - strand, within Pf6N2E2_3843 at 4475.512 kb on + strand, within Pf6N2E2_3843 at 4475.513 kb on - strand, within Pf6N2E2_3843 at 4475.513 kb on - strand, within Pf6N2E2_3843 at 4475.513 kb on - strand, within Pf6N2E2_3843 at 4475.536 kb on + strand, within Pf6N2E2_3843 at 4475.537 kb on - strand, within Pf6N2E2_3843 at 4475.537 kb on - strand, within Pf6N2E2_3843 at 4475.699 kb on + strand, within Pf6N2E2_3843 at 4475.699 kb on + strand, within Pf6N2E2_3843 at 4475.699 kb on + strand, within Pf6N2E2_3843 at 4475.699 kb on + strand, within Pf6N2E2_3843 at 4475.700 kb on - strand, within Pf6N2E2_3843 at 4475.700 kb on - strand, within Pf6N2E2_3843 at 4475.700 kb on - strand, within Pf6N2E2_3843 at 4475.732 kb on - strand, within Pf6N2E2_3843 at 4475.886 kb on + strand, within Pf6N2E2_3843 at 4475.886 kb on + strand, within Pf6N2E2_3843 at 4475.886 kb on + strand, within Pf6N2E2_3843 at 4475.886 kb on + strand, within Pf6N2E2_3843 at 4475.886 kb on + strand, within Pf6N2E2_3843 at 4475.886 kb on + strand, within Pf6N2E2_3843 at 4475.887 kb on - strand, within Pf6N2E2_3843 at 4475.887 kb on - strand, within Pf6N2E2_3843 at 4475.887 kb on - strand, within Pf6N2E2_3843 at 4475.887 kb on - strand, within Pf6N2E2_3843 at 4475.888 kb on + strand, within Pf6N2E2_3843 at 4475.888 kb on + strand, within Pf6N2E2_3843 at 4475.888 kb on + strand, within Pf6N2E2_3843 at 4475.888 kb on + strand, within Pf6N2E2_3843 at 4475.888 kb on + strand, within Pf6N2E2_3843 at 4475.888 kb on + strand, within Pf6N2E2_3843 at 4475.888 kb on + strand, within Pf6N2E2_3843 at 4475.889 kb on - strand, within Pf6N2E2_3843 at 4475.889 kb on - strand, within Pf6N2E2_3843 at 4475.889 kb on - strand, within Pf6N2E2_3843 at 4475.956 kb on - strand, within Pf6N2E2_3843 at 4475.957 kb on + strand, within Pf6N2E2_3843 at 4475.957 kb on + strand, within Pf6N2E2_3843 at 4475.957 kb on + strand, within Pf6N2E2_3843 at 4475.957 kb on + strand, within Pf6N2E2_3843 at 4475.957 kb on + strand, within Pf6N2E2_3843 at 4475.957 kb on + strand, within Pf6N2E2_3843 at 4475.957 kb on + strand, within Pf6N2E2_3843 at 4475.957 kb on + strand, within Pf6N2E2_3843 at 4475.957 kb on + strand, within Pf6N2E2_3843 at 4475.958 kb on - strand, within Pf6N2E2_3843 at 4475.958 kb on - strand, within Pf6N2E2_3843 at 4475.958 kb on - strand, within Pf6N2E2_3843 at 4475.958 kb on - strand, within Pf6N2E2_3843 at 4475.958 kb on - strand, within Pf6N2E2_3843 at 4475.958 kb on - strand, within Pf6N2E2_3843 at 4475.958 kb on - strand, within Pf6N2E2_3843 at 4475.958 kb on - strand, within Pf6N2E2_3843 at 4475.958 kb on - strand, within Pf6N2E2_3843 at 4475.958 kb on - strand, within Pf6N2E2_3843 at 4475.958 kb on - strand, within Pf6N2E2_3843 at 4475.961 kb on + strand, within Pf6N2E2_3843 at 4475.962 kb on - strand, within Pf6N2E2_3843 at 4475.962 kb on - strand, within Pf6N2E2_3843 at 4476.008 kb on - strand, within Pf6N2E2_3843 at 4476.095 kb on + strand, within Pf6N2E2_3843 at 4476.096 kb on - strand, within Pf6N2E2_3843 at 4476.096 kb on - strand, within Pf6N2E2_3843 at 4476.162 kb on + strand, within Pf6N2E2_3843 at 4476.163 kb on - strand, within Pf6N2E2_3843 at 4476.236 kb on + strand at 4476.383 kb on + strand at 4476.395 kb on - strand at 4476.455 kb on + strand at 4476.456 kb on - strand at 4476.456 kb on - strand at 4476.476 kb on - strand at 4476.522 kb on + strand at 4476.555 kb on + strand at 4476.742 kb on - strand, within Pf6N2E2_3844 at 4476.875 kb on + strand, within Pf6N2E2_3844 at 4476.875 kb on + strand, within Pf6N2E2_3844 at 4477.036 kb on + strand at 4477.036 kb on + strand at 4477.037 kb on - strand at 4477.037 kb on - strand at 4477.037 kb on - strand at 4477.037 kb on - strand at 4477.037 kb on - strand at 4477.040 kb on + strand at 4477.041 kb on - strand at 4477.041 kb on - strand at 4477.251 kb on + strand at 4477.251 kb on + strand at 4477.252 kb on - strand at 4477.264 kb on + strand at 4477.266 kb on + strand at 4477.267 kb on - strand at 4477.267 kb on - strand at 4477.267 kb on - strand at 4477.294 kb on + strand at 4477.294 kb on + strand at 4477.294 kb on + strand at 4477.294 kb on + strand at 4477.294 kb on + strand at 4477.295 kb on - strand at 4477.295 kb on - strand at 4477.295 kb on - strand at 4477.340 kb on + strand at 4477.340 kb on + strand at 4477.341 kb on - strand at 4477.341 kb on - strand
Per-strain Table
Position Strand Gene LocusTag Fraction sodium fluoride 15 mM remove 4,473,844 - +0.6 4,473,859 + +0.7 4,473,859 + +0.0 4,473,860 - +0.4 4,473,860 - +0.5 4,473,860 - +0.2 4,474,068 + Pf6N2E2_3842 0.38 -0.3 4,474,068 + Pf6N2E2_3842 0.38 +0.2 4,474,146 + Pf6N2E2_3842 0.51 +1.0 4,474,146 + Pf6N2E2_3842 0.51 -0.0 4,474,147 - Pf6N2E2_3842 0.51 -0.1 4,474,147 - Pf6N2E2_3842 0.51 +0.7 4,474,147 - Pf6N2E2_3842 0.51 +0.5 4,474,216 + Pf6N2E2_3842 0.63 +0.2 4,474,423 + +1.6 4,474,423 + +1.1 4,474,424 - +2.4 4,474,424 - +0.2 4,474,424 - +1.4 4,474,477 - -0.0 4,474,478 + +0.3 4,474,479 - -0.4 4,474,479 - -0.6 4,474,479 - -0.1 4,474,479 - +0.6 4,474,479 - +0.0 4,474,479 - -0.5 4,474,550 + +0.1 4,474,562 + +0.3 4,474,562 + +0.3 4,474,562 + +1.1 4,474,562 + +0.3 4,474,562 + +0.6 4,474,562 + +1.4 4,474,562 + -1.0 4,474,563 - +0.5 4,474,563 - +0.3 4,474,563 - +0.1 4,474,563 - -0.1 4,474,563 - -0.7 4,474,563 - +0.1 4,474,563 - +0.3 4,474,718 + +1.7 4,474,913 + Pf6N2E2_3843 0.12 +2.0 4,474,913 + Pf6N2E2_3843 0.12 +2.1 4,474,913 + Pf6N2E2_3843 0.12 +2.1 4,474,913 + Pf6N2E2_3843 0.12 +2.4 4,474,913 + Pf6N2E2_3843 0.12 +2.5 4,474,914 - Pf6N2E2_3843 0.12 +2.0 4,474,914 - Pf6N2E2_3843 0.12 +1.9 4,474,914 - Pf6N2E2_3843 0.12 +2.7 4,474,914 - Pf6N2E2_3843 0.12 +3.6 4,474,914 - Pf6N2E2_3843 0.12 +2.6 4,474,980 + Pf6N2E2_3843 0.16 +2.7 4,474,982 + Pf6N2E2_3843 0.16 +3.2 4,474,982 + Pf6N2E2_3843 0.16 +1.8 4,474,982 + Pf6N2E2_3843 0.16 +1.6 4,474,982 + Pf6N2E2_3843 0.16 +2.3 4,474,982 + Pf6N2E2_3843 0.16 +2.0 4,474,982 + Pf6N2E2_3843 0.16 +2.1 4,474,982 + Pf6N2E2_3843 0.16 +2.2 4,474,982 + Pf6N2E2_3843 0.16 +2.1 4,474,982 + Pf6N2E2_3843 0.16 +1.7 4,474,982 + Pf6N2E2_3843 0.16 +1.9 4,474,982 + Pf6N2E2_3843 0.16 +1.5 4,474,982 + Pf6N2E2_3843 0.16 +1.8 4,474,982 + Pf6N2E2_3843 0.16 +2.0 4,474,982 + Pf6N2E2_3843 0.16 +2.6 4,474,982 + Pf6N2E2_3843 0.16 +2.2 4,474,982 + Pf6N2E2_3843 0.16 +2.0 4,474,982 + Pf6N2E2_3843 0.16 +1.7 4,474,982 + Pf6N2E2_3843 0.16 +2.3 4,474,983 - Pf6N2E2_3843 0.16 +2.6 4,474,983 - Pf6N2E2_3843 0.16 +2.0 4,474,983 - Pf6N2E2_3843 0.16 +2.4 4,474,983 - Pf6N2E2_3843 0.16 +2.1 4,474,983 - Pf6N2E2_3843 0.16 +2.0 4,474,983 - Pf6N2E2_3843 0.16 +2.1 4,474,983 - Pf6N2E2_3843 0.16 +2.4 4,474,983 - Pf6N2E2_3843 0.16 +1.9 4,474,983 - Pf6N2E2_3843 0.16 +1.9 4,474,983 - Pf6N2E2_3843 0.16 +2.4 4,474,983 - Pf6N2E2_3843 0.16 +2.5 4,474,983 - Pf6N2E2_3843 0.16 +2.4 4,474,983 - Pf6N2E2_3843 0.16 +1.9 4,474,983 - Pf6N2E2_3843 0.16 +1.2 4,474,983 - Pf6N2E2_3843 0.16 +2.4 4,474,983 - Pf6N2E2_3843 0.16 +1.0 4,474,983 - Pf6N2E2_3843 0.16 +3.2 4,474,983 - Pf6N2E2_3843 0.16 +2.2 4,474,997 + Pf6N2E2_3843 0.17 +2.4 4,474,997 + Pf6N2E2_3843 0.17 +2.4 4,475,034 - Pf6N2E2_3843 0.19 +4.0 4,475,034 - Pf6N2E2_3843 0.19 +2.7 4,475,045 + Pf6N2E2_3843 0.20 +2.2 4,475,046 - Pf6N2E2_3843 0.20 +2.3 4,475,177 + Pf6N2E2_3843 0.28 +2.2 4,475,178 - Pf6N2E2_3843 0.28 +1.5 4,475,256 - Pf6N2E2_3843 0.32 +1.9 4,475,256 - Pf6N2E2_3843 0.32 +2.0 4,475,288 + Pf6N2E2_3843 0.34 +2.2 4,475,288 + Pf6N2E2_3843 0.34 +2.5 4,475,288 + Pf6N2E2_3843 0.34 +2.5 4,475,309 + Pf6N2E2_3843 0.36 +1.9 4,475,310 - Pf6N2E2_3843 0.36 +2.5 4,475,310 - Pf6N2E2_3843 0.36 +2.5 4,475,310 - Pf6N2E2_3843 0.36 +2.1 4,475,512 + Pf6N2E2_3843 0.48 +1.4 4,475,513 - Pf6N2E2_3843 0.48 +2.7 4,475,513 - Pf6N2E2_3843 0.48 +2.2 4,475,513 - Pf6N2E2_3843 0.48 +3.0 4,475,536 + Pf6N2E2_3843 0.49 +2.5 4,475,537 - Pf6N2E2_3843 0.49 +2.2 4,475,537 - Pf6N2E2_3843 0.49 +1.8 4,475,699 + Pf6N2E2_3843 0.59 +2.4 4,475,699 + Pf6N2E2_3843 0.59 +2.9 4,475,699 + Pf6N2E2_3843 0.59 +2.0 4,475,699 + Pf6N2E2_3843 0.59 +1.9 4,475,700 - Pf6N2E2_3843 0.59 +2.1 4,475,700 - Pf6N2E2_3843 0.59 +2.1 4,475,700 - Pf6N2E2_3843 0.59 +2.5 4,475,732 - Pf6N2E2_3843 0.61 +1.8 4,475,886 + Pf6N2E2_3843 0.70 +2.4 4,475,886 + Pf6N2E2_3843 0.70 +2.2 4,475,886 + Pf6N2E2_3843 0.70 +2.0 4,475,886 + Pf6N2E2_3843 0.70 +1.7 4,475,886 + Pf6N2E2_3843 0.70 +2.2 4,475,886 + Pf6N2E2_3843 0.70 +2.4 4,475,887 - Pf6N2E2_3843 0.70 +2.2 4,475,887 - Pf6N2E2_3843 0.70 +3.0 4,475,887 - Pf6N2E2_3843 0.70 +2.7 4,475,887 - Pf6N2E2_3843 0.70 +2.3 4,475,888 + Pf6N2E2_3843 0.70 +2.2 4,475,888 + Pf6N2E2_3843 0.70 +2.3 4,475,888 + Pf6N2E2_3843 0.70 +2.6 4,475,888 + Pf6N2E2_3843 0.70 +2.7 4,475,888 + Pf6N2E2_3843 0.70 +2.6 4,475,888 + Pf6N2E2_3843 0.70 +2.5 4,475,888 + Pf6N2E2_3843 0.70 +1.8 4,475,889 - Pf6N2E2_3843 0.71 +2.9 4,475,889 - Pf6N2E2_3843 0.71 +1.9 4,475,889 - Pf6N2E2_3843 0.71 +2.2 4,475,956 - Pf6N2E2_3843 0.75 +1.6 4,475,957 + Pf6N2E2_3843 0.75 +2.9 4,475,957 + Pf6N2E2_3843 0.75 +2.2 4,475,957 + Pf6N2E2_3843 0.75 +2.4 4,475,957 + Pf6N2E2_3843 0.75 +2.4 4,475,957 + Pf6N2E2_3843 0.75 +2.4 4,475,957 + Pf6N2E2_3843 0.75 +2.1 4,475,957 + Pf6N2E2_3843 0.75 +2.4 4,475,957 + Pf6N2E2_3843 0.75 +2.0 4,475,957 + Pf6N2E2_3843 0.75 +2.7 4,475,958 - Pf6N2E2_3843 0.75 +1.7 4,475,958 - Pf6N2E2_3843 0.75 +2.1 4,475,958 - Pf6N2E2_3843 0.75 +2.0 4,475,958 - Pf6N2E2_3843 0.75 +1.8 4,475,958 - Pf6N2E2_3843 0.75 +2.2 4,475,958 - Pf6N2E2_3843 0.75 +2.0 4,475,958 - Pf6N2E2_3843 0.75 +2.5 4,475,958 - Pf6N2E2_3843 0.75 +2.0 4,475,958 - Pf6N2E2_3843 0.75 +2.1 4,475,958 - Pf6N2E2_3843 0.75 +1.9 4,475,958 - Pf6N2E2_3843 0.75 +3.0 4,475,961 + Pf6N2E2_3843 0.75 +4.6 4,475,962 - Pf6N2E2_3843 0.75 +2.7 4,475,962 - Pf6N2E2_3843 0.75 +1.6 4,476,008 - Pf6N2E2_3843 0.78 +1.2 4,476,095 + Pf6N2E2_3843 0.83 +2.3 4,476,096 - Pf6N2E2_3843 0.83 +2.5 4,476,096 - Pf6N2E2_3843 0.83 +2.7 4,476,162 + Pf6N2E2_3843 0.87 +2.0 4,476,163 - Pf6N2E2_3843 0.87 +2.8 4,476,236 + +2.8 4,476,383 + +2.6 4,476,395 - -2.7 4,476,455 + +2.2 4,476,456 - -1.7 4,476,456 - -2.5 4,476,476 - -2.2 4,476,522 + +2.7 4,476,555 + +1.8 4,476,742 - Pf6N2E2_3844 0.26 -0.4 4,476,875 + Pf6N2E2_3844 0.59 +0.7 4,476,875 + Pf6N2E2_3844 0.59 +1.4 4,477,036 + +1.9 4,477,036 + +0.8 4,477,037 - -2.3 4,477,037 - -1.2 4,477,037 - -0.7 4,477,037 - -0.2 4,477,037 - -1.0 4,477,040 + +0.2 4,477,041 - -1.3 4,477,041 - -1.3 4,477,251 + -0.3 4,477,251 + -0.2 4,477,252 - -1.6 4,477,264 + +0.3 4,477,266 + -1.0 4,477,267 - +0.2 4,477,267 - -0.7 4,477,267 - +0.1 4,477,294 + -0.0 4,477,294 + +1.3 4,477,294 + +0.9 4,477,294 + +0.8 4,477,294 + +0.9 4,477,295 - -0.5 4,477,295 - -1.0 4,477,295 - -0.6 4,477,340 + +0.7 4,477,340 + +0.0 4,477,341 - +0.2 4,477,341 - +0.0
Or see this region's nucleotide sequence