Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3755c

Experiment: 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3754 and Rv3755c overlap by 38 nucleotidesRv3755c and Rv3756c are separated by 5 nucleotidesRv3756c and Rv3757c overlap by 4 nucleotides Rv3754: Rv3754 - Prephenate dehydrogenase TyrA (PDH) (hydroxyphenylpyruvate synthase), at 4,200,421 to 4,201,326 Rv3754 Rv3755c: Rv3755c - Conserved protein, at 4,201,289 to 4,201,888 Rv3755c Rv3756c: Rv3756c - Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProZ, at 4,201,894 to 4,202,613 Rv3756c Rv3757c: Rv3757c - Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProW, at 4,202,610 to 4,203,299 Rv3757c Position (kb) 4201 4202Strain fitness (log2 ratio) -2 -1 0 1 2at 4200.334 kb on + strandat 4200.334 kb on + strandat 4200.335 kb on - strandat 4200.338 kb on + strandat 4200.338 kb on + strandat 4200.338 kb on + strandat 4200.339 kb on - strandat 4200.339 kb on - strandat 4201.405 kb on + strand, within Rv3755cat 4201.405 kb on + strand, within Rv3755cat 4201.407 kb on + strand, within Rv3755cat 4201.408 kb on - strand, within Rv3755cat 4201.448 kb on + strand, within Rv3755cat 4201.452 kb on + strand, within Rv3755cat 4201.452 kb on + strand, within Rv3755cat 4201.453 kb on - strand, within Rv3755cat 4201.563 kb on + strand, within Rv3755cat 4201.563 kb on + strand, within Rv3755cat 4201.563 kb on + strand, within Rv3755cat 4201.564 kb on - strand, within Rv3755cat 4201.564 kb on - strand, within Rv3755cat 4201.564 kb on - strand, within Rv3755cat 4201.652 kb on + strand, within Rv3755cat 4201.710 kb on + strand, within Rv3755cat 4201.895 kb on + strandat 4202.091 kb on - strand, within Rv3756cat 4202.091 kb on - strand, within Rv3756cat 4202.164 kb on + strand, within Rv3756cat 4202.198 kb on - strand, within Rv3756cat 4202.198 kb on - strand, within Rv3756cat 4202.198 kb on - strand, within Rv3756cat 4202.198 kb on - strand, within Rv3756cat 4202.314 kb on - strand, within Rv3756cat 4202.363 kb on - strand, within Rv3756cat 4202.516 kb on + strand, within Rv3756cat 4202.586 kb on - strandat 4202.586 kb on - strandat 4202.827 kb on - strand, within Rv3757cat 4202.827 kb on - strand, within Rv3757c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5
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4,200,334 + +0.2
4,200,334 + -1.2
4,200,335 - +0.1
4,200,338 + -0.4
4,200,338 + -0.3
4,200,338 + -1.8
4,200,339 - +0.2
4,200,339 - +0.6
4,201,405 + Rv3755c 0.19 -0.7
4,201,405 + Rv3755c 0.19 -1.8
4,201,407 + Rv3755c 0.20 +0.8
4,201,408 - Rv3755c 0.20 +1.2
4,201,448 + Rv3755c 0.27 -0.5
4,201,452 + Rv3755c 0.27 +0.2
4,201,452 + Rv3755c 0.27 -0.7
4,201,453 - Rv3755c 0.27 -0.7
4,201,563 + Rv3755c 0.46 -1.1
4,201,563 + Rv3755c 0.46 -0.4
4,201,563 + Rv3755c 0.46 -0.6
4,201,564 - Rv3755c 0.46 -1.4
4,201,564 - Rv3755c 0.46 -1.1
4,201,564 - Rv3755c 0.46 +0.2
4,201,652 + Rv3755c 0.60 -0.5
4,201,710 + Rv3755c 0.70 +0.5
4,201,895 + -2.0
4,202,091 - Rv3756c 0.27 -0.1
4,202,091 - Rv3756c 0.27 -0.4
4,202,164 + Rv3756c 0.38 +1.8
4,202,198 - Rv3756c 0.42 -0.4
4,202,198 - Rv3756c 0.42 +1.8
4,202,198 - Rv3756c 0.42 -1.0
4,202,198 - Rv3756c 0.42 +0.3
4,202,314 - Rv3756c 0.58 +0.1
4,202,363 - Rv3756c 0.65 +0.1
4,202,516 + Rv3756c 0.86 -2.7
4,202,586 - -0.3
4,202,586 - -0.4
4,202,827 - Rv3757c 0.31 +0.4
4,202,827 - Rv3757c 0.31 +0.5

Or see this region's nucleotide sequence