Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3595c

Experiment: 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3594 and Rv3595c are separated by 46 nucleotidesRv3595c and Rv3596c are separated by 107 nucleotides Rv3594: Rv3594 - Conserved hypothetical protein, at 4,035,857 to 4,036,684 Rv3594 Rv3595c: Rv3595c - PE-PGRS family protein PE_PGRS59, at 4,036,731 to 4,038,050 Rv3595c Rv3596c: Rv3596c - Probable ATP-dependent protease ATP-binding subunit ClpC1, at 4,038,158 to 4,040,704 Rv3596c Position (kb) 4036 4037 4038 4039Strain fitness (log2 ratio) -2 -1 0 1 2at 4035.897 kb on + strandat 4036.092 kb on + strand, within Rv3594at 4036.337 kb on + strand, within Rv3594at 4036.337 kb on + strand, within Rv3594at 4036.338 kb on - strand, within Rv3594at 4036.539 kb on + strand, within Rv3594at 4036.539 kb on + strand, within Rv3594at 4036.540 kb on - strand, within Rv3594at 4036.540 kb on - strand, within Rv3594at 4036.615 kb on + strandat 4036.616 kb on - strandat 4036.616 kb on - strandat 4036.872 kb on - strand, within Rv3595cat 4036.907 kb on + strand, within Rv3595cat 4036.907 kb on + strand, within Rv3595cat 4036.908 kb on - strand, within Rv3595cat 4037.304 kb on - strand, within Rv3595cat 4037.454 kb on - strand, within Rv3595cat 4037.495 kb on - strand, within Rv3595cat 4037.495 kb on - strand, within Rv3595cat 4037.631 kb on - strand, within Rv3595cat 4037.644 kb on + strand, within Rv3595cat 4037.791 kb on + strand, within Rv3595cat 4037.791 kb on + strand, within Rv3595cat 4037.792 kb on - strand, within Rv3595cat 4037.792 kb on - strand, within Rv3595cat 4037.866 kb on + strand, within Rv3595cat 4038.097 kb on + strandat 4038.097 kb on + strandat 4038.098 kb on - strandat 4038.098 kb on - strandat 4038.134 kb on - strandat 4038.136 kb on + strandat 4038.151 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5
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4,035,897 + +0.8
4,036,092 + Rv3594 0.28 +0.2
4,036,337 + Rv3594 0.58 +0.9
4,036,337 + Rv3594 0.58 -0.7
4,036,338 - Rv3594 0.58 +1.0
4,036,539 + Rv3594 0.82 +0.3
4,036,539 + Rv3594 0.82 +1.8
4,036,540 - Rv3594 0.82 +0.5
4,036,540 - Rv3594 0.82 -0.4
4,036,615 + -1.4
4,036,616 - -0.1
4,036,616 - -0.8
4,036,872 - Rv3595c 0.11 +0.4
4,036,907 + Rv3595c 0.13 -0.3
4,036,907 + Rv3595c 0.13 +0.8
4,036,908 - Rv3595c 0.13 -0.6
4,037,304 - Rv3595c 0.43 +0.5
4,037,454 - Rv3595c 0.55 +0.5
4,037,495 - Rv3595c 0.58 -1.1
4,037,495 - Rv3595c 0.58 -1.5
4,037,631 - Rv3595c 0.68 +0.2
4,037,644 + Rv3595c 0.69 +0.6
4,037,791 + Rv3595c 0.80 -0.4
4,037,791 + Rv3595c 0.80 +1.9
4,037,792 - Rv3595c 0.80 -0.1
4,037,792 - Rv3595c 0.80 +0.3
4,037,866 + Rv3595c 0.86 +0.1
4,038,097 + -0.6
4,038,097 + -0.9
4,038,098 - -2.0
4,038,098 - -0.8
4,038,134 - -0.4
4,038,136 + -0.9
4,038,151 + -0.2

Or see this region's nucleotide sequence