Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3463

Experiment: 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3460c and Rv3461c are separated by 215 nucleotidesRv3461c and Rv3462c are separated by 32 nucleotidesRv3462c and Rv3463 are separated by 253 nucleotidesRv3463 and Rv3464 are separated by 72 nucleotides Rv3460c: Rv3460c - 30S ribosomal protein S13 RpsM, at 3,879,696 to 3,880,070 Rv3460c Rv3461c: Rv3461c - 50S ribosomal protein L36 RpmJ, at 3,880,286 to 3,880,399 Rv3461c Rv3462c: Rv3462c - Probable translation initiation factor if-1 InfA, at 3,880,432 to 3,880,653 Rv3462c Rv3463: Rv3463 - Conserved protein, at 3,880,907 to 3,881,764 Rv3463 Rv3464: Rv3464 - dTDP-glucose 4,6-dehydratase RmlB, at 3,881,837 to 3,882,832 Rv3464 Position (kb) 3880 3881 3882Strain fitness (log2 ratio) -2 -1 0 1at 3880.720 kb on - strandat 3880.946 kb on - strandat 3881.238 kb on - strand, within Rv3463at 3881.250 kb on - strand, within Rv3463at 3881.267 kb on + strand, within Rv3463at 3881.271 kb on + strand, within Rv3463at 3881.378 kb on + strand, within Rv3463at 3881.379 kb on - strand, within Rv3463at 3881.454 kb on - strand, within Rv3463at 3881.513 kb on - strand, within Rv3463at 3881.516 kb on + strand, within Rv3463at 3881.517 kb on - strand, within Rv3463at 3881.517 kb on - strand, within Rv3463at 3881.534 kb on + strand, within Rv3463at 3881.534 kb on + strand, within Rv3463at 3881.690 kb on - strandat 3881.825 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5
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3,880,720 - -0.4
3,880,946 - +0.6
3,881,238 - Rv3463 0.39 +0.0
3,881,250 - Rv3463 0.40 -0.6
3,881,267 + Rv3463 0.42 +0.1
3,881,271 + Rv3463 0.42 -1.5
3,881,378 + Rv3463 0.55 -1.9
3,881,379 - Rv3463 0.55 -0.7
3,881,454 - Rv3463 0.64 -0.8
3,881,513 - Rv3463 0.71 -0.5
3,881,516 + Rv3463 0.71 -0.3
3,881,517 - Rv3463 0.71 -0.9
3,881,517 - Rv3463 0.71 -0.5
3,881,534 + Rv3463 0.73 -1.3
3,881,534 + Rv3463 0.73 +1.7
3,881,690 - -0.9
3,881,825 - -0.7

Or see this region's nucleotide sequence