Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1207

Experiment: 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1206 and Rv1207 are separated by 65 nucleotidesRv1207 and Rv1208 overlap by 4 nucleotides Rv1206: Rv1206 - Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase), at 1,349,332 to 1,351,125 Rv1206 Rv1207: Rv1207 - Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2), at 1,351,191 to 1,352,147 Rv1207 Rv1208: Rv1208 - Probable glucosyl-3-phosphoglycerate synthase GpgS, at 1,352,144 to 1,353,118 Rv1208 Position (kb) 1351 1352 1353Strain fitness (log2 ratio) -2 -1 0 1at 1350.236 kb on - strand, within Rv1206at 1350.461 kb on - strand, within Rv1206at 1350.800 kb on - strand, within Rv1206at 1350.902 kb on - strand, within Rv1206at 1351.036 kb on + strandat 1351.036 kb on + strandat 1351.040 kb on + strandat 1351.041 kb on - strandat 1351.041 kb on - strandat 1351.063 kb on + strandat 1351.063 kb on + strandat 1351.063 kb on + strandat 1351.064 kb on - strandat 1351.072 kb on + strandat 1351.072 kb on + strandat 1351.073 kb on - strandat 1351.075 kb on + strandat 1351.084 kb on + strandat 1351.085 kb on - strandat 1351.183 kb on - strandat 1351.734 kb on + strand, within Rv1207at 1351.734 kb on + strand, within Rv1207at 1351.734 kb on + strand, within Rv1207at 1351.735 kb on - strand, within Rv1207at 1351.735 kb on - strand, within Rv1207at 1351.740 kb on - strand, within Rv1207at 1351.740 kb on - strand, within Rv1207at 1351.773 kb on - strand, within Rv1207at 1351.910 kb on + strand, within Rv1207at 1351.910 kb on + strand, within Rv1207at 1351.911 kb on - strand, within Rv1207at 1353.139 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5
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1,350,236 - Rv1206 0.50 -0.1
1,350,461 - Rv1206 0.63 -0.7
1,350,800 - Rv1206 0.82 +0.0
1,350,902 - Rv1206 0.88 -2.2
1,351,036 + +0.8
1,351,036 + -0.1
1,351,040 + -1.3
1,351,041 - +0.1
1,351,041 - -0.0
1,351,063 + +0.2
1,351,063 + +0.0
1,351,063 + +0.4
1,351,064 - -0.4
1,351,072 + +0.4
1,351,072 + -0.1
1,351,073 - -0.3
1,351,075 + -0.6
1,351,084 + -0.4
1,351,085 - +0.6
1,351,183 - -0.3
1,351,734 + Rv1207 0.57 -1.5
1,351,734 + Rv1207 0.57 -0.7
1,351,734 + Rv1207 0.57 -0.3
1,351,735 - Rv1207 0.57 -0.9
1,351,735 - Rv1207 0.57 -0.5
1,351,740 - Rv1207 0.57 -0.9
1,351,740 - Rv1207 0.57 -2.2
1,351,773 - Rv1207 0.61 -1.7
1,351,910 + Rv1207 0.75 -0.8
1,351,910 + Rv1207 0.75 -2.5
1,351,911 - Rv1207 0.75 -2.1
1,353,139 + -2.0

Or see this region's nucleotide sequence