Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2116

Experiment: 7H9 with nitrite 1.5 mM; pH 5.5

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2115c and Rv2116 are separated by 280 nucleotidesRv2116 and Rv2117 are separated by 7 nucleotidesRv2117 and Rv2118c are separated by 28 nucleotides Rv2115c: Rv2115c - Mycobacterial proteasome ATPase Mpa, at 2,374,461 to 2,376,290 Rv2115c Rv2116: Rv2116 - Conserved lipoprotein LppK, at 2,376,571 to 2,377,140 Rv2116 Rv2117: Rv2117 - Conserved hypothetical protein, at 2,377,148 to 2,377,441 Rv2117 Rv2118c: Rv2118c - RNA methyltransferase, at 2,377,470 to 2,378,312 Rv2118c Position (kb) 2376 2377 2378Strain fitness (log2 ratio) -2 -1 0 1 2 3at 2376.330 kb on - strandat 2376.388 kb on - strandat 2376.398 kb on - strandat 2376.398 kb on - strandat 2376.485 kb on - strandat 2376.591 kb on - strandat 2376.591 kb on - strandat 2376.881 kb on - strand, within Rv2116at 2376.881 kb on - strand, within Rv2116at 2377.039 kb on - strand, within Rv2116at 2377.072 kb on - strand, within Rv2116at 2377.439 kb on + strandat 2377.440 kb on - strandat 2377.440 kb on - strandat 2377.494 kb on - strandat 2377.494 kb on - strandat 2377.559 kb on + strand, within Rv2118cat 2377.600 kb on - strand, within Rv2118cat 2377.708 kb on + strand, within Rv2118cat 2377.709 kb on - strand, within Rv2118cat 2377.924 kb on + strand, within Rv2118cat 2378.022 kb on + strand, within Rv2118cat 2378.022 kb on + strand, within Rv2118cat 2378.023 kb on - strand, within Rv2118cat 2378.062 kb on + strand, within Rv2118cat 2378.062 kb on + strand, within Rv2118cat 2378.099 kb on - strand, within Rv2118c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with nitrite 1.5 mM; pH 5.5
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2,376,330 - -0.5
2,376,388 - +0.1
2,376,398 - -0.3
2,376,398 - -0.6
2,376,485 - -0.7
2,376,591 - -2.5
2,376,591 - -0.3
2,376,881 - Rv2116 0.54 +0.9
2,376,881 - Rv2116 0.54 -2.0
2,377,039 - Rv2116 0.82 +3.7
2,377,072 - Rv2116 0.88 -0.2
2,377,439 + -0.2
2,377,440 - -1.3
2,377,440 - +0.5
2,377,494 - +0.1
2,377,494 - -0.9
2,377,559 + Rv2118c 0.11 +0.2
2,377,600 - Rv2118c 0.15 -0.7
2,377,708 + Rv2118c 0.28 +1.1
2,377,709 - Rv2118c 0.28 -0.4
2,377,924 + Rv2118c 0.54 -0.4
2,378,022 + Rv2118c 0.65 -1.2
2,378,022 + Rv2118c 0.65 -0.6
2,378,023 - Rv2118c 0.66 -1.6
2,378,062 + Rv2118c 0.70 -0.5
2,378,062 + Rv2118c 0.70 -0.3
2,378,099 - Rv2118c 0.75 -0.1

Or see this region's nucleotide sequence