Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1835c

Experiment: 7H9 with nitrite 1.5 mM; pH 5.5

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1833c and Rv1834 are separated by 40 nucleotidesRv1834 and Rv1835c are separated by 4 nucleotidesRv1835c and Rv1836c are separated by 15 nucleotides Rv1833c: Rv1833c - Possible haloalkane dehalogenase, at 2,078,929 to 2,079,789 Rv1833c Rv1834: Rv1834 - Probable hydrolase, at 2,079,830 to 2,080,696 Rv1834 Rv1835c: Rv1835c - Conserved hypothetical protein, at 2,080,701 to 2,082,587 Rv1835c Rv1836c: Rv1836c - Conserved protein, at 2,082,603 to 2,084,636 Rv1836c Position (kb) 2080 2081 2082 2083Strain fitness (log2 ratio) -3 -2 -1 0 1 2 3at 2079.790 kb on + strandat 2080.281 kb on + strand, within Rv1834at 2080.282 kb on - strand, within Rv1834at 2080.282 kb on - strand, within Rv1834at 2080.457 kb on + strand, within Rv1834at 2080.458 kb on - strand, within Rv1834at 2080.458 kb on - strand, within Rv1834at 2080.661 kb on + strandat 2080.662 kb on - strandat 2080.710 kb on + strandat 2080.710 kb on + strandat 2080.711 kb on - strandat 2080.711 kb on - strandat 2080.753 kb on + strandat 2080.852 kb on + strandat 2080.853 kb on - strandat 2080.853 kb on - strandat 2080.902 kb on + strand, within Rv1835cat 2080.995 kb on + strand, within Rv1835cat 2080.995 kb on + strand, within Rv1835cat 2080.996 kb on - strand, within Rv1835cat 2080.996 kb on - strand, within Rv1835cat 2080.996 kb on - strand, within Rv1835cat 2081.014 kb on + strand, within Rv1835cat 2081.015 kb on - strand, within Rv1835cat 2081.015 kb on - strand, within Rv1835cat 2081.051 kb on - strand, within Rv1835cat 2081.088 kb on - strand, within Rv1835cat 2081.088 kb on - strand, within Rv1835cat 2081.147 kb on + strand, within Rv1835cat 2081.148 kb on - strand, within Rv1835cat 2081.149 kb on + strand, within Rv1835cat 2081.150 kb on - strand, within Rv1835cat 2081.150 kb on - strand, within Rv1835cat 2081.150 kb on - strand, within Rv1835cat 2081.266 kb on + strand, within Rv1835cat 2081.266 kb on + strand, within Rv1835cat 2081.266 kb on + strand, within Rv1835cat 2081.267 kb on - strand, within Rv1835cat 2081.330 kb on - strand, within Rv1835cat 2081.332 kb on + strand, within Rv1835cat 2081.332 kb on + strand, within Rv1835cat 2081.332 kb on + strand, within Rv1835cat 2081.333 kb on - strand, within Rv1835cat 2081.333 kb on - strand, within Rv1835cat 2081.333 kb on - strand, within Rv1835cat 2081.333 kb on - strand, within Rv1835cat 2081.402 kb on - strand, within Rv1835cat 2081.614 kb on + strand, within Rv1835cat 2081.615 kb on - strand, within Rv1835cat 2081.639 kb on - strand, within Rv1835cat 2081.639 kb on - strand, within Rv1835cat 2081.639 kb on - strand, within Rv1835cat 2081.680 kb on + strand, within Rv1835cat 2081.726 kb on + strand, within Rv1835cat 2081.726 kb on + strand, within Rv1835cat 2081.726 kb on + strand, within Rv1835cat 2081.765 kb on - strand, within Rv1835cat 2081.781 kb on + strand, within Rv1835cat 2081.781 kb on + strand, within Rv1835cat 2081.781 kb on + strand, within Rv1835cat 2081.828 kb on - strand, within Rv1835cat 2081.828 kb on - strand, within Rv1835cat 2081.969 kb on - strand, within Rv1835cat 2081.969 kb on - strand, within Rv1835cat 2082.031 kb on + strand, within Rv1835cat 2082.032 kb on - strand, within Rv1835cat 2082.096 kb on + strand, within Rv1835cat 2082.118 kb on + strand, within Rv1835cat 2082.311 kb on + strand, within Rv1835cat 2082.386 kb on - strand, within Rv1835cat 2082.388 kb on + strand, within Rv1835cat 2082.490 kb on + strandat 2082.490 kb on + strandat 2082.490 kb on + strandat 2082.491 kb on - strandat 2082.502 kb on + strandat 2082.502 kb on + strandat 2082.553 kb on + strandat 2082.937 kb on + strand, within Rv1836cat 2083.355 kb on - strand, within Rv1836c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with nitrite 1.5 mM; pH 5.5
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2,079,790 + -2.4
2,080,281 + Rv1834 0.52 +0.2
2,080,282 - Rv1834 0.52 -0.3
2,080,282 - Rv1834 0.52 -0.4
2,080,457 + Rv1834 0.72 -0.2
2,080,458 - Rv1834 0.72 +2.7
2,080,458 - Rv1834 0.72 +1.0
2,080,661 + -0.3
2,080,662 - -1.1
2,080,710 + -0.2
2,080,710 + -0.4
2,080,711 - +0.1
2,080,711 - -0.3
2,080,753 + +0.3
2,080,852 + -0.1
2,080,853 - -0.3
2,080,853 - +0.7
2,080,902 + Rv1835c 0.11 -0.6
2,080,995 + Rv1835c 0.16 +1.0
2,080,995 + Rv1835c 0.16 -0.4
2,080,996 - Rv1835c 0.16 +0.4
2,080,996 - Rv1835c 0.16 -0.4
2,080,996 - Rv1835c 0.16 -0.6
2,081,014 + Rv1835c 0.17 -0.1
2,081,015 - Rv1835c 0.17 +0.0
2,081,015 - Rv1835c 0.17 +0.1
2,081,051 - Rv1835c 0.19 +0.1
2,081,088 - Rv1835c 0.21 +0.1
2,081,088 - Rv1835c 0.21 +0.7
2,081,147 + Rv1835c 0.24 +0.1
2,081,148 - Rv1835c 0.24 -0.4
2,081,149 + Rv1835c 0.24 +0.8
2,081,150 - Rv1835c 0.24 -0.1
2,081,150 - Rv1835c 0.24 -0.1
2,081,150 - Rv1835c 0.24 -0.2
2,081,266 + Rv1835c 0.30 -0.6
2,081,266 + Rv1835c 0.30 -0.0
2,081,266 + Rv1835c 0.30 +0.8
2,081,267 - Rv1835c 0.30 -0.2
2,081,330 - Rv1835c 0.33 +0.3
2,081,332 + Rv1835c 0.33 -0.9
2,081,332 + Rv1835c 0.33 -0.0
2,081,332 + Rv1835c 0.33 -0.5
2,081,333 - Rv1835c 0.33 -0.0
2,081,333 - Rv1835c 0.33 +0.1
2,081,333 - Rv1835c 0.33 +0.2
2,081,333 - Rv1835c 0.33 -3.0
2,081,402 - Rv1835c 0.37 +0.3
2,081,614 + Rv1835c 0.48 +0.3
2,081,615 - Rv1835c 0.48 +1.7
2,081,639 - Rv1835c 0.50 +0.3
2,081,639 - Rv1835c 0.50 +1.7
2,081,639 - Rv1835c 0.50 -2.5
2,081,680 + Rv1835c 0.52 -1.0
2,081,726 + Rv1835c 0.54 -0.0
2,081,726 + Rv1835c 0.54 +0.6
2,081,726 + Rv1835c 0.54 -0.2
2,081,765 - Rv1835c 0.56 +0.1
2,081,781 + Rv1835c 0.57 -0.3
2,081,781 + Rv1835c 0.57 -0.9
2,081,781 + Rv1835c 0.57 -0.1
2,081,828 - Rv1835c 0.60 -0.3
2,081,828 - Rv1835c 0.60 -0.4
2,081,969 - Rv1835c 0.67 -0.3
2,081,969 - Rv1835c 0.67 -1.4
2,082,031 + Rv1835c 0.70 +0.2
2,082,032 - Rv1835c 0.71 +0.7
2,082,096 + Rv1835c 0.74 +0.0
2,082,118 + Rv1835c 0.75 -0.2
2,082,311 + Rv1835c 0.85 +0.3
2,082,386 - Rv1835c 0.89 -0.1
2,082,388 + Rv1835c 0.89 -0.7
2,082,490 + -0.3
2,082,490 + +1.0
2,082,490 + +0.1
2,082,491 - +3.7
2,082,502 + -0.4
2,082,502 + -0.6
2,082,553 + -0.6
2,082,937 + Rv1836c 0.16 +0.3
2,083,355 - Rv1836c 0.37 +0.1

Or see this region's nucleotide sequence