Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0192

Experiment: 7H9 with nitrite 3 mM; pH 5.5

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0191 and Rv0192 are separated by 33 nucleotidesRv0192 and Rv0192A overlap by 1058 nucleotidesRv0192A and Rv0193c are separated by 814 nucleotides Rv0191: Rv0191 - Probable conserved integral membrane protein, at 222,289 to 223,530 Rv0191 Rv0192: Rv0192 - Conserved hypothetical protein, at 223,564 to 224,664 Rv0192 Rv0192A: Rv0192A - Conserved secreted protein, at 223,607 to 223,909 Rv0192A Rv0193c: Rv0193c - Hypothetical protein, at 224,724 to 226,571 Rv0193c Position (kb) 223 224 225Strain fitness (log2 ratio) -2 -1 0 1 2at 222.739 kb on + strand, within Rv0191at 222.740 kb on - strand, within Rv0191at 222.740 kb on - strand, within Rv0191at 222.940 kb on - strand, within Rv0191at 223.003 kb on + strand, within Rv0191at 223.003 kb on + strand, within Rv0191at 223.003 kb on + strand, within Rv0191at 223.003 kb on + strand, within Rv0191at 223.003 kb on + strand, within Rv0191at 223.003 kb on + strand, within Rv0191at 223.004 kb on - strand, within Rv0191at 223.004 kb on - strand, within Rv0191at 223.009 kb on + strand, within Rv0191at 223.010 kb on - strand, within Rv0191at 223.043 kb on + strand, within Rv0191at 223.043 kb on + strand, within Rv0191at 223.044 kb on - strand, within Rv0191at 223.044 kb on - strand, within Rv0191at 223.044 kb on - strand, within Rv0191at 223.078 kb on + strand, within Rv0191at 223.158 kb on + strand, within Rv0191at 223.315 kb on - strand, within Rv0191at 223.351 kb on + strand, within Rv0191at 223.351 kb on + strand, within Rv0191at 223.352 kb on - strand, within Rv0191at 223.352 kb on - strand, within Rv0191at 223.352 kb on - strand, within Rv0191at 223.352 kb on - strand, within Rv0191at 223.409 kb on - strandat 223.409 kb on - strandat 223.563 kb on + strandat 223.607 kb on - strandat 223.607 kb on - strandat 223.607 kb on - strandat 223.607 kb on - strandat 223.645 kb on - strandat 223.663 kb on - strandat 223.907 kb on + strandat 224.114 kb on - strandat 224.350 kb on + strandat 224.350 kb on + strandat 224.351 kb on - strandat 224.351 kb on - strandat 224.351 kb on - strandat 224.353 kb on + strandat 224.354 kb on - strandat 224.354 kb on - strandat 224.354 kb on - strandat 224.354 kb on - strandat 224.354 kb on - strandat 224.398 kb on + strandat 224.399 kb on - strandat 224.399 kb on - strandat 224.399 kb on - strandat 224.428 kb on + strandat 224.429 kb on - strandat 224.572 kb on + strandat 224.572 kb on + strandat 224.626 kb on + strandat 224.627 kb on - strandat 224.663 kb on - strandat 224.715 kb on - strandat 224.725 kb on + strandat 224.756 kb on - strandat 224.756 kb on - strandat 224.819 kb on - strandat 224.864 kb on - strandat 224.864 kb on - strandat 224.864 kb on - strandat 224.864 kb on - strandat 224.864 kb on - strandat 225.016 kb on - strand, within Rv0193cat 225.030 kb on + strand, within Rv0193cat 225.055 kb on - strand, within Rv0193cat 225.055 kb on - strand, within Rv0193cat 225.055 kb on - strand, within Rv0193cat 225.112 kb on + strand, within Rv0193cat 225.112 kb on + strand, within Rv0193cat 225.112 kb on + strand, within Rv0193cat 225.113 kb on - strand, within Rv0193cat 225.113 kb on - strand, within Rv0193cat 225.113 kb on - strand, within Rv0193cat 225.113 kb on - strand, within Rv0193cat 225.113 kb on - strand, within Rv0193cat 225.185 kb on - strand, within Rv0193cat 225.185 kb on - strand, within Rv0193cat 225.467 kb on + strand, within Rv0193cat 225.482 kb on - strand, within Rv0193cat 225.503 kb on + strand, within Rv0193cat 225.503 kb on + strand, within Rv0193cat 225.504 kb on - strand, within Rv0193cat 225.504 kb on - strand, within Rv0193cat 225.663 kb on + strand, within Rv0193cat 225.664 kb on - strand, within Rv0193cat 225.664 kb on - strand, within Rv0193c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with nitrite 3 mM; pH 5.5
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222,739 + Rv0191 0.36 -0.3
222,740 - Rv0191 0.36 +0.1
222,740 - Rv0191 0.36 +0.1
222,940 - Rv0191 0.52 -0.3
223,003 + Rv0191 0.57 -1.2
223,003 + Rv0191 0.57 -1.8
223,003 + Rv0191 0.57 -0.5
223,003 + Rv0191 0.57 +0.1
223,003 + Rv0191 0.57 -0.2
223,003 + Rv0191 0.57 -1.0
223,004 - Rv0191 0.58 -0.6
223,004 - Rv0191 0.58 -0.6
223,009 + Rv0191 0.58 +0.2
223,010 - Rv0191 0.58 -1.0
223,043 + Rv0191 0.61 -1.8
223,043 + Rv0191 0.61 -0.4
223,044 - Rv0191 0.61 -0.3
223,044 - Rv0191 0.61 -0.2
223,044 - Rv0191 0.61 -0.3
223,078 + Rv0191 0.64 +0.7
223,158 + Rv0191 0.70 -1.9
223,315 - Rv0191 0.83 -0.4
223,351 + Rv0191 0.86 -0.1
223,351 + Rv0191 0.86 -0.3
223,352 - Rv0191 0.86 -0.9
223,352 - Rv0191 0.86 -0.6
223,352 - Rv0191 0.86 -1.8
223,352 - Rv0191 0.86 -0.1
223,409 - +0.2
223,409 - +0.4
223,563 + -0.1
223,607 - +0.0
223,607 - +0.3
223,607 - -1.9
223,607 - -1.0
223,645 - +0.1
223,663 - -2.2
223,907 + -0.2
224,114 - +0.7
224,350 + -0.8
224,350 + -0.3
224,351 - -0.4
224,351 - +0.6
224,351 - -0.3
224,353 + -0.4
224,354 - -0.7
224,354 - -0.1
224,354 - +1.0
224,354 - -0.0
224,354 - +0.1
224,398 + -0.2
224,399 - -2.0
224,399 - +0.1
224,399 - -0.1
224,428 + +0.3
224,429 - -1.1
224,572 + +0.4
224,572 + -0.6
224,626 + -1.5
224,627 - +2.2
224,663 - -0.1
224,715 - -0.5
224,725 + -0.8
224,756 - +0.0
224,756 - -0.3
224,819 - -0.3
224,864 - +0.4
224,864 - -1.0
224,864 - -0.5
224,864 - -1.0
224,864 - +0.2
225,016 - Rv0193c 0.16 +0.6
225,030 + Rv0193c 0.17 -0.4
225,055 - Rv0193c 0.18 +1.6
225,055 - Rv0193c 0.18 -1.6
225,055 - Rv0193c 0.18 -1.9
225,112 + Rv0193c 0.21 -1.0
225,112 + Rv0193c 0.21 -0.8
225,112 + Rv0193c 0.21 -1.4
225,113 - Rv0193c 0.21 -2.1
225,113 - Rv0193c 0.21 -1.7
225,113 - Rv0193c 0.21 -0.0
225,113 - Rv0193c 0.21 -0.7
225,113 - Rv0193c 0.21 -0.3
225,185 - Rv0193c 0.25 -0.3
225,185 - Rv0193c 0.25 -1.2
225,467 + Rv0193c 0.40 +0.2
225,482 - Rv0193c 0.41 +0.3
225,503 + Rv0193c 0.42 -0.4
225,503 + Rv0193c 0.42 -1.0
225,504 - Rv0193c 0.42 +0.7
225,504 - Rv0193c 0.42 -2.1
225,663 + Rv0193c 0.51 -0.3
225,664 - Rv0193c 0.51 -0.2
225,664 - Rv0193c 0.51 -0.4

Or see this region's nucleotide sequence