Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0586

Experiment: 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0585c and Rv0586 are separated by 137 nucleotidesRv0586 and Rv0587 overlap by 4 nucleotidesRv0587 and Rv0588 are separated by 1 nucleotides Rv0585c: Rv0585c - Probable conserved integral membrane protein, at 681,885 to 684,272 Rv0585c Rv0586: Rv0586 - Probable transcriptional regulatory protein Mce2R (GntR-family), at 684,410 to 685,132 Rv0586 Rv0587: Rv0587 - Conserved hypothetical integral membrane protein YrbE2A, at 685,129 to 685,926 Rv0587 Rv0588: Rv0588 - Conserved hypothetical integral membrane protein YrbE2B, at 685,928 to 686,815 Rv0588 Position (kb) 684 685 686Strain fitness (log2 ratio) -2 -1 0 1at 683.952 kb on - strand, within Rv0585cat 684.058 kb on + strandat 684.059 kb on - strandat 684.278 kb on - strandat 684.278 kb on - strandat 684.339 kb on + strandat 684.700 kb on + strand, within Rv0586at 685.157 kb on - strandat 685.217 kb on + strand, within Rv0587at 685.218 kb on - strand, within Rv0587at 685.359 kb on + strand, within Rv0587

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5
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683,952 - Rv0585c 0.87 -1.8
684,058 + +1.4
684,059 - -1.4
684,278 - +1.7
684,278 - -0.0
684,339 + +0.0
684,700 + Rv0586 0.40 -0.7
685,157 - -0.0
685,217 + Rv0587 0.11 -2.6
685,218 - Rv0587 0.11 +1.0
685,359 + Rv0587 0.29 -0.4

Or see this region's nucleotide sequence