Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0402c

Experiment: 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0400c and Rv0401 are separated by 35 nucleotidesRv0401 and Rv0402c are separated by 194 nucleotidesRv0402c and Rv0403c overlap by 4 nucleotidesRv0403c and Rv0404 are separated by 320 nucleotides Rv0400c: Rv0400c - Acyl-CoA dehydrogenase FadE7, at 478,566 to 479,753 Rv0400c Rv0401: Rv0401 - Probable conserved transmembrane protein, at 479,789 to 480,160 Rv0401 Rv0402c: Rv0402c - Probable conserved transmembrane transport protein MmpL1, at 480,355 to 483,231 Rv0402c Rv0403c: Rv0403c - Probable conserved membrane protein MmpS1, at 483,228 to 483,656 Rv0403c Rv0404: Rv0404 - Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase), at 483,977 to 485,734 Rv0404 Position (kb) 480 481 482 483 484Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 479.497 kb on + strand, within Rv0400cat 479.498 kb on - strand, within Rv0400cat 479.498 kb on - strand, within Rv0400cat 479.498 kb on - strand, within Rv0400cat 479.761 kb on + strandat 480.314 kb on + strandat 480.336 kb on + strandat 480.498 kb on - strandat 480.704 kb on - strand, within Rv0402cat 480.783 kb on + strand, within Rv0402cat 480.783 kb on + strand, within Rv0402cat 480.947 kb on + strand, within Rv0402cat 480.947 kb on + strand, within Rv0402cat 480.947 kb on + strand, within Rv0402cat 480.948 kb on - strand, within Rv0402cat 480.948 kb on - strand, within Rv0402cat 480.975 kb on - strand, within Rv0402cat 480.998 kb on + strand, within Rv0402cat 481.367 kb on - strand, within Rv0402cat 481.512 kb on - strand, within Rv0402cat 481.600 kb on - strand, within Rv0402cat 481.611 kb on + strand, within Rv0402cat 481.611 kb on + strand, within Rv0402cat 481.611 kb on + strand, within Rv0402cat 481.612 kb on - strand, within Rv0402cat 481.612 kb on - strand, within Rv0402cat 481.612 kb on - strand, within Rv0402cat 482.009 kb on + strand, within Rv0402cat 482.009 kb on + strand, within Rv0402cat 482.010 kb on - strand, within Rv0402cat 482.010 kb on - strand, within Rv0402cat 482.013 kb on - strand, within Rv0402cat 482.013 kb on - strand, within Rv0402cat 482.024 kb on + strand, within Rv0402cat 482.025 kb on - strand, within Rv0402cat 482.036 kb on + strand, within Rv0402cat 482.036 kb on + strand, within Rv0402cat 482.069 kb on - strand, within Rv0402cat 482.301 kb on - strand, within Rv0402cat 482.366 kb on + strand, within Rv0402cat 482.436 kb on - strand, within Rv0402cat 482.487 kb on + strand, within Rv0402cat 482.488 kb on - strand, within Rv0402cat 482.597 kb on + strand, within Rv0402cat 482.671 kb on + strand, within Rv0402cat 482.672 kb on - strand, within Rv0402cat 482.711 kb on + strand, within Rv0402cat 482.711 kb on + strand, within Rv0402cat 482.822 kb on + strand, within Rv0402cat 482.823 kb on - strand, within Rv0402cat 482.823 kb on - strand, within Rv0402cat 482.939 kb on + strand, within Rv0402cat 483.073 kb on + strandat 483.135 kb on + strandat 483.387 kb on - strand, within Rv0403cat 483.387 kb on - strand, within Rv0403cat 483.446 kb on - strand, within Rv0403cat 483.488 kb on - strand, within Rv0403cat 483.615 kb on + strandat 483.615 kb on + strandat 483.616 kb on - strandat 483.616 kb on - strandat 483.616 kb on - strandat 483.815 kb on + strandat 483.987 kb on + strandat 484.199 kb on + strand, within Rv0404at 484.199 kb on + strand, within Rv0404

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5
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479,497 + Rv0400c 0.78 -1.5
479,498 - Rv0400c 0.78 -0.7
479,498 - Rv0400c 0.78 -0.7
479,498 - Rv0400c 0.78 -0.6
479,761 + -0.8
480,314 + -0.2
480,336 + +1.7
480,498 - -2.6
480,704 - Rv0402c 0.12 -1.0
480,783 + Rv0402c 0.15 -0.5
480,783 + Rv0402c 0.15 -0.4
480,947 + Rv0402c 0.21 +2.5
480,947 + Rv0402c 0.21 +0.2
480,947 + Rv0402c 0.21 -0.8
480,948 - Rv0402c 0.21 -0.3
480,948 - Rv0402c 0.21 +0.0
480,975 - Rv0402c 0.22 -0.3
480,998 + Rv0402c 0.22 -0.0
481,367 - Rv0402c 0.35 -0.6
481,512 - Rv0402c 0.40 -0.9
481,600 - Rv0402c 0.43 +1.8
481,611 + Rv0402c 0.44 +0.9
481,611 + Rv0402c 0.44 +1.1
481,611 + Rv0402c 0.44 -0.0
481,612 - Rv0402c 0.44 +0.4
481,612 - Rv0402c 0.44 +0.1
481,612 - Rv0402c 0.44 +1.5
482,009 + Rv0402c 0.57 +0.2
482,009 + Rv0402c 0.57 -2.8
482,010 - Rv0402c 0.58 -1.3
482,010 - Rv0402c 0.58 +0.0
482,013 - Rv0402c 0.58 -0.2
482,013 - Rv0402c 0.58 -0.3
482,024 + Rv0402c 0.58 +0.8
482,025 - Rv0402c 0.58 -0.3
482,036 + Rv0402c 0.58 +2.1
482,036 + Rv0402c 0.58 +0.5
482,069 - Rv0402c 0.60 +2.4
482,301 - Rv0402c 0.68 -0.4
482,366 + Rv0402c 0.70 -0.2
482,436 - Rv0402c 0.72 -0.2
482,487 + Rv0402c 0.74 +0.3
482,488 - Rv0402c 0.74 -0.9
482,597 + Rv0402c 0.78 +0.7
482,671 + Rv0402c 0.81 +0.0
482,672 - Rv0402c 0.81 -0.5
482,711 + Rv0402c 0.82 -1.1
482,711 + Rv0402c 0.82 +0.1
482,822 + Rv0402c 0.86 -0.3
482,823 - Rv0402c 0.86 -0.3
482,823 - Rv0402c 0.86 -0.3
482,939 + Rv0402c 0.90 -0.6
483,073 + -0.9
483,135 + +0.6
483,387 - Rv0403c 0.37 -0.3
483,387 - Rv0403c 0.37 -0.1
483,446 - Rv0403c 0.51 +0.0
483,488 - Rv0403c 0.61 -0.5
483,615 + -0.1
483,615 + -0.5
483,616 - -2.2
483,616 - -0.2
483,616 - -0.6
483,815 + -1.7
483,987 + +0.1
484,199 + Rv0404 0.13 +0.8
484,199 + Rv0404 0.13 +0.1

Or see this region's nucleotide sequence