Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1389

Experiment: pH 4.5

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1388 and Rv1389 are separated by 134 nucleotidesRv1389 and Rv1390 are separated by 65 nucleotidesRv1390 and Rv1391 are separated by 15 nucleotides Rv1388: Rv1388 - Putative integration host factor MihF, at 1,563,694 to 1,564,266 Rv1388 Rv1389: Rv1389 - Probable guanylate kinase Gmk, at 1,564,401 to 1,565,027 Rv1389 Rv1390: Rv1390 - Probable DNA-directed RNA polymerase (omega chain) RpoZ (transcriptase omega chain) (RNA polymerase omega subunit), at 1,565,093 to 1,565,425 Rv1390 Rv1391: Rv1391 - Probable DNA/pantothenate metabolism flavoprotein homolog Dfp, at 1,565,441 to 1,566,697 Rv1391 Position (kb) 1564 1565 1566Strain fitness (log2 ratio) -1 0 1at 1563.438 kb on + strandat 1563.438 kb on + strandat 1563.439 kb on - strandat 1563.487 kb on + strandat 1563.488 kb on - strandat 1563.488 kb on - strandat 1565.041 kb on + strandat 1565.048 kb on + strandat 1565.048 kb on + strandat 1565.048 kb on + strandat 1565.052 kb on + strandat 1565.052 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction pH 4.5
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1,563,438 + -1.6
1,563,438 + +0.7
1,563,439 - +1.7
1,563,487 + +1.7
1,563,488 - +0.2
1,563,488 - -0.3
1,565,041 + +0.0
1,565,048 + -0.3
1,565,048 + -0.8
1,565,048 + -0.2
1,565,052 + -1.7
1,565,052 + +0.3

Or see this region's nucleotide sequence