Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2045c

Experiment: pH 4.5

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2043c and Rv2044c are separated by 40 nucleotidesRv2044c and Rv2045c are separated by 85 nucleotidesRv2045c and Rv2046 are separated by 48 nucleotidesRv2046 and Rv2047c are separated by 36 nucleotides Rv2043c: Rv2043c - Pyrazinamidase/nicotinamidase PncA (PZase), at 2,288,681 to 2,289,241 Rv2043c Rv2044c: Rv2044c - Conserved hypothetical protein, at 2,289,282 to 2,289,599 Rv2044c Rv2045c: Rv2045c - Carboxylesterase LipT, at 2,289,685 to 2,291,220 Rv2045c Rv2046: Rv2046 - Probable lipoprotein LppI, at 2,291,269 to 2,291,925 Rv2046 Rv2047c: Rv2047c - Conserved hypothetical protein, at 2,291,962 to 2,294,526 Rv2047c Position (kb) 2289 2290 2291 2292Strain fitness (log2 ratio) -1 0 1 2 3at 2288.846 kb on - strand, within Rv2043cat 2288.958 kb on + strand, within Rv2043cat 2289.141 kb on + strand, within Rv2043cat 2289.241 kb on + strandat 2289.241 kb on + strandat 2289.242 kb on - strandat 2289.252 kb on + strandat 2289.253 kb on - strandat 2289.306 kb on + strandat 2289.307 kb on - strandat 2289.391 kb on + strand, within Rv2044cat 2289.578 kb on - strandat 2289.612 kb on + strandat 2289.794 kb on + strandat 2289.926 kb on + strand, within Rv2045cat 2290.007 kb on + strand, within Rv2045cat 2290.013 kb on + strand, within Rv2045cat 2290.019 kb on + strand, within Rv2045cat 2290.020 kb on - strand, within Rv2045cat 2290.020 kb on - strand, within Rv2045cat 2290.175 kb on - strand, within Rv2045cat 2290.319 kb on + strand, within Rv2045cat 2290.556 kb on - strand, within Rv2045cat 2290.793 kb on + strand, within Rv2045cat 2290.793 kb on + strand, within Rv2045cat 2290.829 kb on + strand, within Rv2045cat 2290.830 kb on - strand, within Rv2045cat 2290.886 kb on - strand, within Rv2045cat 2291.100 kb on - strandat 2291.190 kb on + strandat 2291.191 kb on - strandat 2291.340 kb on - strand, within Rv2046at 2291.557 kb on - strand, within Rv2046at 2291.726 kb on - strand, within Rv2046at 2291.818 kb on + strand, within Rv2046at 2291.957 kb on + strandat 2291.957 kb on + strandat 2291.957 kb on + strandat 2291.958 kb on - strandat 2292.082 kb on - strandat 2292.082 kb on - strandat 2292.183 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction pH 4.5
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2,288,846 - Rv2043c 0.29 -1.7
2,288,958 + Rv2043c 0.49 -0.7
2,289,141 + Rv2043c 0.82 -0.9
2,289,241 + -0.7
2,289,241 + -0.4
2,289,242 - -0.5
2,289,252 + -0.2
2,289,253 - -0.6
2,289,306 + -1.5
2,289,307 - +1.8
2,289,391 + Rv2044c 0.34 +0.1
2,289,578 - +2.1
2,289,612 + -1.4
2,289,794 + -1.1
2,289,926 + Rv2045c 0.16 -1.0
2,290,007 + Rv2045c 0.21 +1.2
2,290,013 + Rv2045c 0.21 -1.4
2,290,019 + Rv2045c 0.22 -0.8
2,290,020 - Rv2045c 0.22 -0.0
2,290,020 - Rv2045c 0.22 -1.4
2,290,175 - Rv2045c 0.32 -1.4
2,290,319 + Rv2045c 0.41 -0.9
2,290,556 - Rv2045c 0.57 +0.3
2,290,793 + Rv2045c 0.72 -0.6
2,290,793 + Rv2045c 0.72 -1.5
2,290,829 + Rv2045c 0.74 -0.4
2,290,830 - Rv2045c 0.75 -0.6
2,290,886 - Rv2045c 0.78 -1.1
2,291,100 - +3.4
2,291,190 + -0.5
2,291,191 - -0.3
2,291,340 - Rv2046 0.11 -0.8
2,291,557 - Rv2046 0.44 -0.6
2,291,726 - Rv2046 0.70 -0.7
2,291,818 + Rv2046 0.84 +0.6
2,291,957 + -0.3
2,291,957 + +1.2
2,291,957 + +0.5
2,291,958 - +0.0
2,292,082 - -0.2
2,292,082 - -0.3
2,292,183 - -1.3

Or see this region's nucleotide sequence