Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1136

Experiment: pH 4.5

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1135c and Rv1135A are separated by 185 nucleotidesRv1135A and Rv1136 are separated by 49 nucleotidesRv1136 and Rv1137c are separated by 139 nucleotidesRv1137c and Rv1138c are separated by 16 nucleotides Rv1135c: Rv1135c - PPE family protein PPE16, at 1,262,272 to 1,264,128 Rv1135c Rv1135A: Rv1135A - Possible acetyl-CoA acetyltransferase (acetoacetyl-CoA thiolase), at 1,264,314 to 1,264,556 Rv1135A Rv1136: Rv1136 - Possible enoyl-CoA hydratase, at 1,264,606 to 1,264,947 Rv1136 Rv1137c: Rv1137c - Hypothetical protein, at 1,265,087 to 1,265,455 Rv1137c Rv1138c: Rv1138c - Possible oxidoreductase, at 1,265,472 to 1,266,488 Rv1138c Position (kb) 1264 1265Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 1263.668 kb on + strand, within Rv1135cat 1263.669 kb on - strand, within Rv1135cat 1263.711 kb on - strand, within Rv1135cat 1263.711 kb on - strand, within Rv1135cat 1263.711 kb on - strand, within Rv1135cat 1263.764 kb on - strand, within Rv1135cat 1263.839 kb on + strand, within Rv1135cat 1263.914 kb on + strand, within Rv1135cat 1264.015 kb on + strandat 1264.337 kb on + strandat 1264.380 kb on + strand, within Rv1135Aat 1264.462 kb on + strand, within Rv1135Aat 1264.615 kb on - strandat 1264.615 kb on - strandat 1264.998 kb on + strandat 1265.315 kb on - strand, within Rv1137cat 1265.357 kb on + strand, within Rv1137cat 1265.358 kb on - strand, within Rv1137cat 1265.920 kb on + strand, within Rv1138cat 1265.920 kb on + strand, within Rv1138cat 1265.921 kb on - strand, within Rv1138cat 1265.921 kb on - strand, within Rv1138c

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Per-strain Table

Position Strand Gene LocusTag Fraction pH 4.5
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1,263,668 + Rv1135c 0.75 +0.4
1,263,669 - Rv1135c 0.75 -0.5
1,263,711 - Rv1135c 0.77 -0.6
1,263,711 - Rv1135c 0.77 +0.7
1,263,711 - Rv1135c 0.77 -0.3
1,263,764 - Rv1135c 0.80 -0.0
1,263,839 + Rv1135c 0.84 -0.8
1,263,914 + Rv1135c 0.88 +0.5
1,264,015 + +0.2
1,264,337 + -0.8
1,264,380 + Rv1135A 0.27 -0.8
1,264,462 + Rv1135A 0.61 +1.8
1,264,615 - -0.6
1,264,615 - +1.1
1,264,998 + -0.2
1,265,315 - Rv1137c 0.62 -0.2
1,265,357 + Rv1137c 0.73 -0.8
1,265,358 - Rv1137c 0.73 -3.0
1,265,920 + Rv1138c 0.44 +0.3
1,265,920 + Rv1138c 0.44 -0.2
1,265,921 - Rv1138c 0.44 -0.0
1,265,921 - Rv1138c 0.44 +0.2

Or see this region's nucleotide sequence