Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3750c

Experiment: 7H9 with hypochlorite 0.4 vol%

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3748 and Rv3749c are separated by 32 nucleotidesRv3749c and Rv3750c are separated by 67 nucleotidesRv3750c and Rv3751 are separated by 276 nucleotidesRv3751 and GFF3901 are separated by 41 nucleotidesGFF3901 and Rv3752c are separated by 29 nucleotides Rv3748: Rv3748 - Conserved hypothetical protein, at 4,197,236 to 4,197,595 Rv3748 Rv3749c: Rv3749c - Conserved hypothetical protein, at 4,197,628 to 4,198,137 Rv3749c Rv3750c: Rv3750c - Possible excisionase, at 4,198,205 to 4,198,597 Rv3750c Rv3751: Rv3751 - Probable integrase (fragment), at 4,198,874 to 4,199,089 Rv3751 GFF3901 - tRNA-Ser, at 4,199,131 to 4,199,217 GFF3901 Rv3752c: Rv3752c - Possible cytidine/deoxycytidylate deaminase, at 4,199,247 to 4,199,705 Rv3752c Position (kb) 4198 4199Strain fitness (log2 ratio) -2 -1 0 1 2 3at 4197.241 kb on - strandat 4197.510 kb on + strand, within Rv3748at 4197.600 kb on + strandat 4197.600 kb on + strandat 4197.601 kb on - strandat 4197.601 kb on - strandat 4197.601 kb on - strandat 4197.630 kb on - strandat 4197.630 kb on - strandat 4197.630 kb on - strandat 4197.734 kb on - strand, within Rv3749cat 4197.734 kb on - strand, within Rv3749cat 4197.734 kb on - strand, within Rv3749cat 4197.767 kb on + strand, within Rv3749cat 4197.798 kb on + strand, within Rv3749cat 4197.813 kb on - strand, within Rv3749cat 4197.866 kb on + strand, within Rv3749cat 4197.867 kb on - strand, within Rv3749cat 4197.867 kb on - strand, within Rv3749cat 4197.875 kb on - strand, within Rv3749cat 4197.913 kb on + strand, within Rv3749cat 4197.913 kb on + strand, within Rv3749cat 4197.947 kb on - strand, within Rv3749cat 4197.965 kb on + strand, within Rv3749cat 4197.965 kb on + strand, within Rv3749cat 4197.965 kb on + strand, within Rv3749cat 4197.965 kb on + strand, within Rv3749cat 4197.965 kb on + strand, within Rv3749cat 4197.966 kb on - strand, within Rv3749cat 4197.966 kb on - strand, within Rv3749cat 4197.966 kb on - strand, within Rv3749cat 4198.104 kb on + strandat 4198.104 kb on + strandat 4198.105 kb on - strandat 4198.179 kb on - strandat 4198.179 kb on - strandat 4198.207 kb on - strandat 4198.266 kb on - strand, within Rv3750cat 4198.433 kb on + strand, within Rv3750cat 4198.497 kb on + strand, within Rv3750cat 4198.497 kb on + strand, within Rv3750cat 4198.498 kb on - strand, within Rv3750cat 4198.498 kb on - strand, within Rv3750cat 4198.623 kb on + strandat 4198.623 kb on + strandat 4198.624 kb on - strandat 4198.624 kb on - strandat 4198.664 kb on + strandat 4198.665 kb on - strandat 4198.707 kb on - strandat 4198.715 kb on + strandat 4198.716 kb on - strandat 4198.850 kb on - strandat 4199.016 kb on - strand, within Rv3751at 4199.016 kb on - strand, within Rv3751

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with hypochlorite 0.4 vol%
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4,197,241 - -1.0
4,197,510 + Rv3748 0.76 -0.5
4,197,600 + -0.4
4,197,600 + +1.0
4,197,601 - -1.0
4,197,601 - -1.8
4,197,601 - +0.0
4,197,630 - -0.2
4,197,630 - -0.3
4,197,630 - -0.4
4,197,734 - Rv3749c 0.21 -0.7
4,197,734 - Rv3749c 0.21 -0.9
4,197,734 - Rv3749c 0.21 +0.1
4,197,767 + Rv3749c 0.27 -0.4
4,197,798 + Rv3749c 0.33 -0.6
4,197,813 - Rv3749c 0.36 -2.1
4,197,866 + Rv3749c 0.47 -0.3
4,197,867 - Rv3749c 0.47 +1.2
4,197,867 - Rv3749c 0.47 -0.1
4,197,875 - Rv3749c 0.48 +0.6
4,197,913 + Rv3749c 0.56 +1.1
4,197,913 + Rv3749c 0.56 +0.0
4,197,947 - Rv3749c 0.63 +0.1
4,197,965 + Rv3749c 0.66 -0.7
4,197,965 + Rv3749c 0.66 -0.4
4,197,965 + Rv3749c 0.66 +1.5
4,197,965 + Rv3749c 0.66 +0.4
4,197,965 + Rv3749c 0.66 -0.0
4,197,966 - Rv3749c 0.66 +2.8
4,197,966 - Rv3749c 0.66 +0.8
4,197,966 - Rv3749c 0.66 -0.5
4,198,104 + -0.6
4,198,104 + -0.8
4,198,105 - -0.3
4,198,179 - -1.7
4,198,179 - -0.5
4,198,207 - +0.4
4,198,266 - Rv3750c 0.16 -0.3
4,198,433 + Rv3750c 0.58 +1.0
4,198,497 + Rv3750c 0.74 -0.3
4,198,497 + Rv3750c 0.74 -0.2
4,198,498 - Rv3750c 0.75 +1.6
4,198,498 - Rv3750c 0.75 +1.0
4,198,623 + +0.6
4,198,623 + -0.5
4,198,624 - -1.1
4,198,624 - -0.8
4,198,664 + -0.4
4,198,665 - +1.8
4,198,707 - -0.1
4,198,715 + -0.5
4,198,716 - -0.2
4,198,850 - -0.5
4,199,016 - Rv3751 0.66 +0.5
4,199,016 - Rv3751 0.66 +0.4

Or see this region's nucleotide sequence