Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0145

Experiment: 7H9 with hypochlorite 0.4 vol%

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0144 and Rv0145 are separated by 88 nucleotidesRv0145 and Rv0146 are separated by 42 nucleotides Rv0144: Rv0144 - Probable transcriptional regulatory protein (possibly TetR-family), at 170,284 to 171,126 Rv0144 Rv0145: Rv0145 - Possible S-adenosylmethionine-dependent methyltransferase, at 171,215 to 172,168 Rv0145 Rv0146: Rv0146 - Possible S-adenosylmethionine-dependent methyltransferase, at 172,211 to 173,143 Rv0146 Position (kb) 171 172 173Strain fitness (log2 ratio) -2 -1 0 1 2at 170.244 kb on - strandat 170.432 kb on + strand, within Rv0144at 170.432 kb on + strand, within Rv0144at 170.432 kb on + strand, within Rv0144at 170.450 kb on + strand, within Rv0144at 170.450 kb on + strand, within Rv0144at 170.451 kb on - strand, within Rv0144at 170.451 kb on - strand, within Rv0144at 170.454 kb on + strand, within Rv0144at 170.454 kb on + strand, within Rv0144at 170.480 kb on + strand, within Rv0144at 170.480 kb on + strand, within Rv0144at 170.481 kb on - strand, within Rv0144at 170.481 kb on - strand, within Rv0144at 170.559 kb on + strand, within Rv0144at 170.560 kb on - strand, within Rv0144at 170.560 kb on - strand, within Rv0144at 170.665 kb on + strand, within Rv0144at 170.665 kb on + strand, within Rv0144at 170.666 kb on - strand, within Rv0144at 170.689 kb on + strand, within Rv0144at 170.689 kb on + strand, within Rv0144at 170.689 kb on + strand, within Rv0144at 170.689 kb on + strand, within Rv0144at 171.031 kb on + strand, within Rv0144at 171.031 kb on + strand, within Rv0144at 171.032 kb on - strand, within Rv0144at 171.032 kb on - strand, within Rv0144at 171.032 kb on - strand, within Rv0144at 171.032 kb on - strand, within Rv0144at 171.033 kb on + strand, within Rv0144at 171.052 kb on + strandat 171.052 kb on + strandat 171.052 kb on + strandat 171.201 kb on + strandat 171.202 kb on - strandat 171.202 kb on - strandat 171.489 kb on - strand, within Rv0145at 171.521 kb on + strand, within Rv0145at 171.657 kb on - strand, within Rv0145at 171.657 kb on - strand, within Rv0145at 171.753 kb on + strand, within Rv0145at 171.753 kb on + strand, within Rv0145at 171.808 kb on - strand, within Rv0145at 171.958 kb on - strand, within Rv0145at 171.984 kb on - strand, within Rv0145at 172.399 kb on - strand, within Rv0146at 172.487 kb on - strand, within Rv0146at 172.487 kb on - strand, within Rv0146at 172.490 kb on + strand, within Rv0146at 172.490 kb on + strand, within Rv0146at 172.491 kb on - strand, within Rv0146at 172.527 kb on + strand, within Rv0146at 172.595 kb on + strand, within Rv0146at 172.596 kb on - strand, within Rv0146at 172.625 kb on + strand, within Rv0146at 172.625 kb on + strand, within Rv0146at 172.625 kb on + strand, within Rv0146at 172.625 kb on + strand, within Rv0146at 172.626 kb on - strand, within Rv0146at 172.626 kb on - strand, within Rv0146at 172.781 kb on + strand, within Rv0146at 172.781 kb on + strand, within Rv0146at 172.781 kb on + strand, within Rv0146at 172.782 kb on - strand, within Rv0146at 172.782 kb on - strand, within Rv0146at 172.782 kb on - strand, within Rv0146at 172.784 kb on - strand, within Rv0146at 172.785 kb on + strand, within Rv0146at 172.970 kb on + strand, within Rv0146at 172.971 kb on - strand, within Rv0146at 172.971 kb on - strand, within Rv0146at 173.141 kb on + strandat 173.141 kb on + strandat 173.142 kb on - strandat 173.164 kb on + strandat 173.164 kb on + strandat 173.164 kb on + strandat 173.164 kb on + strandat 173.164 kb on + strandat 173.164 kb on + strandat 173.164 kb on + strandat 173.164 kb on + strandat 173.164 kb on + strandat 173.164 kb on + strandat 173.165 kb on - strandat 173.165 kb on - strandat 173.165 kb on - strandat 173.165 kb on - strandat 173.165 kb on - strandat 173.165 kb on - strandat 173.165 kb on - strandat 173.165 kb on - strandat 173.166 kb on + strandat 173.166 kb on + strandat 173.167 kb on - strandat 173.167 kb on - strandat 173.167 kb on - strandat 173.168 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with hypochlorite 0.4 vol%
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170,244 - -0.4
170,432 + Rv0144 0.18 -1.3
170,432 + Rv0144 0.18 -2.1
170,432 + Rv0144 0.18 +0.1
170,450 + Rv0144 0.20 -0.7
170,450 + Rv0144 0.20 -0.3
170,451 - Rv0144 0.20 -1.4
170,451 - Rv0144 0.20 -2.1
170,454 + Rv0144 0.20 +0.7
170,454 + Rv0144 0.20 +0.3
170,480 + Rv0144 0.23 +0.1
170,480 + Rv0144 0.23 -0.5
170,481 - Rv0144 0.23 -0.6
170,481 - Rv0144 0.23 -0.1
170,559 + Rv0144 0.33 +1.4
170,560 - Rv0144 0.33 +1.0
170,560 - Rv0144 0.33 +0.1
170,665 + Rv0144 0.45 +0.1
170,665 + Rv0144 0.45 +0.4
170,666 - Rv0144 0.45 -0.0
170,689 + Rv0144 0.48 -0.3
170,689 + Rv0144 0.48 -0.7
170,689 + Rv0144 0.48 -0.0
170,689 + Rv0144 0.48 +0.1
171,031 + Rv0144 0.89 -0.7
171,031 + Rv0144 0.89 +0.8
171,032 - Rv0144 0.89 -0.3
171,032 - Rv0144 0.89 -0.4
171,032 - Rv0144 0.89 -0.0
171,032 - Rv0144 0.89 +0.0
171,033 + Rv0144 0.89 +0.6
171,052 + -0.7
171,052 + -0.4
171,052 + +2.0
171,201 + +0.5
171,202 - -0.4
171,202 - -0.1
171,489 - Rv0145 0.29 -0.7
171,521 + Rv0145 0.32 -0.6
171,657 - Rv0145 0.46 -0.2
171,657 - Rv0145 0.46 +0.2
171,753 + Rv0145 0.56 -1.0
171,753 + Rv0145 0.56 -0.8
171,808 - Rv0145 0.62 -0.1
171,958 - Rv0145 0.78 -0.6
171,984 - Rv0145 0.81 -0.3
172,399 - Rv0146 0.20 -0.4
172,487 - Rv0146 0.30 -0.1
172,487 - Rv0146 0.30 +0.1
172,490 + Rv0146 0.30 +0.0
172,490 + Rv0146 0.30 +0.5
172,491 - Rv0146 0.30 -0.8
172,527 + Rv0146 0.34 -0.8
172,595 + Rv0146 0.41 +0.1
172,596 - Rv0146 0.41 -0.2
172,625 + Rv0146 0.44 +2.2
172,625 + Rv0146 0.44 +1.3
172,625 + Rv0146 0.44 +1.0
172,625 + Rv0146 0.44 -0.1
172,626 - Rv0146 0.44 +0.2
172,626 - Rv0146 0.44 -0.3
172,781 + Rv0146 0.61 +0.7
172,781 + Rv0146 0.61 +0.7
172,781 + Rv0146 0.61 +0.2
172,782 - Rv0146 0.61 -1.9
172,782 - Rv0146 0.61 -0.4
172,782 - Rv0146 0.61 +0.2
172,784 - Rv0146 0.61 +0.2
172,785 + Rv0146 0.62 -1.1
172,970 + Rv0146 0.81 +1.3
172,971 - Rv0146 0.81 -0.0
172,971 - Rv0146 0.81 -0.4
173,141 + -0.1
173,141 + +0.1
173,142 - -0.4
173,164 + +0.7
173,164 + -0.0
173,164 + +0.3
173,164 + -0.5
173,164 + +1.3
173,164 + +0.3
173,164 + -0.1
173,164 + +0.3
173,164 + -1.0
173,164 + +1.0
173,165 - +0.0
173,165 - -0.4
173,165 - -0.4
173,165 - -0.1
173,165 - -0.9
173,165 - +1.7
173,165 - +0.1
173,165 - -0.5
173,166 + +0.9
173,166 + +0.4
173,167 - -0.2
173,167 - +0.5
173,167 - -0.3
173,168 + +0.9

Or see this region's nucleotide sequence