Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2621c

Experiment: 7H9 with Nickel (II) chloride 0.6 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2618 and Rv2619c overlap by 16 nucleotidesRv2619c and Rv2620c are separated by 12 nucleotidesRv2620c and Rv2621c overlap by 4 nucleotidesRv2621c and Rv2622 are separated by 77 nucleotides Rv2618: Rv2618 - Conserved hypothetical protein, at 2,946,434 to 2,947,111 Rv2618 Rv2619c: Rv2619c - Conserved protein, at 2,947,096 to 2,947,449 Rv2619c Rv2620c: Rv2620c - Probable conserved transmembrane protein, at 2,947,462 to 2,947,887 Rv2620c Rv2621c: Rv2621c - Possible transcriptional regulatory protein, at 2,947,884 to 2,948,558 Rv2621c Rv2622: Rv2622 - Possible methyltransferase (methylase), at 2,948,636 to 2,949,457 Rv2622 Position (kb) 2947 2948 2949Strain fitness (log2 ratio) -2 -1 0 1 2at 2946.982 kb on + strand, within Rv2618at 2947.074 kb on + strandat 2947.075 kb on - strandat 2947.075 kb on - strandat 2947.075 kb on - strandat 2947.199 kb on + strand, within Rv2619cat 2947.200 kb on - strand, within Rv2619cat 2947.200 kb on - strand, within Rv2619cat 2947.200 kb on - strand, within Rv2619cat 2947.475 kb on - strandat 2947.481 kb on - strandat 2947.513 kb on + strand, within Rv2620cat 2947.513 kb on + strand, within Rv2620cat 2947.514 kb on - strand, within Rv2620cat 2947.529 kb on + strand, within Rv2620cat 2947.529 kb on + strand, within Rv2620cat 2947.529 kb on + strand, within Rv2620cat 2947.529 kb on + strand, within Rv2620cat 2947.529 kb on + strand, within Rv2620cat 2947.530 kb on - strand, within Rv2620cat 2947.530 kb on - strand, within Rv2620cat 2947.530 kb on - strand, within Rv2620cat 2947.530 kb on - strand, within Rv2620cat 2947.573 kb on + strand, within Rv2620cat 2947.573 kb on + strand, within Rv2620cat 2947.574 kb on - strand, within Rv2620cat 2947.574 kb on - strand, within Rv2620cat 2948.007 kb on + strand, within Rv2621cat 2948.007 kb on + strand, within Rv2621cat 2948.558 kb on + strandat 2948.559 kb on - strandat 2948.635 kb on + strandat 2948.635 kb on + strandat 2948.635 kb on + strandat 2948.635 kb on + strandat 2948.635 kb on + strandat 2948.636 kb on - strandat 2948.873 kb on + strand, within Rv2622at 2948.873 kb on + strand, within Rv2622at 2949.277 kb on - strand, within Rv2622at 2949.485 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Nickel (II) chloride 0.6 mM
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2,946,982 + Rv2618 0.81 +0.5
2,947,074 + +0.1
2,947,075 - -0.2
2,947,075 - -0.2
2,947,075 - -0.8
2,947,199 + Rv2619c 0.29 +0.8
2,947,200 - Rv2619c 0.29 -1.0
2,947,200 - Rv2619c 0.29 +0.2
2,947,200 - Rv2619c 0.29 +0.3
2,947,475 - -0.6
2,947,481 - -0.6
2,947,513 + Rv2620c 0.12 -0.0
2,947,513 + Rv2620c 0.12 +2.4
2,947,514 - Rv2620c 0.12 -0.3
2,947,529 + Rv2620c 0.16 -0.2
2,947,529 + Rv2620c 0.16 -0.3
2,947,529 + Rv2620c 0.16 +1.8
2,947,529 + Rv2620c 0.16 -0.4
2,947,529 + Rv2620c 0.16 -0.5
2,947,530 - Rv2620c 0.16 -1.4
2,947,530 - Rv2620c 0.16 +0.2
2,947,530 - Rv2620c 0.16 +1.3
2,947,530 - Rv2620c 0.16 -0.2
2,947,573 + Rv2620c 0.26 -0.9
2,947,573 + Rv2620c 0.26 -1.6
2,947,574 - Rv2620c 0.26 -0.1
2,947,574 - Rv2620c 0.26 -0.5
2,948,007 + Rv2621c 0.18 -0.8
2,948,007 + Rv2621c 0.18 -1.4
2,948,558 + -0.0
2,948,559 - +0.0
2,948,635 + +0.0
2,948,635 + +0.2
2,948,635 + +0.4
2,948,635 + -0.6
2,948,635 + -1.9
2,948,636 - -0.4
2,948,873 + Rv2622 0.29 +0.4
2,948,873 + Rv2622 0.29 -0.8
2,949,277 - Rv2622 0.78 -0.3
2,949,485 + -0.2

Or see this region's nucleotide sequence