Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0490

Experiment: 7H9 with Nickel (II) chloride 0.6 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0489 and Rv0490 are separated by 173 nucleotidesRv0490 and Rv0491 are separated by 227 nucleotidesRv0491 and Rv0492c overlap by 4 nucleotides Rv0489: Rv0489 - Probable phosphoglycerate mutase 1 Gpm1 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM), at 578,426 to 579,175 Rv0489 Rv0490: Rv0490 - Putative two component sensor histidine kinase SenX3, at 579,349 to 580,581 Rv0490 Rv0491: Rv0491 - Two component sensory transduction protein RegX3 (transcriptional regulatory protein) (probably LuxR-family), at 580,809 to 581,492 Rv0491 Rv0492c: Rv0492c - Probable oxidoreductase GMC-type, at 581,489 to 583,378 Rv0492c Position (kb) 579 580 581Strain fitness (log2 ratio) -2 -1 0 1 2at 579.173 kb on + strandat 579.174 kb on - strandat 579.277 kb on + strandat 579.278 kb on - strandat 579.569 kb on - strand, within Rv0490at 579.569 kb on - strand, within Rv0490at 579.593 kb on + strand, within Rv0490at 579.594 kb on - strand, within Rv0490at 579.719 kb on + strand, within Rv0490at 580.033 kb on - strand, within Rv0490at 580.411 kb on - strand, within Rv0490at 580.496 kb on - strandat 580.996 kb on + strand, within Rv0491at 580.996 kb on + strand, within Rv0491at 580.996 kb on + strand, within Rv0491at 580.996 kb on + strand, within Rv0491at 580.996 kb on + strand, within Rv0491at 580.997 kb on - strand, within Rv0491at 580.997 kb on - strand, within Rv0491at 580.997 kb on - strand, within Rv0491at 580.997 kb on - strand, within Rv0491at 580.997 kb on - strand, within Rv0491at 581.100 kb on + strand, within Rv0491at 581.368 kb on - strand, within Rv0491at 581.475 kb on + strandat 581.528 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Nickel (II) chloride 0.6 mM
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579,173 + +0.1
579,174 - -0.5
579,277 + -0.5
579,278 - -0.3
579,569 - Rv0490 0.18 +0.4
579,569 - Rv0490 0.18 -0.4
579,593 + Rv0490 0.20 +1.8
579,594 - Rv0490 0.20 +1.5
579,719 + Rv0490 0.30 +0.1
580,033 - Rv0490 0.55 -0.3
580,411 - Rv0490 0.86 +1.4
580,496 - +0.3
580,996 + Rv0491 0.27 +0.3
580,996 + Rv0491 0.27 +0.1
580,996 + Rv0491 0.27 -1.6
580,996 + Rv0491 0.27 -0.0
580,996 + Rv0491 0.27 -0.2
580,997 - Rv0491 0.27 +0.5
580,997 - Rv0491 0.27 +0.0
580,997 - Rv0491 0.27 -0.5
580,997 - Rv0491 0.27 -0.4
580,997 - Rv0491 0.27 -0.1
581,100 + Rv0491 0.43 -1.0
581,368 - Rv0491 0.82 -0.3
581,475 + -1.8
581,528 + -1.0

Or see this region's nucleotide sequence