Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2634c

Experiment: 7H9 with Geneticin G418 0.35 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2632c and Rv2633c are separated by 144 nucleotidesRv2633c and Rv2634c are separated by 284 nucleotidesRv2634c and Rv2635 are separated by 28 nucleotidesRv2635 and Rv2636 are separated by 0 nucleotides Rv2632c: Rv2632c - Conserved protein, at 2,958,909 to 2,959,190 Rv2632c Rv2633c: Rv2633c - Hypothetical protein, at 2,959,335 to 2,959,820 Rv2633c Rv2634c: Rv2634c - PE-PGRS family protein PE_PGRS46, at 2,960,105 to 2,962,441 Rv2634c Rv2635: Rv2635 - Hypothetical protein, at 2,962,470 to 2,962,712 Rv2635 Rv2636: Rv2636 - Conserved hypothetical protein, at 2,962,713 to 2,963,390 Rv2636 Position (kb) 2960 2961 2962 2963Strain fitness (log2 ratio) -1 0 1 2 3 4at 2959.218 kb on - strandat 2959.239 kb on + strandat 2959.252 kb on + strandat 2959.256 kb on + strandat 2959.256 kb on + strandat 2959.256 kb on + strandat 2959.256 kb on + strandat 2959.257 kb on - strandat 2959.284 kb on + strandat 2959.336 kb on + strandat 2959.336 kb on + strandat 2959.337 kb on - strandat 2959.371 kb on - strandat 2959.382 kb on - strandat 2959.382 kb on - strandat 2959.382 kb on - strandat 2959.382 kb on - strandat 2959.382 kb on - strandat 2959.497 kb on + strand, within Rv2633cat 2959.498 kb on - strand, within Rv2633cat 2959.661 kb on - strand, within Rv2633cat 2959.663 kb on + strand, within Rv2633cat 2959.663 kb on + strand, within Rv2633cat 2959.663 kb on + strand, within Rv2633cat 2959.664 kb on - strand, within Rv2633cat 2959.664 kb on - strand, within Rv2633cat 2959.778 kb on + strandat 2959.800 kb on + strandat 2959.804 kb on - strandat 2959.831 kb on + strandat 2959.862 kb on + strandat 2960.107 kb on - strandat 2960.470 kb on + strand, within Rv2634cat 2960.804 kb on + strand, within Rv2634cat 2960.924 kb on + strand, within Rv2634cat 2960.924 kb on + strand, within Rv2634cat 2960.924 kb on + strand, within Rv2634cat 2961.103 kb on + strand, within Rv2634cat 2961.103 kb on + strand, within Rv2634cat 2961.103 kb on + strand, within Rv2634cat 2961.539 kb on + strand, within Rv2634cat 2961.540 kb on - strand, within Rv2634cat 2962.178 kb on + strand, within Rv2634cat 2962.178 kb on + strand, within Rv2634cat 2962.178 kb on + strand, within Rv2634cat 2962.178 kb on + strand, within Rv2634cat 2962.182 kb on + strand, within Rv2634cat 2962.183 kb on - strand, within Rv2634cat 2962.183 kb on - strand, within Rv2634cat 2962.183 kb on - strand, within Rv2634cat 2962.202 kb on - strand, within Rv2634cat 2962.258 kb on - strandat 2962.270 kb on - strandat 2962.567 kb on - strand, within Rv2635at 2962.944 kb on + strand, within Rv2636at 2962.944 kb on + strand, within Rv2636at 2962.944 kb on + strand, within Rv2636at 2962.945 kb on - strand, within Rv2636at 2962.945 kb on - strand, within Rv2636at 2962.945 kb on - strand, within Rv2636at 2963.265 kb on + strand, within Rv2636at 2963.282 kb on + strand, within Rv2636at 2963.331 kb on + strandat 2963.331 kb on + strandat 2963.331 kb on + strandat 2963.346 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Geneticin G418 0.35 mM
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2,959,218 - -0.2
2,959,239 + -0.3
2,959,252 + +0.4
2,959,256 + -0.6
2,959,256 + -0.8
2,959,256 + +0.0
2,959,256 + -0.1
2,959,257 - -1.6
2,959,284 + +2.0
2,959,336 + -0.7
2,959,336 + -0.6
2,959,337 - +2.7
2,959,371 - +1.5
2,959,382 - +0.6
2,959,382 - -0.2
2,959,382 - -0.1
2,959,382 - +0.9
2,959,382 - +0.4
2,959,497 + Rv2633c 0.33 +0.5
2,959,498 - Rv2633c 0.34 +0.6
2,959,661 - Rv2633c 0.67 +4.3
2,959,663 + Rv2633c 0.67 +1.6
2,959,663 + Rv2633c 0.67 +0.3
2,959,663 + Rv2633c 0.67 +0.1
2,959,664 - Rv2633c 0.68 +1.8
2,959,664 - Rv2633c 0.68 +0.6
2,959,778 + +0.0
2,959,800 + +0.7
2,959,804 - +0.0
2,959,831 + +1.2
2,959,862 + +0.2
2,960,107 - -1.0
2,960,470 + Rv2634c 0.16 -0.9
2,960,804 + Rv2634c 0.30 +0.2
2,960,924 + Rv2634c 0.35 +1.0
2,960,924 + Rv2634c 0.35 +0.2
2,960,924 + Rv2634c 0.35 +1.6
2,961,103 + Rv2634c 0.43 -1.3
2,961,103 + Rv2634c 0.43 -0.3
2,961,103 + Rv2634c 0.43 +0.3
2,961,539 + Rv2634c 0.61 -0.4
2,961,540 - Rv2634c 0.61 -1.3
2,962,178 + Rv2634c 0.89 +0.7
2,962,178 + Rv2634c 0.89 -0.3
2,962,178 + Rv2634c 0.89 -0.2
2,962,178 + Rv2634c 0.89 -0.9
2,962,182 + Rv2634c 0.89 +0.4
2,962,183 - Rv2634c 0.89 +0.3
2,962,183 - Rv2634c 0.89 -0.2
2,962,183 - Rv2634c 0.89 -0.1
2,962,202 - Rv2634c 0.90 +0.9
2,962,258 - -0.2
2,962,270 - +0.7
2,962,567 - Rv2635 0.40 +0.5
2,962,944 + Rv2636 0.34 +2.0
2,962,944 + Rv2636 0.34 -1.1
2,962,944 + Rv2636 0.34 -0.0
2,962,945 - Rv2636 0.34 +0.6
2,962,945 - Rv2636 0.34 +0.2
2,962,945 - Rv2636 0.34 -0.2
2,963,265 + Rv2636 0.81 +1.1
2,963,282 + Rv2636 0.84 -0.4
2,963,331 + -0.7
2,963,331 + -0.5
2,963,331 + +2.0
2,963,346 + -0.1

Or see this region's nucleotide sequence