Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1065

Experiment: 7H9 with Geneticin G418 0.35 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1063c and Rv1064c are separated by 80 nucleotidesRv1064c and Rv1065 are separated by 111 nucleotidesRv1065 and Rv1066 overlap by 4 nucleotidesRv1066 and Rv1067c are separated by 27 nucleotides Rv1063c: Rv1063c - Conserved hypothetical protein, at 1,185,741 to 1,186,823 Rv1063c Rv1064c: Rv1064c - Possible lipoprotein LpqV, at 1,186,904 to 1,187,323 Rv1064c Rv1065: Rv1065 - Conserved hypothetical protein, at 1,187,435 to 1,188,001 Rv1065 Rv1066: Rv1066 - Conserved hypothetical protein, at 1,187,998 to 1,188,393 Rv1066 Rv1067c: Rv1067c - PE-PGRS family protein PE_PGRS19, at 1,188,421 to 1,190,424 Rv1067c Position (kb) 1187 1188 1189Strain fitness (log2 ratio) -3 -2 -1 0 1 2 3at 1186.444 kb on - strand, within Rv1063cat 1186.559 kb on + strand, within Rv1063cat 1186.559 kb on + strand, within Rv1063cat 1186.560 kb on - strand, within Rv1063cat 1186.696 kb on + strand, within Rv1063cat 1187.037 kb on + strand, within Rv1064cat 1187.109 kb on + strand, within Rv1064cat 1187.109 kb on + strand, within Rv1064cat 1187.112 kb on + strand, within Rv1064cat 1187.112 kb on + strand, within Rv1064cat 1187.113 kb on - strand, within Rv1064cat 1187.113 kb on - strand, within Rv1064cat 1187.307 kb on + strandat 1187.334 kb on + strandat 1187.334 kb on + strandat 1187.334 kb on + strandat 1187.335 kb on - strandat 1187.440 kb on + strandat 1187.441 kb on - strandat 1187.603 kb on + strand, within Rv1065at 1187.603 kb on + strand, within Rv1065at 1187.603 kb on + strand, within Rv1065at 1187.635 kb on + strand, within Rv1065at 1187.636 kb on - strand, within Rv1065at 1187.648 kb on - strand, within Rv1065at 1187.648 kb on - strand, within Rv1065at 1187.648 kb on - strand, within Rv1065at 1187.897 kb on + strand, within Rv1065at 1187.928 kb on - strand, within Rv1065at 1188.392 kb on - strandat 1188.392 kb on - strandat 1188.392 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Geneticin G418 0.35 mM
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1,186,444 - Rv1063c 0.65 -0.7
1,186,559 + Rv1063c 0.76 -2.4
1,186,559 + Rv1063c 0.76 -0.1
1,186,560 - Rv1063c 0.76 +1.5
1,186,696 + Rv1063c 0.88 -1.2
1,187,037 + Rv1064c 0.32 +0.5
1,187,109 + Rv1064c 0.49 +0.5
1,187,109 + Rv1064c 0.49 -0.7
1,187,112 + Rv1064c 0.50 +3.1
1,187,112 + Rv1064c 0.50 -0.7
1,187,113 - Rv1064c 0.50 +2.1
1,187,113 - Rv1064c 0.50 -0.5
1,187,307 + -1.3
1,187,334 + -1.2
1,187,334 + -1.7
1,187,334 + -1.5
1,187,335 - -1.1
1,187,440 + -0.0
1,187,441 - -0.9
1,187,603 + Rv1065 0.30 -0.5
1,187,603 + Rv1065 0.30 -1.2
1,187,603 + Rv1065 0.30 -1.4
1,187,635 + Rv1065 0.35 -0.3
1,187,636 - Rv1065 0.35 -1.2
1,187,648 - Rv1065 0.38 -2.0
1,187,648 - Rv1065 0.38 +0.2
1,187,648 - Rv1065 0.38 +0.7
1,187,897 + Rv1065 0.81 -3.2
1,187,928 - Rv1065 0.87 -0.2
1,188,392 - -0.4
1,188,392 - -0.6
1,188,392 - +0.1

Or see this region's nucleotide sequence