Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2487c

Experiment: 7H9 with Sisomicin 0.07 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2486 and Rv2487c are separated by 180 nucleotidesRv2487c and Rv2488c are separated by 81 nucleotides Rv2486: Rv2486 - Probable enoyl-CoA hydratase EchA14 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase), at 2,794,350 to 2,795,120 Rv2486 Rv2487c: Rv2487c - PE-PGRS family protein PE_PGRS42, at 2,795,301 to 2,797,385 Rv2487c Rv2488c: Rv2488c - Probable transcriptional regulatory protein (LuxR-family), at 2,797,467 to 2,800,880 Rv2488c Position (kb) 2795 2796 2797 2798Strain fitness (log2 ratio) -1 0 1 2at 2794.359 kb on + strandat 2794.498 kb on + strand, within Rv2486at 2794.499 kb on - strand, within Rv2486at 2794.507 kb on + strand, within Rv2486at 2794.600 kb on + strand, within Rv2486at 2794.631 kb on + strand, within Rv2486at 2794.631 kb on + strand, within Rv2486at 2794.631 kb on + strand, within Rv2486at 2794.632 kb on - strand, within Rv2486at 2794.637 kb on + strand, within Rv2486at 2794.638 kb on - strand, within Rv2486at 2794.638 kb on - strand, within Rv2486at 2794.835 kb on - strand, within Rv2486at 2795.044 kb on + strandat 2795.118 kb on + strandat 2795.118 kb on + strandat 2795.126 kb on - strandat 2795.212 kb on + strandat 2795.212 kb on + strandat 2795.213 kb on - strandat 2795.236 kb on + strandat 2795.600 kb on + strand, within Rv2487cat 2795.803 kb on - strand, within Rv2487cat 2796.201 kb on + strand, within Rv2487cat 2796.202 kb on - strand, within Rv2487cat 2796.381 kb on + strand, within Rv2487cat 2796.722 kb on + strand, within Rv2487cat 2797.201 kb on + strandat 2797.333 kb on - strandat 2797.407 kb on + strandat 2797.469 kb on - strandat 2797.555 kb on + strandat 2797.556 kb on - strandat 2797.599 kb on + strandat 2797.600 kb on - strandat 2797.971 kb on + strand, within Rv2488cat 2797.972 kb on - strand, within Rv2488cat 2797.972 kb on - strand, within Rv2488cat 2797.972 kb on - strand, within Rv2488cat 2797.975 kb on + strand, within Rv2488cat 2797.975 kb on + strand, within Rv2488cat 2797.976 kb on - strand, within Rv2488cat 2797.976 kb on - strand, within Rv2488cat 2797.976 kb on - strand, within Rv2488cat 2797.976 kb on - strand, within Rv2488c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Sisomicin 0.07 mM
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2,794,359 + -0.5
2,794,498 + Rv2486 0.19 +0.5
2,794,499 - Rv2486 0.19 -0.1
2,794,507 + Rv2486 0.20 +0.0
2,794,600 + Rv2486 0.32 +0.3
2,794,631 + Rv2486 0.36 +0.1
2,794,631 + Rv2486 0.36 -0.7
2,794,631 + Rv2486 0.36 +0.1
2,794,632 - Rv2486 0.37 -0.5
2,794,637 + Rv2486 0.37 +0.6
2,794,638 - Rv2486 0.37 +0.1
2,794,638 - Rv2486 0.37 -0.3
2,794,835 - Rv2486 0.63 -0.4
2,795,044 + -0.7
2,795,118 + +1.4
2,795,118 + -0.3
2,795,126 - -0.5
2,795,212 + -0.2
2,795,212 + -0.2
2,795,213 - +0.1
2,795,236 + -0.4
2,795,600 + Rv2487c 0.14 -0.7
2,795,803 - Rv2487c 0.24 -0.3
2,796,201 + Rv2487c 0.43 +2.1
2,796,202 - Rv2487c 0.43 +1.1
2,796,381 + Rv2487c 0.52 +0.0
2,796,722 + Rv2487c 0.68 +1.6
2,797,201 + -0.2
2,797,333 - -1.2
2,797,407 + -0.6
2,797,469 - -0.0
2,797,555 + -0.3
2,797,556 - -0.5
2,797,599 + -1.4
2,797,600 - -1.2
2,797,971 + Rv2488c 0.15 +1.3
2,797,972 - Rv2488c 0.15 +0.7
2,797,972 - Rv2488c 0.15 +0.0
2,797,972 - Rv2488c 0.15 -0.2
2,797,975 + Rv2488c 0.15 -1.5
2,797,975 + Rv2488c 0.15 -0.9
2,797,976 - Rv2488c 0.15 -0.1
2,797,976 - Rv2488c 0.15 +1.6
2,797,976 - Rv2488c 0.15 -0.4
2,797,976 - Rv2488c 0.15 +0.1

Or see this region's nucleotide sequence