Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3761c

Experiment: 7H9 with Sisomicin 0.07 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3759c and Rv3760 are separated by 164 nucleotidesRv3760 and Rv3761c are separated by 21 nucleotidesRv3761c and Rv3762c are separated by 78 nucleotides Rv3759c: Rv3759c - Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein ProX, at 4,204,426 to 4,205,373 Rv3759c Rv3760: Rv3760 - Possible conserved membrane protein, at 4,205,538 to 4,205,840 Rv3760 Rv3761c: Rv3761c - Possible acyl-CoA dehydrogenase FadE36, at 4,205,862 to 4,206,917 Rv3761c Rv3762c: Rv3762c - Possible hydrolase, at 4,206,996 to 4,208,876 Rv3762c Position (kb) 4205 4206 4207Strain fitness (log2 ratio) -2 -1 0 1 2 3at 4205.007 kb on - strand, within Rv3759cat 4205.007 kb on - strand, within Rv3759cat 4205.060 kb on + strand, within Rv3759cat 4205.080 kb on - strand, within Rv3759cat 4205.127 kb on - strand, within Rv3759cat 4205.127 kb on - strand, within Rv3759cat 4205.426 kb on - strandat 4205.719 kb on + strand, within Rv3760at 4205.730 kb on - strand, within Rv3760at 4206.049 kb on - strand, within Rv3761cat 4206.073 kb on + strand, within Rv3761cat 4206.074 kb on - strand, within Rv3761cat 4206.141 kb on + strand, within Rv3761cat 4206.142 kb on - strand, within Rv3761cat 4206.142 kb on - strand, within Rv3761cat 4206.165 kb on + strand, within Rv3761cat 4206.166 kb on - strand, within Rv3761cat 4206.483 kb on - strand, within Rv3761cat 4206.778 kb on + strand, within Rv3761cat 4206.929 kb on - strandat 4206.953 kb on - strandat 4207.101 kb on - strandat 4207.191 kb on + strand, within Rv3762cat 4207.192 kb on - strand, within Rv3762cat 4207.192 kb on - strand, within Rv3762cat 4207.613 kb on - strand, within Rv3762cat 4207.681 kb on + strand, within Rv3762cat 4207.681 kb on + strand, within Rv3762cat 4207.681 kb on + strand, within Rv3762cat 4207.682 kb on - strand, within Rv3762cat 4207.798 kb on + strand, within Rv3762cat 4207.838 kb on - strand, within Rv3762cat 4207.838 kb on - strand, within Rv3762cat 4207.838 kb on - strand, within Rv3762cat 4207.843 kb on + strand, within Rv3762cat 4207.843 kb on + strand, within Rv3762cat 4207.843 kb on + strand, within Rv3762cat 4207.844 kb on - strand, within Rv3762cat 4207.844 kb on - strand, within Rv3762c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Sisomicin 0.07 mM
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4,205,007 - Rv3759c 0.61 +0.8
4,205,007 - Rv3759c 0.61 +3.0
4,205,060 + Rv3759c 0.67 +2.0
4,205,080 - Rv3759c 0.69 -1.1
4,205,127 - Rv3759c 0.74 -0.3
4,205,127 - Rv3759c 0.74 -0.3
4,205,426 - -1.1
4,205,719 + Rv3760 0.60 -0.9
4,205,730 - Rv3760 0.63 -0.7
4,206,049 - Rv3761c 0.18 -0.8
4,206,073 + Rv3761c 0.20 -0.9
4,206,074 - Rv3761c 0.20 -0.9
4,206,141 + Rv3761c 0.26 -1.8
4,206,142 - Rv3761c 0.27 +1.3
4,206,142 - Rv3761c 0.27 -1.6
4,206,165 + Rv3761c 0.29 -0.3
4,206,166 - Rv3761c 0.29 -1.3
4,206,483 - Rv3761c 0.59 -0.2
4,206,778 + Rv3761c 0.87 -0.7
4,206,929 - +3.0
4,206,953 - -2.4
4,207,101 - -0.6
4,207,191 + Rv3762c 0.10 +0.8
4,207,192 - Rv3762c 0.10 -1.5
4,207,192 - Rv3762c 0.10 -1.8
4,207,613 - Rv3762c 0.33 -0.3
4,207,681 + Rv3762c 0.36 +1.7
4,207,681 + Rv3762c 0.36 -0.6
4,207,681 + Rv3762c 0.36 -0.9
4,207,682 - Rv3762c 0.36 +0.1
4,207,798 + Rv3762c 0.43 -0.2
4,207,838 - Rv3762c 0.45 +0.6
4,207,838 - Rv3762c 0.45 +1.5
4,207,838 - Rv3762c 0.45 -0.1
4,207,843 + Rv3762c 0.45 +0.1
4,207,843 + Rv3762c 0.45 +0.2
4,207,843 + Rv3762c 0.45 +0.2
4,207,844 - Rv3762c 0.45 +0.4
4,207,844 - Rv3762c 0.45 -1.4

Or see this region's nucleotide sequence