Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1957

Experiment: 7H9 with nitrite 2.5 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1954c and Rv1955 overlap by 26 nucleotidesRv1955 and Rv1956 are separated by 41 nucleotidesRv1956 and Rv1957 overlap by 4 nucleotidesRv1957 and Rv1958c overlap by 112 nucleotidesRv1958c and Rv1959c are separated by 48 nucleotidesRv1959c and Rv1960c overlap by 4 nucleotides Rv1954c: Rv1954c - Hypothetical protein, at 2,201,223 to 2,201,744 Rv1954c Rv1955: Rv1955 - Possible toxin HigB, at 2,201,719 to 2,202,096 Rv1955 Rv1956: Rv1956 - Possible antitoxin HigA, at 2,202,138 to 2,202,587 Rv1956 Rv1957: Rv1957 - Hypothetical protein, at 2,202,584 to 2,203,129 Rv1957 Rv1958c: Rv1958c - Hypothetical protein, at 2,203,018 to 2,203,632 Rv1958c Rv1959c: Rv1959c - Possible toxin ParE1, at 2,203,681 to 2,203,977 Rv1959c Rv1960c: Rv1960c - Possible antitoxin ParD1, at 2,203,974 to 2,204,225 Rv1960c Position (kb) 2202 2203 2204Strain fitness (log2 ratio) -2 -1 0 1 2 3at 2201.633 kb on + strandat 2201.633 kb on + strandat 2201.633 kb on + strandat 2201.633 kb on + strandat 2201.633 kb on + strandat 2201.634 kb on - strandat 2201.634 kb on - strandat 2201.634 kb on - strandat 2201.634 kb on - strandat 2201.748 kb on + strandat 2201.748 kb on + strandat 2201.748 kb on + strandat 2201.749 kb on - strandat 2201.846 kb on + strand, within Rv1955at 2201.846 kb on + strand, within Rv1955at 2201.857 kb on + strand, within Rv1955at 2201.858 kb on - strand, within Rv1955at 2201.999 kb on - strand, within Rv1955at 2202.115 kb on + strandat 2202.115 kb on + strandat 2202.123 kb on + strandat 2202.314 kb on + strand, within Rv1956at 2202.377 kb on + strand, within Rv1956at 2202.377 kb on + strand, within Rv1956at 2202.377 kb on + strand, within Rv1956at 2202.390 kb on + strand, within Rv1956at 2202.390 kb on + strand, within Rv1956at 2202.455 kb on + strand, within Rv1956at 2202.455 kb on + strand, within Rv1956at 2202.456 kb on - strand, within Rv1956at 2202.729 kb on - strand, within Rv1957at 2202.729 kb on - strand, within Rv1957at 2202.729 kb on - strand, within Rv1957at 2202.773 kb on - strand, within Rv1957at 2203.065 kb on + strandat 2203.065 kb on + strandat 2203.065 kb on + strandat 2203.066 kb on - strandat 2203.178 kb on - strand, within Rv1958cat 2203.178 kb on - strand, within Rv1958cat 2203.438 kb on - strand, within Rv1958cat 2203.529 kb on - strand, within Rv1958cat 2203.546 kb on + strand, within Rv1958cat 2203.546 kb on + strand, within Rv1958cat 2203.546 kb on + strand, within Rv1958cat 2203.547 kb on - strand, within Rv1958cat 2203.547 kb on - strand, within Rv1958cat 2203.547 kb on - strand, within Rv1958cat 2203.547 kb on - strand, within Rv1958cat 2203.877 kb on + strand, within Rv1959cat 2203.877 kb on + strand, within Rv1959cat 2203.877 kb on + strand, within Rv1959cat 2203.878 kb on - strand, within Rv1959cat 2203.910 kb on + strand, within Rv1959cat 2203.910 kb on + strand, within Rv1959cat 2203.911 kb on - strand, within Rv1959cat 2203.911 kb on - strand, within Rv1959cat 2203.964 kb on + strandat 2203.964 kb on + strandat 2204.003 kb on + strand, within Rv1960cat 2204.003 kb on + strand, within Rv1960c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with nitrite 2.5 mM
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2,201,633 + +0.0
2,201,633 + -2.0
2,201,633 + +1.3
2,201,633 + +1.1
2,201,633 + +0.3
2,201,634 - -0.2
2,201,634 - -0.2
2,201,634 - +0.5
2,201,634 - +2.9
2,201,748 + -0.4
2,201,748 + -0.3
2,201,748 + -0.2
2,201,749 - +0.2
2,201,846 + Rv1955 0.34 -0.3
2,201,846 + Rv1955 0.34 -0.4
2,201,857 + Rv1955 0.37 -0.1
2,201,858 - Rv1955 0.37 +0.2
2,201,999 - Rv1955 0.74 -0.1
2,202,115 + -0.1
2,202,115 + -0.7
2,202,123 + -0.1
2,202,314 + Rv1956 0.39 +1.4
2,202,377 + Rv1956 0.53 -0.2
2,202,377 + Rv1956 0.53 +0.2
2,202,377 + Rv1956 0.53 -0.0
2,202,390 + Rv1956 0.56 -0.1
2,202,390 + Rv1956 0.56 -0.5
2,202,455 + Rv1956 0.70 +1.9
2,202,455 + Rv1956 0.70 +0.5
2,202,456 - Rv1956 0.71 +0.7
2,202,729 - Rv1957 0.27 -0.7
2,202,729 - Rv1957 0.27 +0.5
2,202,729 - Rv1957 0.27 +1.9
2,202,773 - Rv1957 0.35 -2.2
2,203,065 + +0.1
2,203,065 + +1.0
2,203,065 + -1.7
2,203,066 - -1.2
2,203,178 - Rv1958c 0.26 -0.5
2,203,178 - Rv1958c 0.26 +1.9
2,203,438 - Rv1958c 0.68 -0.8
2,203,529 - Rv1958c 0.83 -0.4
2,203,546 + Rv1958c 0.86 -0.1
2,203,546 + Rv1958c 0.86 -0.9
2,203,546 + Rv1958c 0.86 +0.3
2,203,547 - Rv1958c 0.86 -0.3
2,203,547 - Rv1958c 0.86 +0.4
2,203,547 - Rv1958c 0.86 -0.9
2,203,547 - Rv1958c 0.86 +1.5
2,203,877 + Rv1959c 0.66 +1.5
2,203,877 + Rv1959c 0.66 -0.1
2,203,877 + Rv1959c 0.66 +0.7
2,203,878 - Rv1959c 0.66 -0.3
2,203,910 + Rv1959c 0.77 -0.2
2,203,910 + Rv1959c 0.77 +0.6
2,203,911 - Rv1959c 0.77 +0.9
2,203,911 - Rv1959c 0.77 +0.0
2,203,964 + -1.3
2,203,964 + +0.6
2,204,003 + Rv1960c 0.12 -0.0
2,204,003 + Rv1960c 0.12 -0.5

Or see this region's nucleotide sequence