Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2349c

Experiment: 7H9 with copper (II) chloride 0.08 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2346c and Rv2347c are separated by 50 nucleotidesRv2347c and Rv2348c are separated by 134 nucleotidesRv2348c and Rv2349c are separated by 191 nucleotidesRv2349c and Rv2350c are separated by 82 nucleotides Rv2346c: Rv2346c - Putative ESAT-6 like protein EsxO (ESAT-6 like protein 6), at 2,625,888 to 2,626,172 Rv2346c Rv2347c: Rv2347c - Putative ESAT-6 like protein EsxP (ESAT-6 like protein 7), at 2,626,223 to 2,626,519 Rv2347c Rv2348c: Rv2348c - Hypothetical protein, at 2,626,654 to 2,626,980 Rv2348c Rv2349c: Rv2349c - Probable phospholipase C 3 PlcC, at 2,627,172 to 2,628,698 Rv2349c Rv2350c: Rv2350c - Membrane-associated phospholipase C 2 PlcB, at 2,628,781 to 2,630,319 Rv2350c Position (kb) 2627 2628 2629Strain fitness (log2 ratio) -2 -1 0 1 2 3 4at 2626.856 kb on + strand, within Rv2348cat 2627.058 kb on + strandat 2627.058 kb on + strandat 2627.058 kb on + strandat 2627.059 kb on - strandat 2627.059 kb on - strandat 2627.059 kb on - strandat 2627.077 kb on + strandat 2627.078 kb on - strandat 2627.152 kb on + strandat 2627.152 kb on + strandat 2627.152 kb on + strandat 2627.153 kb on - strandat 2627.153 kb on - strandat 2627.384 kb on + strand, within Rv2349cat 2627.385 kb on - strand, within Rv2349cat 2627.385 kb on - strand, within Rv2349cat 2627.509 kb on + strand, within Rv2349cat 2627.562 kb on + strand, within Rv2349cat 2627.563 kb on - strand, within Rv2349cat 2627.681 kb on - strand, within Rv2349cat 2627.736 kb on + strand, within Rv2349cat 2627.869 kb on + strand, within Rv2349cat 2627.888 kb on - strand, within Rv2349cat 2627.945 kb on + strand, within Rv2349cat 2627.993 kb on - strand, within Rv2349cat 2627.993 kb on - strand, within Rv2349cat 2628.143 kb on + strand, within Rv2349cat 2628.144 kb on - strand, within Rv2349cat 2628.176 kb on - strand, within Rv2349cat 2628.197 kb on + strand, within Rv2349cat 2628.197 kb on + strand, within Rv2349cat 2628.198 kb on - strand, within Rv2349cat 2628.198 kb on - strand, within Rv2349cat 2628.212 kb on - strand, within Rv2349cat 2628.212 kb on - strand, within Rv2349cat 2628.222 kb on + strand, within Rv2349cat 2628.223 kb on - strand, within Rv2349cat 2628.238 kb on + strand, within Rv2349cat 2628.238 kb on + strand, within Rv2349cat 2628.238 kb on + strand, within Rv2349cat 2628.238 kb on + strand, within Rv2349cat 2628.239 kb on - strand, within Rv2349cat 2628.239 kb on - strand, within Rv2349cat 2628.239 kb on - strand, within Rv2349cat 2628.239 kb on - strand, within Rv2349cat 2628.241 kb on + strand, within Rv2349cat 2628.241 kb on + strand, within Rv2349cat 2628.242 kb on - strand, within Rv2349cat 2628.242 kb on - strand, within Rv2349cat 2628.410 kb on - strand, within Rv2349cat 2628.419 kb on + strand, within Rv2349cat 2628.419 kb on + strand, within Rv2349cat 2628.419 kb on + strand, within Rv2349cat 2628.420 kb on - strand, within Rv2349cat 2628.420 kb on - strand, within Rv2349cat 2628.420 kb on - strand, within Rv2349cat 2628.420 kb on - strand, within Rv2349cat 2628.420 kb on - strand, within Rv2349cat 2628.420 kb on - strand, within Rv2349cat 2628.524 kb on - strand, within Rv2349cat 2628.550 kb on - strandat 2628.607 kb on + strandat 2628.607 kb on + strandat 2628.608 kb on - strandat 2628.608 kb on - strandat 2628.608 kb on - strandat 2628.674 kb on + strandat 2628.675 kb on - strandat 2628.675 kb on - strandat 2628.743 kb on + strandat 2628.744 kb on - strandat 2628.890 kb on - strandat 2628.890 kb on - strandat 2629.122 kb on + strand, within Rv2350cat 2629.292 kb on + strand, within Rv2350cat 2629.292 kb on + strand, within Rv2350cat 2629.293 kb on - strand, within Rv2350cat 2629.481 kb on + strand, within Rv2350cat 2629.559 kb on + strand, within Rv2350cat 2629.605 kb on - strand, within Rv2350cat 2629.605 kb on - strand, within Rv2350cat 2629.605 kb on - strand, within Rv2350cat 2629.661 kb on + strand, within Rv2350cat 2629.662 kb on - strand, within Rv2350cat 2629.662 kb on - strand, within Rv2350cat 2629.678 kb on + strand, within Rv2350cat 2629.681 kb on - strand, within Rv2350c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with copper (II) chloride 0.08 mM
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2,626,856 + Rv2348c 0.62 +0.1
2,627,058 + -0.5
2,627,058 + -0.3
2,627,058 + -0.6
2,627,059 - -1.0
2,627,059 - -0.6
2,627,059 - +1.7
2,627,077 + +0.6
2,627,078 - -0.1
2,627,152 + +0.4
2,627,152 + -1.3
2,627,152 + -1.2
2,627,153 - +0.1
2,627,153 - +0.2
2,627,384 + Rv2349c 0.14 -0.5
2,627,385 - Rv2349c 0.14 -0.6
2,627,385 - Rv2349c 0.14 +0.9
2,627,509 + Rv2349c 0.22 +4.0
2,627,562 + Rv2349c 0.26 +0.8
2,627,563 - Rv2349c 0.26 -0.3
2,627,681 - Rv2349c 0.33 +0.1
2,627,736 + Rv2349c 0.37 -0.5
2,627,869 + Rv2349c 0.46 +1.2
2,627,888 - Rv2349c 0.47 -0.9
2,627,945 + Rv2349c 0.51 -0.3
2,627,993 - Rv2349c 0.54 +1.8
2,627,993 - Rv2349c 0.54 -0.1
2,628,143 + Rv2349c 0.64 +1.1
2,628,144 - Rv2349c 0.64 -0.4
2,628,176 - Rv2349c 0.66 -1.6
2,628,197 + Rv2349c 0.67 +0.4
2,628,197 + Rv2349c 0.67 -0.4
2,628,198 - Rv2349c 0.67 -0.3
2,628,198 - Rv2349c 0.67 -0.1
2,628,212 - Rv2349c 0.68 -1.3
2,628,212 - Rv2349c 0.68 -0.0
2,628,222 + Rv2349c 0.69 -0.7
2,628,223 - Rv2349c 0.69 +0.6
2,628,238 + Rv2349c 0.70 +1.7
2,628,238 + Rv2349c 0.70 +0.4
2,628,238 + Rv2349c 0.70 +1.2
2,628,238 + Rv2349c 0.70 +1.1
2,628,239 - Rv2349c 0.70 +0.7
2,628,239 - Rv2349c 0.70 -0.4
2,628,239 - Rv2349c 0.70 -0.2
2,628,239 - Rv2349c 0.70 +1.7
2,628,241 + Rv2349c 0.70 +1.7
2,628,241 + Rv2349c 0.70 -0.3
2,628,242 - Rv2349c 0.70 -2.3
2,628,242 - Rv2349c 0.70 -0.0
2,628,410 - Rv2349c 0.81 -0.9
2,628,419 + Rv2349c 0.82 +0.4
2,628,419 + Rv2349c 0.82 +0.8
2,628,419 + Rv2349c 0.82 -0.5
2,628,420 - Rv2349c 0.82 -1.7
2,628,420 - Rv2349c 0.82 -0.7
2,628,420 - Rv2349c 0.82 -0.0
2,628,420 - Rv2349c 0.82 +0.2
2,628,420 - Rv2349c 0.82 +0.2
2,628,420 - Rv2349c 0.82 -1.1
2,628,524 - Rv2349c 0.89 -0.4
2,628,550 - -0.1
2,628,607 + -0.3
2,628,607 + -1.3
2,628,608 - +1.1
2,628,608 - -0.3
2,628,608 - -0.8
2,628,674 + -1.1
2,628,675 - -2.5
2,628,675 - -0.0
2,628,743 + -0.9
2,628,744 - -0.1
2,628,890 - +0.7
2,628,890 - -0.3
2,629,122 + Rv2350c 0.22 +1.7
2,629,292 + Rv2350c 0.33 +0.2
2,629,292 + Rv2350c 0.33 +0.2
2,629,293 - Rv2350c 0.33 +2.1
2,629,481 + Rv2350c 0.45 +0.1
2,629,559 + Rv2350c 0.51 -0.1
2,629,605 - Rv2350c 0.54 -1.0
2,629,605 - Rv2350c 0.54 -0.7
2,629,605 - Rv2350c 0.54 -0.4
2,629,661 + Rv2350c 0.57 -0.0
2,629,662 - Rv2350c 0.57 -0.1
2,629,662 - Rv2350c 0.57 +1.7
2,629,678 + Rv2350c 0.58 -2.5
2,629,681 - Rv2350c 0.58 -0.8

Or see this region's nucleotide sequence