Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1217c

Experiment: 7H9 with copper (II) chloride 0.08 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1215c and Rv1216c are separated by 27 nucleotidesRv1216c and Rv1217c are separated by 8 nucleotidesRv1217c and Rv1218c overlap by 4 nucleotidesRv1218c and Rv1219c overlap by 11 nucleotides Rv1215c: Rv1215c - Conserved protein, at 1,357,759 to 1,359,444 Rv1215c Rv1216c: Rv1216c - Probable conserved integral membrane protein, at 1,359,472 to 1,360,146 Rv1216c Rv1217c: Rv1217c - Probable tetronasin-transport integral membrane protein ABC transporter, at 1,360,155 to 1,361,801 Rv1217c Rv1218c: Rv1218c - Probable tetronasin-transport ATP-binding protein ABC transporter, at 1,361,798 to 1,362,733 Rv1218c Rv1219c: Rv1219c - Probable transcriptional regulatory protein, at 1,362,723 to 1,363,361 Rv1219c Position (kb) 1360 1361 1362Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 1359.457 kb on - strandat 1359.457 kb on - strandat 1359.483 kb on - strandat 1359.515 kb on + strandat 1359.638 kb on - strand, within Rv1216cat 1359.668 kb on + strand, within Rv1216cat 1359.669 kb on - strand, within Rv1216cat 1359.693 kb on - strand, within Rv1216cat 1359.693 kb on - strand, within Rv1216cat 1359.693 kb on - strand, within Rv1216cat 1359.712 kb on + strand, within Rv1216cat 1359.713 kb on - strand, within Rv1216cat 1359.749 kb on + strand, within Rv1216cat 1359.750 kb on - strand, within Rv1216cat 1359.849 kb on - strand, within Rv1216cat 1359.995 kb on + strand, within Rv1216cat 1359.996 kb on - strand, within Rv1216cat 1360.121 kb on - strandat 1360.126 kb on + strandat 1360.126 kb on + strandat 1360.157 kb on - strandat 1360.336 kb on + strand, within Rv1217cat 1360.423 kb on - strand, within Rv1217cat 1360.507 kb on + strand, within Rv1217cat 1360.508 kb on - strand, within Rv1217cat 1360.659 kb on + strand, within Rv1217cat 1361.531 kb on - strand, within Rv1217cat 1361.570 kb on + strand, within Rv1217cat 1361.635 kb on + strand, within Rv1217cat 1361.704 kb on + strandat 1361.847 kb on + strandat 1362.078 kb on - strand, within Rv1218cat 1362.328 kb on - strand, within Rv1218cat 1362.567 kb on - strand, within Rv1218cat 1362.772 kb on + strandat 1362.772 kb on + strandat 1362.773 kb on - strandat 1362.773 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with copper (II) chloride 0.08 mM
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1,359,457 - +0.1
1,359,457 - -2.2
1,359,483 - -0.5
1,359,515 + -0.2
1,359,638 - Rv1216c 0.25 -2.2
1,359,668 + Rv1216c 0.29 +1.3
1,359,669 - Rv1216c 0.29 +0.1
1,359,693 - Rv1216c 0.33 +0.2
1,359,693 - Rv1216c 0.33 -1.1
1,359,693 - Rv1216c 0.33 -0.9
1,359,712 + Rv1216c 0.36 -1.0
1,359,713 - Rv1216c 0.36 -0.4
1,359,749 + Rv1216c 0.41 +1.1
1,359,750 - Rv1216c 0.41 -1.2
1,359,849 - Rv1216c 0.56 +1.2
1,359,995 + Rv1216c 0.77 -0.9
1,359,996 - Rv1216c 0.78 -0.1
1,360,121 - -0.4
1,360,126 + +2.0
1,360,126 + +0.7
1,360,157 - -0.4
1,360,336 + Rv1217c 0.11 -1.5
1,360,423 - Rv1217c 0.16 -1.6
1,360,507 + Rv1217c 0.21 -1.0
1,360,508 - Rv1217c 0.21 +0.6
1,360,659 + Rv1217c 0.31 -0.3
1,361,531 - Rv1217c 0.84 -3.4
1,361,570 + Rv1217c 0.86 +0.2
1,361,635 + Rv1217c 0.90 -1.5
1,361,704 + +0.1
1,361,847 + +0.6
1,362,078 - Rv1218c 0.30 -2.8
1,362,328 - Rv1218c 0.57 +0.4
1,362,567 - Rv1218c 0.82 -0.3
1,362,772 + +0.6
1,362,772 + -0.1
1,362,773 - +0.1
1,362,773 - -0.5

Or see this region's nucleotide sequence