Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2618

Experiment: 7H9 with copper (II) chloride 0.08 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2616 and Rv2617c are separated by 16 nucleotidesRv2617c and Rv2618 are separated by 146 nucleotidesRv2618 and Rv2619c overlap by 16 nucleotidesRv2619c and Rv2620c are separated by 12 nucleotidesRv2620c and Rv2621c overlap by 4 nucleotides Rv2616: Rv2616 - Conserved protein, at 2,945,330 to 2,945,830 Rv2616 Rv2617c: Rv2617c - Probable transmembrane protein, at 2,945,847 to 2,946,287 Rv2617c Rv2618: Rv2618 - Conserved hypothetical protein, at 2,946,434 to 2,947,111 Rv2618 Rv2619c: Rv2619c - Conserved protein, at 2,947,096 to 2,947,449 Rv2619c Rv2620c: Rv2620c - Probable conserved transmembrane protein, at 2,947,462 to 2,947,887 Rv2620c Rv2621c: Rv2621c - Possible transcriptional regulatory protein, at 2,947,884 to 2,948,558 Rv2621c Position (kb) 2946 2947 2948Strain fitness (log2 ratio) -4 -3 -2 -1 0 1 2at 2945.603 kb on + strand, within Rv2616at 2945.603 kb on + strand, within Rv2616at 2945.603 kb on + strand, within Rv2616at 2945.604 kb on - strand, within Rv2616at 2945.604 kb on - strand, within Rv2616at 2945.813 kb on + strandat 2945.814 kb on - strandat 2946.071 kb on - strand, within Rv2617cat 2946.071 kb on - strand, within Rv2617cat 2946.124 kb on + strand, within Rv2617cat 2946.124 kb on + strand, within Rv2617cat 2946.124 kb on + strand, within Rv2617cat 2946.124 kb on + strand, within Rv2617cat 2946.124 kb on + strand, within Rv2617cat 2946.124 kb on + strand, within Rv2617cat 2946.124 kb on + strand, within Rv2617cat 2946.124 kb on + strand, within Rv2617cat 2946.124 kb on + strand, within Rv2617cat 2946.125 kb on - strand, within Rv2617cat 2946.216 kb on + strand, within Rv2617cat 2946.217 kb on - strand, within Rv2617cat 2946.217 kb on - strand, within Rv2617cat 2946.220 kb on + strand, within Rv2617cat 2946.220 kb on + strand, within Rv2617cat 2946.220 kb on + strand, within Rv2617cat 2946.220 kb on + strand, within Rv2617cat 2946.220 kb on + strand, within Rv2617cat 2946.220 kb on + strand, within Rv2617cat 2946.220 kb on + strand, within Rv2617cat 2946.220 kb on + strand, within Rv2617cat 2946.220 kb on + strand, within Rv2617cat 2946.221 kb on - strand, within Rv2617cat 2946.221 kb on - strand, within Rv2617cat 2946.221 kb on - strand, within Rv2617cat 2946.221 kb on - strand, within Rv2617cat 2946.287 kb on + strandat 2946.288 kb on - strandat 2946.288 kb on - strandat 2946.288 kb on - strandat 2946.288 kb on - strandat 2946.335 kb on - strandat 2946.588 kb on - strand, within Rv2618at 2946.641 kb on + strand, within Rv2618at 2946.641 kb on + strand, within Rv2618at 2946.786 kb on - strand, within Rv2618at 2946.875 kb on + strand, within Rv2618at 2946.875 kb on + strand, within Rv2618at 2946.881 kb on + strand, within Rv2618at 2946.982 kb on + strand, within Rv2618at 2947.074 kb on + strandat 2947.075 kb on - strandat 2947.075 kb on - strandat 2947.075 kb on - strandat 2947.199 kb on + strand, within Rv2619cat 2947.200 kb on - strand, within Rv2619cat 2947.200 kb on - strand, within Rv2619cat 2947.200 kb on - strand, within Rv2619cat 2947.475 kb on - strandat 2947.481 kb on - strandat 2947.513 kb on + strand, within Rv2620cat 2947.513 kb on + strand, within Rv2620cat 2947.514 kb on - strand, within Rv2620cat 2947.529 kb on + strand, within Rv2620cat 2947.529 kb on + strand, within Rv2620cat 2947.529 kb on + strand, within Rv2620cat 2947.529 kb on + strand, within Rv2620cat 2947.529 kb on + strand, within Rv2620cat 2947.530 kb on - strand, within Rv2620cat 2947.530 kb on - strand, within Rv2620cat 2947.530 kb on - strand, within Rv2620cat 2947.530 kb on - strand, within Rv2620cat 2947.573 kb on + strand, within Rv2620cat 2947.573 kb on + strand, within Rv2620cat 2947.574 kb on - strand, within Rv2620cat 2947.574 kb on - strand, within Rv2620cat 2948.007 kb on + strand, within Rv2621cat 2948.007 kb on + strand, within Rv2621c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with copper (II) chloride 0.08 mM
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2,945,603 + Rv2616 0.54 -0.3
2,945,603 + Rv2616 0.54 -4.7
2,945,603 + Rv2616 0.54 -1.2
2,945,604 - Rv2616 0.55 -0.3
2,945,604 - Rv2616 0.55 +0.0
2,945,813 + -0.4
2,945,814 - +0.3
2,946,071 - Rv2617c 0.51 +1.8
2,946,071 - Rv2617c 0.51 +0.8
2,946,124 + Rv2617c 0.63 -0.9
2,946,124 + Rv2617c 0.63 -1.6
2,946,124 + Rv2617c 0.63 +1.8
2,946,124 + Rv2617c 0.63 +0.6
2,946,124 + Rv2617c 0.63 +0.1
2,946,124 + Rv2617c 0.63 +0.4
2,946,124 + Rv2617c 0.63 +0.4
2,946,124 + Rv2617c 0.63 +0.4
2,946,124 + Rv2617c 0.63 -1.8
2,946,125 - Rv2617c 0.63 +0.0
2,946,216 + Rv2617c 0.84 -1.4
2,946,217 - Rv2617c 0.84 +0.2
2,946,217 - Rv2617c 0.84 +1.4
2,946,220 + Rv2617c 0.85 -0.6
2,946,220 + Rv2617c 0.85 -0.6
2,946,220 + Rv2617c 0.85 -1.2
2,946,220 + Rv2617c 0.85 -0.2
2,946,220 + Rv2617c 0.85 +0.6
2,946,220 + Rv2617c 0.85 -1.0
2,946,220 + Rv2617c 0.85 -0.2
2,946,220 + Rv2617c 0.85 +0.5
2,946,220 + Rv2617c 0.85 -0.2
2,946,221 - Rv2617c 0.85 +0.4
2,946,221 - Rv2617c 0.85 -0.2
2,946,221 - Rv2617c 0.85 +0.2
2,946,221 - Rv2617c 0.85 -0.5
2,946,287 + +0.2
2,946,288 - +0.3
2,946,288 - -0.0
2,946,288 - -0.5
2,946,288 - -1.4
2,946,335 - -0.4
2,946,588 - Rv2618 0.23 -0.8
2,946,641 + Rv2618 0.31 -2.2
2,946,641 + Rv2618 0.31 -0.7
2,946,786 - Rv2618 0.52 -0.8
2,946,875 + Rv2618 0.65 -0.9
2,946,875 + Rv2618 0.65 -1.2
2,946,881 + Rv2618 0.66 -2.5
2,946,982 + Rv2618 0.81 +0.1
2,947,074 + -1.5
2,947,075 - +0.6
2,947,075 - -0.1
2,947,075 - +1.1
2,947,199 + Rv2619c 0.29 -0.7
2,947,200 - Rv2619c 0.29 -0.2
2,947,200 - Rv2619c 0.29 +0.4
2,947,200 - Rv2619c 0.29 +0.5
2,947,475 - +0.2
2,947,481 - -0.8
2,947,513 + Rv2620c 0.12 -0.7
2,947,513 + Rv2620c 0.12 +1.5
2,947,514 - Rv2620c 0.12 -2.1
2,947,529 + Rv2620c 0.16 +0.2
2,947,529 + Rv2620c 0.16 +0.9
2,947,529 + Rv2620c 0.16 -0.2
2,947,529 + Rv2620c 0.16 +0.2
2,947,529 + Rv2620c 0.16 -0.7
2,947,530 - Rv2620c 0.16 -1.5
2,947,530 - Rv2620c 0.16 -0.8
2,947,530 - Rv2620c 0.16 +0.6
2,947,530 - Rv2620c 0.16 -0.7
2,947,573 + Rv2620c 0.26 +0.4
2,947,573 + Rv2620c 0.26 -1.1
2,947,574 - Rv2620c 0.26 -0.1
2,947,574 - Rv2620c 0.26 +0.3
2,948,007 + Rv2621c 0.18 -1.4
2,948,007 + Rv2621c 0.18 -0.7

Or see this region's nucleotide sequence