Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1990A

Experiment: 7H9 with copper (II) chloride 0.08 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1989c and Rv1990c overlap by 4 nucleotidesRv1990c and Rv1990A are separated by 243 nucleotidesRv1990A and Rv1991c are separated by 88 nucleotidesRv1991c and Rv1991A overlap by 7 nucleotidesRv1991A and Rv1992c are separated by 99 nucleotides Rv1989c: Rv1989c - Hypothetical protein, at 2,232,739 to 2,233,299 Rv1989c Rv1990c: Rv1990c - Probable transcriptional regulatory protein, at 2,233,296 to 2,233,637 Rv1990c Rv1990A: Rv1990A - Possible dehydrogenase (fragment), at 2,233,881 to 2,234,216 Rv1990A Rv1991c: Rv1991c - Toxin MazF6, at 2,234,305 to 2,234,649 Rv1991c Rv1991A: Rv1991A - Antitoxin MazE6, at 2,234,643 to 2,234,891 Rv1991A Rv1992c: Rv1992c - Probable metal cation transporter P-type ATPase G CtpG, at 2,234,991 to 2,237,306 Rv1992c Position (kb) 2233 2234 2235Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 2232.938 kb on + strand, within Rv1989cat 2232.938 kb on + strand, within Rv1989cat 2232.938 kb on + strand, within Rv1989cat 2232.938 kb on + strand, within Rv1989cat 2232.941 kb on - strand, within Rv1989cat 2233.027 kb on + strand, within Rv1989cat 2233.027 kb on + strand, within Rv1989cat 2233.027 kb on + strand, within Rv1989cat 2233.028 kb on - strand, within Rv1989cat 2233.028 kb on - strand, within Rv1989cat 2233.127 kb on + strand, within Rv1989cat 2233.127 kb on + strand, within Rv1989cat 2233.128 kb on - strand, within Rv1989cat 2233.128 kb on - strand, within Rv1989cat 2233.215 kb on + strand, within Rv1989cat 2233.677 kb on - strandat 2233.680 kb on - strandat 2233.874 kb on + strandat 2233.882 kb on + strandat 2233.962 kb on + strand, within Rv1990Aat 2233.963 kb on - strand, within Rv1990Aat 2234.070 kb on + strand, within Rv1990Aat 2234.070 kb on + strand, within Rv1990Aat 2234.070 kb on + strand, within Rv1990Aat 2234.070 kb on + strand, within Rv1990Aat 2234.071 kb on - strand, within Rv1990Aat 2234.071 kb on - strand, within Rv1990Aat 2234.183 kb on + strandat 2234.235 kb on + strandat 2234.258 kb on - strandat 2234.258 kb on - strandat 2234.318 kb on - strandat 2234.496 kb on + strand, within Rv1991cat 2234.497 kb on - strand, within Rv1991cat 2234.497 kb on - strand, within Rv1991cat 2234.497 kb on - strand, within Rv1991cat 2234.497 kb on - strand, within Rv1991cat 2234.546 kb on + strand, within Rv1991cat 2234.546 kb on + strand, within Rv1991cat 2234.563 kb on + strand, within Rv1991cat 2234.564 kb on - strand, within Rv1991cat 2234.564 kb on - strand, within Rv1991cat 2234.625 kb on - strandat 2234.625 kb on - strandat 2234.640 kb on + strandat 2234.640 kb on + strandat 2234.641 kb on - strandat 2234.641 kb on - strandat 2234.641 kb on - strandat 2234.880 kb on - strandat 2234.880 kb on - strandat 2234.880 kb on - strandat 2234.880 kb on - strandat 2235.161 kb on + strandat 2235.161 kb on + strandat 2235.162 kb on - strandat 2235.162 kb on - strandat 2235.162 kb on - strandat 2235.162 kb on - strandat 2235.162 kb on - strandat 2235.162 kb on - strandat 2235.162 kb on - strandat 2235.162 kb on - strandat 2235.165 kb on + strandat 2235.166 kb on - strandat 2235.166 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with copper (II) chloride 0.08 mM
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2,232,938 + Rv1989c 0.35 -0.1
2,232,938 + Rv1989c 0.35 +1.2
2,232,938 + Rv1989c 0.35 +0.9
2,232,938 + Rv1989c 0.35 +0.5
2,232,941 - Rv1989c 0.36 -1.6
2,233,027 + Rv1989c 0.51 +0.5
2,233,027 + Rv1989c 0.51 -3.1
2,233,027 + Rv1989c 0.51 -1.0
2,233,028 - Rv1989c 0.52 -0.9
2,233,028 - Rv1989c 0.52 -0.2
2,233,127 + Rv1989c 0.69 -1.0
2,233,127 + Rv1989c 0.69 -1.3
2,233,128 - Rv1989c 0.69 +1.8
2,233,128 - Rv1989c 0.69 +0.3
2,233,215 + Rv1989c 0.85 +0.4
2,233,677 - +0.2
2,233,680 - -0.0
2,233,874 + +1.4
2,233,882 + +0.8
2,233,962 + Rv1990A 0.24 -0.1
2,233,963 - Rv1990A 0.24 -0.9
2,234,070 + Rv1990A 0.56 -0.6
2,234,070 + Rv1990A 0.56 -2.4
2,234,070 + Rv1990A 0.56 -0.8
2,234,070 + Rv1990A 0.56 +0.2
2,234,071 - Rv1990A 0.57 -0.2
2,234,071 - Rv1990A 0.57 -1.2
2,234,183 + +2.0
2,234,235 + -1.6
2,234,258 - -0.7
2,234,258 - -0.2
2,234,318 - +1.1
2,234,496 + Rv1991c 0.55 +0.5
2,234,497 - Rv1991c 0.56 +0.1
2,234,497 - Rv1991c 0.56 +0.5
2,234,497 - Rv1991c 0.56 -0.2
2,234,497 - Rv1991c 0.56 -2.1
2,234,546 + Rv1991c 0.70 +1.8
2,234,546 + Rv1991c 0.70 +2.1
2,234,563 + Rv1991c 0.75 -0.5
2,234,564 - Rv1991c 0.75 -1.3
2,234,564 - Rv1991c 0.75 -0.6
2,234,625 - +1.5
2,234,625 - -0.3
2,234,640 + +0.6
2,234,640 + -1.5
2,234,641 - -0.3
2,234,641 - -0.9
2,234,641 - -1.5
2,234,880 - -0.2
2,234,880 - -0.4
2,234,880 - -0.9
2,234,880 - +1.8
2,235,161 + -0.3
2,235,161 + -0.7
2,235,162 - -1.5
2,235,162 - +0.3
2,235,162 - -0.3
2,235,162 - +0.0
2,235,162 - -1.4
2,235,162 - +0.2
2,235,162 - +1.4
2,235,162 - -0.5
2,235,165 + -1.8
2,235,166 - +1.1
2,235,166 - -2.8

Or see this region's nucleotide sequence