Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0078A

Experiment: 7H9 with copper (II) chloride 0.08 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0077c and Rv0078 are separated by 61 nucleotidesRv0078 and Rv0078A are separated by 74 nucleotidesRv0078A and Rv0078B overlap by 4 nucleotidesRv0078B and Rv0079 are separated by 199 nucleotides Rv0077c: Rv0077c - Probable oxidoreductase, at 85,636 to 86,466 Rv0077c Rv0078: Rv0078 - Probable transcriptional regulatory protein, at 86,528 to 87,133 Rv0078 Rv0078A: Rv0078A - Hypothetical protein, at 87,208 to 87,801 Rv0078A Rv0078B: Rv0078B - Conserved protein, at 87,798 to 88,004 Rv0078B Rv0079: Rv0079 - Unknown protein, at 88,204 to 89,025 Rv0079 Position (kb) 87 88Strain fitness (log2 ratio) -2 -1 0 1 2at 86.359 kb on + strand, within Rv0077cat 86.359 kb on + strand, within Rv0077cat 86.360 kb on - strand, within Rv0077cat 86.378 kb on + strand, within Rv0077cat 86.430 kb on - strandat 86.436 kb on + strandat 86.448 kb on + strandat 86.528 kb on - strandat 86.682 kb on - strand, within Rv0078at 86.836 kb on - strand, within Rv0078at 86.925 kb on - strand, within Rv0078at 87.125 kb on - strandat 87.276 kb on + strand, within Rv0078Aat 87.289 kb on - strand, within Rv0078Aat 87.343 kb on + strand, within Rv0078Aat 87.605 kb on + strand, within Rv0078Aat 87.606 kb on - strand, within Rv0078Aat 87.632 kb on - strand, within Rv0078Aat 87.955 kb on + strand, within Rv0078Bat 87.955 kb on + strand, within Rv0078Bat 87.955 kb on + strand, within Rv0078Bat 87.955 kb on + strand, within Rv0078Bat 87.955 kb on + strand, within Rv0078Bat 88.233 kb on - strandat 88.233 kb on - strandat 88.280 kb on + strandat 88.440 kb on - strand, within Rv0079at 88.631 kb on + strand, within Rv0079at 88.681 kb on + strand, within Rv0079at 88.682 kb on - strand, within Rv0079at 88.732 kb on + strand, within Rv0079at 88.779 kb on - strand, within Rv0079at 88.779 kb on - strand, within Rv0079

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with copper (II) chloride 0.08 mM
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86,359 + Rv0077c 0.87 -0.8
86,359 + Rv0077c 0.87 -0.3
86,360 - Rv0077c 0.87 -1.4
86,378 + Rv0077c 0.89 -0.8
86,430 - -1.2
86,436 + +2.4
86,448 + -0.9
86,528 - -1.0
86,682 - Rv0078 0.25 -0.4
86,836 - Rv0078 0.51 -0.9
86,925 - Rv0078 0.66 -2.7
87,125 - -2.0
87,276 + Rv0078A 0.11 +0.3
87,289 - Rv0078A 0.14 +0.5
87,343 + Rv0078A 0.23 -0.2
87,605 + Rv0078A 0.67 -0.4
87,606 - Rv0078A 0.67 +0.4
87,632 - Rv0078A 0.71 +1.2
87,955 + Rv0078B 0.76 -1.2
87,955 + Rv0078B 0.76 +0.4
87,955 + Rv0078B 0.76 +0.8
87,955 + Rv0078B 0.76 +0.7
87,955 + Rv0078B 0.76 +1.5
88,233 - -0.7
88,233 - +0.8
88,280 + +1.8
88,440 - Rv0079 0.29 +0.7
88,631 + Rv0079 0.52 +0.4
88,681 + Rv0079 0.58 +0.1
88,682 - Rv0079 0.58 -0.0
88,732 + Rv0079 0.64 -0.3
88,779 - Rv0079 0.70 -0.7
88,779 - Rv0079 0.70 +1.8

Or see this region's nucleotide sequence